1SCU


Conserved Protein Domain Family
sucCoAbeta

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TIGR01016: sucCoAbeta 
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succinyl-CoA synthetase, beta subunit
This model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC 6.2.1.5) from the GDP_forming (EC 6.2.1.4) enzyme. The N-terminal half is described by the CoA-ligases model (pfam00549). The C-terminal half is described by the ATP-grasp model (pfam02222). This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G [Energy metabolism, TCA cycle]
Statistics
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PSSM-Id: 273396
Aligned: 10 rows
Threshold Bit Score: 551.215
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SCU_B   1 MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGaGPWVVKCQVHAGGRGKAGGVKVVNsKEDIRAFAENWLGKR 80  Escherichia coli BW2952
O27115   1 MKFYEYSAKEIFRAEGISTPRGGVAETPEEAERIAAELG-CDVAVKSQVLTGGRGKAGGIRFAS-PSGVAEVTGDLLSSE 78  Methanothermobacter t...
Q57663   1 MKLHEYEAKNIFKKYGIPVPESFLVSKEDDLNSINVDK---EVVLKAQVLVGGRGKAGGILFASnKEEFIKKAEELFNKE 77  Methanocaldococcus ja...
O28097   1 MRLHEYQAKQIFSKHGIRVARGELATSVEDVRGIAEELG-GKVVLKSQVLVGGRGKAGGIKKAYsVEEAVEKAKEMFGSV 79  Archaeoglobus fulgidu...
P45101   1 MNLHEYQAKQLFEHYGLPVKNGAVCQSVEDVDLVLAQLSgGKWAAKCQVHAGGRGKAGGVKLVQdVEEARAFAEKWLGQR 80  Haemophilus influenza...
O67546   1 MKLHEHQAKEIFAKYGIPVPEGKVAFSLKEAKEVAEELGeFPLVVKAQIHCGGRGKAGGVKIVKdMDELEKAVESLLGKV 80  Aquifex aeolicus VF5
O05966   1 MNIHEYQAKEILRKYGVPTSTGLVVTKTEKINETIDKLNtKVYVIKAQIHAGGRGKAGGVKVAKsKEEAKKVAHDMFGIN 80  Rickettsia prowazekii...
O84828   1 MHLHEYQAKDLLTAYQLPIPPYHVATSVPEVETAIQAEQwKAGVVKAQVHAGGRGKNGGVVIAHsPEDLLAAADKLLHMQ 80  Chlamydia trachomatis...
Q9Z6T6   1 MHLHEYQAKDLLASYDVPIPPYWVVSSEEEGELLITKSGlDSAVVKVQVHAGGRGKHGGVIVAKsSAGILQAVAKLLGMH 80  Chlamydia pneumoniae
P07460   1 MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGaGPWVVKCQVHAGGRGKAGGVKVVNsKEDIRAFAENWLGKR 80  Escherichia coli
1SCU_B  81 LVtyqTdangQPVNQILVEAATDIAKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQG 160 Escherichia coli BW2952
O27115  79 VR---G----ETVEKVLIEEKIPIDRELYVSAVIDRTAKMPLIMASAEGGVDIEELAARSPEKIVRYHINPLDEFLPYEA 151 Methanothermobacter t...
Q57663  78 VK---G----EKVEKILVEEKLPIEKEYYVSIIIDRDAKKPLIIFSTEGGVDIEEVAEKNPEKIIKYHIDVRKPFLPYIA 150 Methanocaldococcus ja...
O28097  80 LK---G----HIVEKIYVEEMIEVQREMYAGLTIDRANKGIAAILSSVGGMDIEEIAVKHPEKIARIAVNPKWGLWDYQI 152 Archaeoglobus fulgidu...
P45101  81 LVtfqTdklgQPVNQIYFEETCDIDKEFYLSAVVDRTSQKVVFIASSEGGMNIEEVVQNSPHLLHKVTIDPLFGGLPYQG 160 Haemophilus influenza...
O67546  81 LKtfqCpd-gKPVNRVLIEKATNIDKEYYLAITLDRSKSKPVIMASAAGGMEIEEIVKENPEAIIIETIDPELGLMPYQA 159 Aquifex aeolicus VF5
O05966  81 LVthqTgpqgQKVNRIYIESGCDILKEYYFSIVFDRSASCITFIASTEGGVDIEAVAEKMPEKIIKFAVDPATGLQDFHM 160 Rickettsia prowazekii...
O84828  81 FSsnqTaglsLPINKVLISPLVEIASEYYLAIVIDRKHRCPVIMLSKAGGVDIEEVAEKQPDQLLKMTLPSSGKIYGYQL 160 Chlamydia trachomatis...
Q9Z6T6  81 FTsnqTadgfLPVEKVLISPLVAIQREYYVAVIMDRKHRCPVLMLSKAGGMDIEEVAHSSPEQILTLPLTSYGHIYSYQL 160 Chlamydia pneumoniae
P07460  81 LVtyqTdangQPVNQILVEAATDIAKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQG 160 Escherichia coli
1SCU_B 161 RELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQgDLICLDGKLGADGNALFRQPDLREMRDQSQEDp 240 Escherichia coli BW2952
O27115 152 REIARKMGLESELIPSVGGVIWKLYQLFRKYDARLAEINPLVISGD-SVIAADAKLEVDDDSIYRHREFMEMEEYEPEE- 229 Methanothermobacter t...
Q57663 151 RWIVKEAKLPSNEIGKVADVIYKLYKIFKELDATMVEINPLVITKDgNVYAADAVLHLDDDAAFRH-NYEEFEEYKNKEk 229 Methanocaldococcus ja...
