1V5V


Conserved Protein Domain Family
GCV_T

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pfam01571: GCV_T 
Aminomethyltransferase folate-binding domain
This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
Statistics
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PSSM-Id: 460255
Aligned: 61 rows
Threshold Bit Score: 136.565
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1V5V_A  11 FDWHKEHARKIEE--FAG-WEMPIWYS--SIK----------------------EEHLAVRNAVGIFDVS-HMGEIVFR- 61 
Q1AVQ1  15 spvELLRNSQIGPyaFPG---VPAEFTnwR------------------------DEQRAWRESCVLFDQSyHMTDLYIE- 66  Rubrobacter xylanophi...
Q2JFT9  16 LGLPGAVAGTAEDdaVAAhYGDPL------------------------------REQRAVRGGAAVVDRS-HRDVLRVS- 63  Frankia casuarinae
Q9HM98   5 RAAHEAHGATFRE--VAG-RAVPVEYGrpD------------------------RTHRAVRNAAGVTEHA--FDVVVAT- 54  Halobacterium salinarum
O46504 462 YDRLDAQGARWME--KHG-FERPKYFIppDKDllaleqsktf--ykpdwfeiveSEVKCCKEAVCVIDMS-SFTKFEITs 535 cattle
Q16N68 423 YSVLEQRGAVFGT--KMA-YERALYFDtdYIRggqlptmpagsfykpkffnfmeKEYIACAQHVGIIDIS-SFSKIEIKp 498 yellow fever mosquito
Q160N9 428 HAEYARANAHFGQ--VYG-WERPLYFGkqAEPrmtfgrp--------dwfenvrAEVRAAHEGAAIFDAS-PFGKIEVT- 494 Roseobacter denitrifi...
Q5LKS0 430 HEGLVAAGARFEA--RGG-WERALHFGgdEAHlpltfgip-------kwrdqvaREVDACRNGAAILDQS-AFGKIMVQ- 497 Ruegeria pomeroyi
Q5LQQ2 427 YHVMKAHGAAYGE--VQG-WERPGWFApgGETpvydhsfyr-----pgwfdhaqAEQRAVRGAAGLIDYS-MLGKLMVE- 496 Ruegeria pomeroyi
Q4FLB1 429 HEELKKEGACFG---VSGeYERPMWYAksNEKaeykysfdy-----qnwypsveFETKNTITNVGLFELS-PFSKYEIK- 498 Candidatus Pelagibact...
1V5V_A  62 -G-------KDALKFLQYVTTNDISKPPa---ISGTYTLVLNERGAIKDETLVFNMGNNEYLMicdSDAFEKLYA-WFTy 129
Q1AVQ1  67 -G-------PDVKRLLSDLGINSFEGFKk---NNAKQFVACNHDGYVIGDAILFGLEDDRVSLvgrPTAHN-----WVQ- 129 Rubrobacter xylanophi...
Q2JFT9  64 -G-------PDRLSWLHSITSQHLSALGa---LRGTEALVLSPHGHVEHHLVLADDGTSTWVDvepGTG--GILLrYLE- 129 Frankia casuarinae
Q9HM98  55 -G-------ED----AHEVVAAGVSGGVptedGRGAYVVVCDD-GRVRADGYVFAT-DDRLLAllpAGEGDGVASrWRE- 119 Halobacterium salinarum
O46504 536 tG-------DQALEILQYLFSNDLDVPV----GHIVHTGMLNERGGYENDCSIARLSKRSFFMispTDQQVHCWA-WLK- 602 cattle
Q16N68 499 -GvhndgdkNNVLDYLQKMCANDVDIET----SHIVHTGMLNERGGYENDCMLIRQNVDHFFMispSSQQTRIYE-WMS- 571 yellow fever mosquito
Q160N9 495 -G-------PDACAFLQHLAMRNMDRPT----GTAIYTALLNERGTFESDITAQRIADDHYRLfvgTNAIKRDLA-WAL- 560 Roseobacter denitrifi...
Q5LKS0 498 -G-------PDACTFLNRLCAAQMDIAE----GRIAYTQILNARGGVESDLTVQRHGPETYLMivgAGEVVRDMK-RMRe 564 Ruegeria pomeroyi
Q5LQQ2 497 -G-------RDAEAFLQRACTNDMALPV----GRVAYTLMLNDHGGIESDVTVARHGPDSFMVmsaISHTRRDRD-HLR- 562 Ruegeria pomeroyi
Q4FLB1 499 -G-------ENAHSELQRICTANIKNEI----GRSTYTQMLNEGGGIETDLTVICIDKNHFRIissAATRTHDKA-HIL- 564 Candidatus Pelagibact...
1V5V_A 130 lkrtiEQFTKl-----------dLEIELKTYDIAMFAVQGPKARDLAKDLFGIDi-------nE-MWWFQARWVELDGIK 190
Q1AVQ1 130 -----YHAESgdydvkverderyAANPEKRRRLYRYQIQGPNAAELLEKLNGGPl--------PqVPFFSMYEINIGDRK 196 Rubrobacter xylanophi...
