Conserved Protein Domain Family
YhfZ_full

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NF041241: YhfZ_full 
GntR family transcriptional regulator YhfZ
Full-length homologs of the transcriptional regulator YhfZ from Escherichia coli, with an N-terminal GntR-like domain, are quite divergent. See PF14503 (YhfZ_C) for the broader family. This HMM identifies a subset in which the motif MPLPYxxxYEGLA and the C-terminal PxY motifs are both well conserved, suggesting orthology with conserved function.
Statistics
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PSSM-Id: 469143
Aligned: 39 rows
Threshold Bit Score: 403.069
Created: 11-Oct-2024
Updated: 3-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_019355996      6 DRFLTRNGLAARQLALLLLEYEPERRLPRVRDFAEELGCGNGTVQGALRLLEEAGAIETAARGHLGTFLVRSDRSVLWRL 85  Streptomyces...
1_ncbifamImport   1 RTFIKKEGVVITTLARYLLGEKCGNRLKTIDELATECRSSVGLTQAALKTLESSGAIRIERRGRNGSYLVEMDNKALLSH 80 
WP_008457822      3 RSFIKKEGVAQSSLARYLLGEKCGNRLKTIDELASECGFSVGLTQAALKTLEKAGAVSVERRGRNGSYLLSMDNKALLAF 82  Enterobacter...
WP_015834719      3 RELLKKEGVARACLARYLLGECCGNRLKTIDELASDYALSVGLVQFALKKLESSGAVCLDRRGRNGSYLVSMNHKALLVH 82  Photorhabdus...
WP_008911602      3 QAFIKKEGIAQSYLSRYLLVLEKGCRLKTIGELAKDCDLSVGLMQSALKSLEALGAINIERRGRNGSFIAMIDHKLLIKF 82  Providencia ...
WP_017893944      3 KAFIKKEGLALVSLARYLFGLAPGARLKTIDELSSELNLSVGVVQHALKTLETASCVTLERRGRNGTLLSNMNYPALLEQ 82  Serratia
WP_019081838      3 KKFIKKEGLALVSMARYLIGERAGNRLKTIDELSDDFGISVGVVQHALKVLEADGAIIVERRGRNGTLLIDLNMPLLLQQ 82  Yersinia
WP_009385603      3 VQYISKEGAAIMNIAQYLMTTAEGDRLRTIDSLSDDYSVSVGFIQKALTTIEQRGAVVLSKQGRNGTFISQLNYRELVSC 82  Vibrio
WP_011219421      3 TKYIKKEGAAVINIARYLMSQKEGARLRTIDSLAEEFELSVGLVQKALKKIEADGVIALSRQGRNGTYISRLDSEEIVRL 82  Photobacteri...
WP_006071578      4 QNYIKKNGAAIIHIARYLLTTEAGDRLKTIDELSIDIGCSVGYVANAIKFIEKEEAVYLSRQGRNGTIISSLNFNKLVGI 83  Vibrio
WP_019355996     86 SGLGTLLAAMPLPYSRRYEGLATGLRAAFDdaGTPFGITFMRGAGSRATALLEGKADLVVLSRYAADRLIEEYPedLSLV 165 Streptomyces...
1_ncbifamImport  81 VDINNVVCAMPLPYTRLYEGLASGLKAQFD--GIPFYYAHMRGADIRVECLLNGVYDMAVVSRLAAESYLSQNN--LCIA 156
WP_008457822     83 ADIGNVVCAMPLPYTRLYEGLASGLKAQFD--GIPFYYAHMRGSDVRVECLLNGVYDLAVVSRLAADSYLSNPD--LFIA 158 Enterobacter...
WP_015834719     83 ADIGNVVCAMPLPYTRLYEGLASGLKAQFE--GIPFYFAHMRGSDARVECLRNGIYDMAVVSSLAAQTYLEQRD--VLAV 158 Photorhabdus...
WP_008911602     83 ANIGNIVCAMPLPYARVYEGLASGLKTQFL--DIPFYFAHMRGSDIRIECLENGVYDLAVTSRLAAEQHLIEHN--VHIA 158 Providencia ...
WP_017893944     83 ADIGNIVCAMPLPYTRLYEGLASALKAQFE--GYPLYYAHMRGADVRIECLIDGVYDMAVVSHLAAESYLRDGK--VTAA 158 Serratia
WP_019081838     83 ADLGNMVCAMPLPYTKLYEGLASGLREQFT--LLPLYFAHMRGAEVRIECLIDGIYDMAVVSHLAAKSYLDQGK--VALA 158 Yersinia
WP_009385603     83 AGINNVVCAMPLPYTRHYEGLASGLKAQLG--GLPLYFAHMRGASVRAECLKNGTYDVAIMSKLAAKELASG----LVTA 156 Vibrio
WP_011219421     83 AGLGHVVCAMPLPYTKHYEGLASGLKAQMS--SLPLYFAHMRGASVRAKLLSSGVHDIAIMSKLAAQSYSDG----LTVA 156 Photobacteri...
