WP_005610676 4 EGVFLGKRYEILGRIGSGGMADVYKGKDHKLNRFVAIKVLKSDYRSDETFIKKFLSEAQAAAGLMHPNVVNVYDVGQ--- 80 [Ruminococcus] ... WP_012290556 2 IGKILGDRYEIIEEVGVGGMAKVYKALDTVLNRYVAVKVLKNEYMEDQDFLRKFAMEAQSAASLTHANIVSVFDVGSsyv 81 Finegoldia magna WP_013297997 2 IGRMLGNRYEILEKIGEGGMAKVYKAKCHLLNRIVAIKILRSEFVADEEFVRRFKRESQAAASLSHPNIVSIYDVGQ--- 78 Thermoanaerobac... WP_003458522 2 IGKILGNRYELLQCVGEGGMSFVYKARCRKLNRFVAVKILKDEFKNNEEIVRRFKKEATAIANLSNPNVVNVLDVGT--- 78 Clostridium per... WP_002579584 2 NGIVLGNRYELLEKIGEGGMSEVFKARCNKLNRFVAVKILKKEFCNNPEIVEKFKGEATAIATLSDNNIVNILDVGT--- 78 Clostridium but... WP_012422724 2 NGVILGNRYELLQKIGEGGMSEVFKARCNKLNRFVAVKILKKEFCDNEEIVEKFKGEATAIAKLNDSNIVNILDVGT--- 78 Clostridium bot... WP_004441481 2 IGTKLGNRYELLEKVGEGGMATVYKAKCHYLNRFVAIKILKEQFCSDKEFVEKFKREATSVASLSDNNIVNIYDVGS--- 78 Clostridium bot... WP_007064506 2 IGTMLGNRYELLEKIGEGGMALVYKAKCHLLNRYVAVKILKEQYSDDKEFVEKFKREATAVASLSDNNIVNIYDVGT--- 78 Clostridium car... WP_012101764 2 IGTVLGNRYELLKKIGEGGMAVVYKAKDNLLNRNVAVKILKEQFSTDVEFVEKFKREATAAASLSDNNIVNIYDVGS--- 78 Clostridium klu... WP_013237927 2 IGTMLGNRYELLEKIGEGGMAIVYRAKDHLLSRNVAVKILKEEFSSDGEFVEKFKREAAAAASLSDNNIVNIYDVGT--- 78 Clostridium
WP_005610676 81 DR-GLYYMVMELVEGITLKDYIEKK-GKLSAKETISIAIQMVTGIQAAHNCHIIHRDIKPQNIIISKEGKVKVTDFGIAR 158 [Ruminococcus] ... WP_012290556 82 DGrKYNYIVMEYVDGKTLKDIIDEK-QVLPIEDIVNYGVQIASALECAHKNGIIHRDIKPHNMLIDKSNNLKATDFGIAR 160 Finegoldia magna WP_013297997 79 EG-DIYYIVMEYVNGKTLKQLIREAnGPLPIPKALDITRQVCGALEHAHKNHIVHRDIKPQNILVTDDNIVKVTDFGIAR 157 Thermoanaerobac... WP_003458522 79 QD-DINYIVMEYVEGKTLKDIIKEK-GALPYEVAISIGIKVAKALECAHKSGIIHRDVKPQNILVTEEGVVKVTDFGIAK 156 Clostridium per... WP_002579584 79 QD-DINYIVMEYVKGKTLKDVIKQV-GKMNYETGISVAIQIARALDCAHRNKIIHRDVKPQNILVTEDGVMKVTDFGIAK 156 Clostridium but... WP_012422724 79 QE-DINYIVMELVDGKTLKEIIQKT-GKMNYESAIVAAIQVAKALDCAHRNKIIHRDVKPQNILVADNGVIKVTDFGIAK 156 Clostridium bot... WP_004441481 79 EN-NIHYIVMEYVDGKTLKELIVEK-GKIDPKETVRISKQIASALVCAHRNNIIHRDIKPHNILVTKEGIVKVTDFGIAK 156 Clostridium bot... WP_007064506 79 QG-DINYIVMEYVNGKTLKQIIREQ-GKIPTAKTANLAIQIARALDCAHRNNIIHRDIKPQNILVTNEGVVKVTDFGIAK 156 Clostridium car... WP_012101764 79 QG-DINYIVMECVTGRTLKQIIREE-GKIPQDRAVEIAIQITKALKCAHKNNIIHRDIKPHNILVTEDGIVKVTDFGIAK 156 Clostridium klu... WP_013237927 79 QK-DINYIVMECVIGKTLKQVIKEE-KKIPPARAVEVAIQIAKALKCAHKNNIIHRDIKPHNILVTEDGIVKVTDFGIAK 156 Clostridium