Q2JFT9 130 -----SMRFMl-----------rVEPADLGAVTAVLSVLGPRAAQVAAAALGGPgdgapgpglPePQAPGPVGAPITGPY 193 Frankia casuarinae
Q9HM98 120 -----RAGNRd------------AAVTLSTGEFGTFGVHGPQATEKVASVLHRAsp-----peErLRFVRGEmeg----- 172 Halobacterium salinarum
O46504 603 -----KYMPEds----------nLILEDVTWKYTALNLIGPRTVDVLSELSYAPmt------pDhFPSLFCKEMSVGYAN 661 cattle
Q16N68 572 -----RNLPKda----------sVKLNDVTSMYTVLNVVGPKSTQLMSELSNSN---------VkLQPFTYRKLNIGYAS 627 yellow fever mosquito
Q160N9 561 -----RHRDGf-----------dVTLKDSTEDYAVLCLMGPDAARIIAATGAPEl--------CqLGYFQVGPAFIAGKH 616 Roseobacter denitrifi...
Q5LKS0 565 trgdfR-----------------VEFTDVTSGYAAIGLAGTKAREVLQATTNTPv--------PdLKRFRFAPVEIGLAR 619 Ruegeria pomeroyi
Q5LQQ2 563 -----NLIRPde----------dVRLRDATSAYAVLSLCGPKSRQILADVADIDls------dAaFPFNSLARFHIGHAP 621 Ruegeria pomeroyi
Q4FLB1 565 -----KHLSPn------------LEFKDITDDLVCLGIFGPKSRNLISKISNDDfs------nEtFKFGYGKFVTLGSKK 621 Candidatus Pelagibact...
1V5V_A 191 M--------LLSRSGYTGENGFEVYIedanpyhpdeskrgEPEKALHVWERILEEGKKYGIKPCGLGARDTLRLEAGY-- 260
Q1AVQ1 197 V--------RALRHGMSGQPGAEIFG--------------PWEERDEIKGIIVEAGEEYGLRQVGSRTYATNTLESGWip 254 Rubrobacter xylanophi...
Q2JFT9 194 PvgrtgtgtLVRRMPH----GVDLLV--------------GRADLTGTVERLRAAGAGL----AGLSAFDAMRIASRR-- 249 Frankia casuarinae
Q9HM98 173 ------gvtVVRDDDLAGEEGYLVVC--------------AAEDADDVFETLLVRG--LNAVPFGRETWETLTLEAGT-- 228 Halobacterium salinarum
O46504 662 Gi-------RVMSMTHTGEPGFMLYI--------------PIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFF-- 718 cattle
Q16N68 628 Dv-------MIMTFTHTGMPGYCLYI--------------PSEYALHVYDRLMTVGHDYGVRDVGTLTQRFLRIDKFI-- 684 yellow fever mosquito
Q160N9 617 V--------RAARMSYVGEAGWEITC--------------KAENALPIYTALKSSGA----VPAGLYAQTSMRIEKGF-- 668 Roseobacter denitrifi...
Q5LKS0 620 G--------WAGRLSFTGEEGYELYV--------------PSDMAMAAHEALVAAGATH----AGLFASGSLRIESGF-- 671 Ruegeria pomeroyi
Q5LQQ2 622 V--------FAQRLSYTGDLGWEIFV--------------TPDFAEHVFDVLMASGAPQGLRLVGGEALNALRIEAGF-- 677 Ruegeria pomeroyi
Q4FLB1 622 I--------WAQRLSYVGELGFELYI--------------ENKDAKEIYQLIIEEGKNHNLSHCGSHAMDTMRMESGF-- 677 Candidatus Pelagibact...
1V5V_A 261 -----TLYGNETKElqllstdidEVTPLQANLEFA 290
Q1AVQ1 255 spcpaIYTGEEMKpyrqwlpangyeamaslggsfy 289 Rubrobacter xylanophilus DSM 9941
Q2JFT9 250 -----PRLSRETDH---------RTIPHEVG--WL 268 Frankia casuarinae
Q9HM98 229 -----PLFASELAG---------R---TLATLGLA 246 Halobacterium salinarum
O46504 719 -----AFWGQDLNT---------LTTPLECGGESR 739 cattle
Q16N68 685 -----PFWGDELTS---------MTTPFEAGVFYS 705 yellow fever mosquito
Q160N9 669 -----AAMGHELDS---------DLSPVEAGLHHM 689 Roseobacter denitrificans OCh 114
Q5LKS0 672 -----RAFGHELTP---------GTTPQEAGLGAF 692 Ruegeria pomeroyi
Q5LQQ2 678 -----AHWGHDMAY---------TEAPHQVGLGFV 698 Ruegeria pomeroyi
Q4FLB1 678 -----LHWGHDISP---------EENQYEAGLNFA 698 Candidatus Pelagibacter ubique HTCC1062
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