WP_006071578     84 SEIGNIVCAMPLPYTKHYEGLASGLKQQID--NVPLYFAHMRGAGVRAECLSDGIYDIAIMSKLASEKYVAEGD--LEIA 159 Vibrio
WP_019355996    166 VDLGPTTYVGAHGVLLREGGSLEAPglRVAVDHASEDQRLLAERAFAGRaDVEWIECSYMQLLDLLVQDKADATVWNLDE 245 Streptomyces...
1_ncbifamImport 157 LELGPHTYVGEHQLICRKGESGNVK--RVGLDSRSADQKIMTDVFFGDS-DVERVDLSYHESLQRIVKGDVDAVIWNVVA 233
WP_008457822    159 LALGPHTYVGEHKLICRAGQQESIR--RIGIDPRSADQRIMTDVYFSGQ-DVELLDVSYHECLHRIAKGSVDAVIWNVSN 235 Enterobacter...
WP_015834719    159 LELGPCTYVGGHQLVYRKGEEHNIR--RVGLDNRSADQKIMTEVYFAGQ-DITLVDISYHECLYKVAKGDIDAVIWNVSK 235 Photorhabdus...
WP_008911602    159 LALGKYSYAEGHKLIYRQGALNDIR--RVGVDSTSTDQKIITEQWSTGG-NYDFVDVSYHECLNKIVSGEIDAAIWNVGQ 235 Providencia ...
WP_017893944    159 MMLGAGSYVDGHQLVYRKGEKQNIR--RIGLDSRSPDQRLLTEVVFAGQ-DIERINLPYNESLTRIERGEIDATVWNVTE 235 Serratia
WP_019081838    159 LNLGNGSYVDGHQLICRRGEQNNIR--RVGLDPRSPDQCLLTEIKFAGQ-PIELVELPYSDCIAHINRGDIDAAIWNLAD 235 Yersinia
WP_009385603    157 IDLGAHTYSHEHRLIYRQGQYDQIL--RVGVDPDSPDQKILTSQAFADK-SIEIVEIHYGESLTHLLNGDIDAVVWLPEA 233 Vibrio
WP_011219421    157 VNLGKNSYSNDHRVIYRKGEYSAIR--RVGVDSDSPDQQILTKQAFPDQ-DIDIVEINYDDSLVHLASRNIDAVIWLTEA 233 Photobacteri...
WP_006071578    160 VELDAHSYVPEHRLIYRQSERNNIK--RIGVDAESPDQKLLTEIYFKDQ-EIEVVPVPYNECLKQIVKGEIDAAIWYASR 236 Vibrio
WP_019355996    246 VQGRLGeGIEVLPLGDEITqd--lSLRNSSAAVIGRAESVAALHAIREAIDTERVTKLQSAVVRGDRMPSY 314 Streptomyces sp. AA1529
1_ncbifamImport 234 ENELTMlGLEATPLTDDPR-----FLQATEAVVLTRVDDYPMQQLLRAVVDKHALLAHQQRVVSGEQEPSY 299
WP_008457822    236 EADLTAlGLTALPLSGDKC-----FLTASEAVVLTRSEDIPIQQLLRTVVDKNALLAHQQSVLSGEQEPSY 301 Enterobacteriaceae
WP_015834719    236 EMELSFrELIAVPLRGNVC-----FMQASEAVILTRVNDIPIQQLLRTTVDKTALLVHQQRVLSGQQDPSY 301 Photorhabdus asymbiotica
WP_008911602    236 GKELEQlGLTTQSLVDDKNlnhdyFYKASEAVILTRKDDIQLQQLITTMIDPNALLAHQKHVIDGVIEPVY 306 Providencia burhodogr...
WP_017893944    236 DLDSLN--LVKEPLNHYPV-----SIKASEAVLLVRNDDRVIPHLVKTLVNLQQLLAHQQEVKKGTREPSY 299 Serratia
WP_019081838    236 NVPHED--LQAIKLQGDER-----YIQASQAVILIRPDNHPIKLLLEKGINETLLLNHQRAVQNGEIEPRY 299 Yersinia
WP_009385603    234 IEMEKY-GLAEQSLSHLPA-----CMDASEAVMLVNGNAEHITLLLRKLLQLTPLLQHQQAVVNGQLTPSY 298 Vibrio
WP_011219421    234 IDMGNV-GLAEKSLNHIPQ-----CEMASEAVLLVRNEAPHIKVLLRNLINKDALISHQKKVVTGEITPSY 298 Photobacterium profundum
WP_006071578    237 EDSIEAmGLSEEPLTSIPD-----FEKASIAVLMVRKGSDYLKAMLKKFVNNEKLLAHQTDVISGKVIPTY 302 Vibrio
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