Conserved Protein Domain Family
Tmemb_185A

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pfam10269: Tmemb_185A 
Transmembrane Fragile-X-F protein
This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.
Statistics
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PSSM-Id: 402059
Aligned: 24 rows
Threshold Bit Score: 139.898
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_973857     28 LKLDHTVSSSWWMVFFPLWAFHA---VVARGRF-------SLPApVAPRNRHWAPCHAVVAT----PLLVAFELLLCIYL 93 
Q9U2T2        33 LKLDGKVSFSYAFVFAPLWACNL---LVFVGAIvgicsfcSKPP-SRNEIVMRVDFSAMLITatehIFLCTFVSLVFIKL 108 Caenorhabditis ...
XP_001892744  37 LRFDGTIELNYALVFLPLWICEF---IVFLGAIvaaisfvISPP-SLTESSLRSDFYGMILCtgehGLLILFEVLCCHKL 112
XP_001850518  30 LRLDDYIDWPYWVIFIPLWVWKS---IATLGAIvgaivwcRYPH-YRVEGDSYAHFKAMLISlslhLILLMFELLACDRL 105
XP_030836461  30 LRLDETIQCSFWLVFLPLWFWKG---VVIVGAIvagvvwwKHPE-YRVEGEGYIDMKAIIIClalnSLLLIFEILACDQL 105
2_pfamImport   1 LRLDGIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 76 
Q05AZ1        30 LRLDNIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 105 tropical clawed...
Q4D9L8       117 VRLDYNKGWPWAAVFAPVWVALVpllLIGGLLVfhgvtrrEIAS-----------------------TLLGLMCFLVTFA 173 Trypanosoma cruzi
Q38EE7       117 VRLDYELSWKWPVVFIPLWIALAppiLLALGLLaagikqlDFLC-----------------------VCVGVEILLFVGS 173 Trypanosoma brucei
XP_004358117 121 VKINHRVDWSWAKVFSPFWIIWG---LVVLAMIivaavsrRMRS---------------TVLmsksVAILVFGALIVANL 182
NP_973857     94 ESSYA-RWPPAVSLKIAFLPLLAFELTILVDNLRMCRAL------MPGDDDSIT--------------DDAIWEALPHFW 152
Q9U2T2       109 EFDYLfEPGYPLPWTIVFCPLFSLSILSIGIAIWSLRHD------KPFEFEFFY-------------------------- 156 Caenorhabditis ...
XP_001892744 113 QANATvD---ELPWLLVFVPIFALSLLSVVVAIWAIRND------KSFELELFF-------------------------- 157
XP_001850518 106 TSG-------RHLWVLVFIPLIFGSVASVGACVWAVKHD------RSFELELFC-------------------------- 146
XP_030836461 106 ESSNAaKPW-RHPWLIVFMPLFLTSPVSIAACVWGFKHD------RGLELEAMC-------------------------- 152
2_pfamImport  77 ERG-------SHFWLLVFMPLFFVSPVSVAACVWGFRHD------RSLELEILC-------------------------- 117
Q05AZ1       106 ERGN------HYFWLLVFMPLFFVSPVSVAACVWGFRHD------RSLELEILC-------------------------- 147 tropical clawed...
Q4D9L8       174 VAMFVvGLSGALTWTIALAPSAAIYVFQSCFILRYLLPFq----fRNGFAEFIP--------------PGSSVCLSRMYW 235 Trypanosoma cruzi
Q38EE7       174 IATFVaGLCGALSWPVALSPAIAFYAVRVLHIIPHLFPSrfvqnsEDGSGEVTF--------------SRKKYCL----- 234 Trypanosoma brucei
XP_004358117 183 DHAIH------IDWTVVFIPVYFLLAVNICSIIPNTIYS------R--YLKRLQgekeyfnaatdyglGYAGWLYRRYIF 248
NP_973857    153 VAISMVFTLAATFFTLLKL----------SGDVVALGWWDLFINF------------GIAECFAFLVCTKWSNPVIHRSS 210
Q9U2T2       157 -AINIVQLV----FIAFKL----------DKQVD----WTWAVVFiplwvvlslaavGVLYALVLSVVLIRSRHFIPAH- 216 Caenorhabditis ...