O28097 153 RELLLNSQMPREYWKEVASILKTLYRIMVHYEAELVEINPLVVTPD-GLVAADARLNIDDSALFRHRDLEKLRDYTEADq 231 Archaeoglobus fulgidu...
P45101 161 RELAFKLGLSGTQNKQFTDIFMGLSRLFLEKDLSLLEVNPLVLTPQgNLVCLDAKISVDDNALFRHKDLLALQDLTQNDa 240 Haemophilus influenza...
O67546 160 RELAFKLNLP---VKEFASIALKLYQIYSDLDASLVEINPLVLTKEgNLIALDAKLDIDDNALFRHKDLEEMEDETQLPq 236 Aquifex aeolicus VF5
O05966 161 RGIAYELGFKDNQAKQMKEIVKAVYNAFIETDATQIEINPLIINSYgNLLALDAKITFDDNGLFKHPNITAMRDHDEEDp 240 Rickettsia prowazekii...
O84828 161 RRIAKFMEWDQPIADQGNRIIRQLLQCFYEKDASLLEINPLVLTKDgSLVILDAKMTIDDNALYRHPQLADCYDPSQENi 240 Chlamydia trachomatis...
Q9Z6T6 161 RQATKFMEWEGEVMHQGVQLIKKLAKCFYENDVSLLEINPLVLTLEgELLVLDSKITIDDNALYRHPNLEVLYDPSQENv 240 Chlamydia pneumoniae
P07460 161 RELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQgDLICLDGKLGADGNALFRQPDLREMRDQSQEDp 240 Escherichia coli
1SCU_B 241 reaqaaqweLNYVALDGNIGCMVNGAGLAMGTMDIVKlHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFG 320 Escherichia coli BW2952
O27115 230 ---------FAFVKLDGDIAVIGNGAGLTLTAMDLIK-LNGEPATFLDIGGGASEDVIRRALDLVISHPSVRVVFLNVLG 299 Methanothermobacter t...
Q57663 230 l-------pFAYVELDGDVAVIGNGAGLTLASMDIINnLGRKPACFLDIGGGADAETVKLALRKVLENKNVKGIFINILG 302 Methanocaldococcus ja...
O28097 232 meriamekgLNYVKLDGNVGVLANGAGMAMATMDLIYiYGGKPANFLDIGGGASAEVVREAINLILSDKNVKVVFINIFG 311 Archaeoglobus fulgidu...
P45101 241 reaeaekfqLNYVALEGDIGCMVNGAGLAMGTMDIVKlYGGKPANFLDVGGGATQERVAEAFKIILTDPSVKVILVNIFG 320 Haemophilus influenza...
O67546 237 leveakkygLNYIKLNGNIGCMVNGAGLAMATMDIIKlAGGEPANFLDVGGGANVEQIANAFRILMADPDVKAVFINIFG 316 Aquifex aeolicus VF5
O05966 241 letraanagLSYVKMDGNIGCMVNGAGLAMATMDIIKlYGALPANFLDVGGGADRERVKEALKIILSDKEVKGILVNIFG 320 Rickettsia prowazekii...
O84828 241 rdvlakqlgLSYIALDGTIGCLVNGAGLAMSTLDILKlYGGSAANFLDVGGSASEKQIQEAISLVLSDKSVRVLFIHIFG 320 Chlamydia trachomatis...
Q9Z6T6 241 rdvlakqigLSYIALSGNIGCIVNGAGLAMSTLDILKlHGGNAANFLDVGGGASQKQIQEAVSLVLSDESVKVLFINIFG 320 Chlamydia pneumoniae
P07460 241 reaqaaqweLNYVALDGNIGCMVNGAGLAMGTMDIVKlHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFG 320 Escherichia coli
1SCU_B 321 GIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGl---nIIAAKGLTDAAQQVVAAVE 386 Escherichia coli BW2952
O27115 300 GITRADDVARGVVNALRDARRDVPLVIRLTGTNEEEGQRILREAG-----IPFETSLERAAEKAVEIAK 363 Methanothermobacter thermautotro...
Q57663 303 GITRCDEVAKGIVEVLKEHP-NVKFAVRMMGTNEEIGRKILEEHG-----IPYETSMEEAGRKLIEQL- 364 Methanocaldococcus jannaschii DS...
O28097 312 GITRCDEVAKGLKEALADVS--TPVVVRLAGTNEEEGRKIMDEFAkdrpnFHIVETMEEGAEKAVKLAE 378 Archaeoglobus fulgidus DSM 4304
P45101 321 GIVRCDLIAEGVIAAVNEVGVRVPVVVRLEGTNAEMGRQILAESDv---nILTAQSLQQAAELAVNAAK 386 Haemophilus influenzae Rd KW20
O67546 317 GILRVDRLAQGLIEASKMVELRVPIVARLEGTNVEEGKRMLQESGl---nFIIAEDMWDGAKKAVEIAN 382 Aquifex aeolicus VF5
O05966 321 GIMRCDIIAEGIIAAAKDIGIKVPLVVRLAGTNVEKGKEILSNSDl---kIIPAHDLADAANKIVEAIR 386 Rickettsia prowazekii str. Madrid E
O84828 321 GIMDCAVVASGLVSAMQGQKETIPTVIRLEGTNVDKGKDMIINAGi---pCEFVTSMSEGAELAVQLSR 386 Chlamydia trachomatis D/UW-3/CX
Q9Z6T6 321 GIMDCSVVASGLVAVMETRDQVVPTVIRLEGTNVELGKEIVQQSGi---pCQFVSSMEEGARRAVELSM 386 Chlamydia pneumoniae
P07460 321 GIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGl---nIIAAKGLTDAAQQVVAAVE 386 Escherichia coli
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