XP_001892744 158 -SINIVQFV----FVAFKL----------DGILD----WHWTIVFiplwvvlslsvvGVLYAFVLAVVLARSVHMLASQ- 217
XP_001850518 147 -AVNALQFV----FLPLKL----------DGFVS----WSWEVVFvplwivlclslvAVLYSIIFCGILLRTPEVSHQQ- 206
XP_030836461 153 -SINILQFI----FIALKL----------DEIIT----WRWGVVFiplwiltclmclIVLYYVIWSLLILRATELMAEQ- 212
2_pfamImport 118 -SVNILQFI----FIALRL----------DKIIH----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 177
Q05AZ1       148 -SVNILQFI----FIALRL----------DRIIT----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 207 tropical clawed...
Q4D9L8       236 GFLLETVFEKLCCFSFISLallraaqtggEDTSKLISFW---IVFtplily-fgcmtLVSAARRFFAGTVEGQSCLLSR- 310 Trypanosoma cruzi
Q38EE7       235 -FVVMVLFEEGCAIAFFTLlmlramqkseESKDEPLSFW---IVFspliac-lglkaLLHLCFCMICSKVEQPNQQASQ- 308 Trypanosoma brucei
XP_004358117 249 EAMEVWFIV----FLVIRL----------DRIVT----WSWWINAipil----------vsmLIRLITIVADSKYLAKHT 300
NP_973857    211 RARe-tGSSSTSIRYLDWNSglvvapeedrhqdrwcglqdigghMLKIPVILFQVVLCMYLE------GTP----ERAKD 279
Q9U2T2       217 --------RRQHVYSAILHT------------------------FFVIPALVCLVLLTGKLD------SMNwpdkGSVSE 258 Caenorhabditis ...
XP_001892744 218 --------RRQHLYSALCHT------------------------LLVIPILVFLLLLTGKLD------AISwsddEPVSQ 259
XP_001850518 207 --------KKSAINSAIGNC------------------------ATVLPILVFQVLLADKLD------NEN-------LD 241
XP_030836461 213 --------RRANFMTAVTAV------------------------SLVAPLLTFEILLVNRLD------GIN--------D 246
2_pfamImport 178 --------RRTHITMALSWM------------------------TIVVPLLTFEILLVHKLD------GHN--------A 211
Q05AZ1       208 --------RRTHITMAVSWM------------------------AIVVPLLTFEILLVHRLD------GHN--------Y 241 tropical clawed...
Q4D9L8       311 --------LCRALAAAMGYA----------------------------SLLFMACMLAAKCEaeqnhkAVSlhpsAAVAL 354 Trypanosoma cruzi
Q38EE7       309 --------KSTSAFLFVVYS----------------------------SMIYVACMIAAKANveinkwTDGfnpsAAVAV 352 Trypanosoma brucei
XP_004358117 301 QGSeseEESSFNTFLICCYI------------------------ILIIPIVIFLGLLVSYLN------GKG--------- 341
NP_973857    280 ISIPVLFSPLFLL 292
Q9U2T2       259 LSYTLAMAPLQVS 271 Caenorhabditis elegans
XP_001892744 260 IAFIIVCAPLDLa 272
XP_001850518 242 WPFIGVAGPLLLS 254
XP_030836461 247 YPVSAVFCPLYIS 259
2_pfamImport 212 FSCIPIFVPLWLS 224
Q05AZ1       242 FAYIPIFVPLWLS 254 tropical clawed frog
Q4D9L8       355 LPLEVTLA--LAV 365 Trypanosoma cruzi
Q38EE7       353 IPIQVIFISLFLA 365 Trypanosoma brucei
XP_004358117 342 FAIASVFIPIFIi 354
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