WP_005610676 159 ATtSTQTI---STSVMGSVHYTSPEQARGGIVDEKSDLYSAGITMYEMITGHVPFDGDSTVTVALKHLQEEIKSPAEEVP 235 [Ruminococcus] ... WP_012290556 161 IS-SSATLt-yTSTVLGTVHYISPEQAKGKFIDEKSDIYSLGVVLYQMATGEVPFDAPNAVGIALKHIQDPLVPPINLRH 238 Finegoldia magna WP_013297997 158 AA-NGSTItygGGDVLGTAYYFSPEQAKGAMIDEKTDIYSLGIVMYEMLTGKVPFEGESPISVALKHIQENIVPPSKINP 236 Thermoanaerobac... WP_003458522 157 SM-DSSTIa-hTNSVMGSAHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTGVVPFNGDSPVTVAVKHIQEKAIPPKNINQ 234 Clostridium per... WP_002579584 157 SS-TSSTIt-nTSTIMGSAHYLSPEQAKGSFIDCRTDLYSLGVVLYEMVTGNVPFQADSAVTIALKHIQEEVVAPKKLNS 234 Clostridium but... WP_012422724 157 ST-TSSTIt-nTSTIMGSAHYLSPEQAKGGFIDYRTDLYSLGVVIYEMVTGTLPFEADTAVTIALKHLQEQVVPPKNINA 234 Clostridium bot... WP_004441481 157 AS-NSATIt-nSSKVMGSAHYFSPEQAKGSFVDSRTDIYSLGIVMYEMLVGKVPFDGESPVSVAVKHIQNEVVAPKEIDD 234 Clostridium bot... WP_007064506 157 AS-NSVTIt-nSSKVMGSAHYFSPEQARGSFVDCRTDIYSLGIVIYEMCTGRVPYDADSPVSVALKHIQEPVIPPKQLNE 234 Clostridium car... WP_012101764 157 AS-NSVTIt-nSNKIMGSAHYFSPEQAKGGFLDFRTDIYSLGIVMYEMVTGRVPYDAESPVSIALKHIQEPVVPPNQLNE 234 Clostridium klu... WP_013237927 157 AS-DSVTIt-nSNKIMGSAHYFSPEQAKGSFVDFRTDIYSLGIVMYEMVTGRVPYDAESPVSIALKHIQEPVVPPNQLNE 234 Clostridium
WP_005610676 236 DIPYSLECIIMKCTQKNPAMRYQSCDELLQDLKHSLVDP---EGDFvvlGGRRRSDRTVVMSPEEVERLQRERGYDEdde 312 [Ruminococcus] ... WP_012290556 239 DLPQGLNDIIVKAMAKDPNDRFKSATELK-EMLKNYQNY---SSDL-----YQKTTKNPIIKENDEQPEVKEAIYKTpi- 308 Finegoldia magna WP_013297997 237 KVPYKLDKIVLKATEKDINYRYKSASDLLNDIEAYINNP---DKLVv--TNGYDNNVTRVMKSEEINEKLSGTKTLK--- 308 Thermoanaerobac... WP_003458522 235 NIPNSLNDLIMKAMEKDPVNRYQTAKEIIGDLEKIKKDPnvtISSK---SAEDEDQFTRVMSPVVVPNTETNNSEPDedd 311 Clostridium per... WP_002579584 235 KIPDSLNKLILKAMEKEPSKRYQSAKEMIADLQKIKENP---NARId--DDDDDHEHTIIMSAVTEEMAKQNVEVKKnse 309 Clostridium but... WP_012422724 235 KIPDSLNKLILKCMEKEPNKRYQTAQEVIKDLEKIKENP---NAVI---DKVCDDQHTIIMSAVTEEIAKQSAIKTVsts 308 Clostridium bot... WP_004441481 235 KIPESLNSLVLKCLEKNPVKRYQTIKNLEEDLARIENNEnilNGSS----NISENDVTRVMDTAVINDKIKEMAQNDeye 310 Clostridium bot... WP_007064506 235 NIPDNLNKLILKAVEKEPIKRYQTIKDMLTDLRKIENNQevdISTS-----DFDEDMTRIMDAVVVDDKDKYNRNKYeds 309 Clostridium car... WP_012101764 235 NIHESLNKLILKAVEKEPIRRYQTMEDMLLDLQKIENNQ---KLSLl--NDDFNKDMTRIMDPVDIDDDYKNEDDYYnd- 308 Clostridium klu... WP_013237927 235 NIPDSLNRLILKAVEKEPIRRYQTMEDMLVDLKKIENNQkinLSDD-----DLSGDMTRIMDPVDVNNAYKNEDDYD--- 306 Clostridium
WP_005610676 313 ydedyddeddeyDDDYDDEddeydddyddeddedERDRRSSGRGKKKDVnpdtkkIMRILMIVAGVVIALLILFLVgnav 392 [Ruminococcus] ... WP_012290556 309 --------------------------------qsSTKDNKNKSKKILWIi-----LPIILAFLVFVAVLLGKK------- 344 Finegoldia magna WP_013297997 309 -------------------------------------KKKKSGKIFRNI------GIALLILALMASLSYGTMFFLn--- 342 Thermoanaerobac... WP_003458522 312 edddeyyeddedEDEEENNiq-----------tkPQKAINKKKKKSPIL------IIIATILVVALGITLGFLGMKk--- 371 Clostridium per... WP_002579584 310 svheeydddyydDDDYYDDdd------------dEKPKRKGNSNLIKKI------LIGVAGLLMLGLLGWGAYSIL---- 367 Clostridium but... WP_012422724 309 dn-----dyddyDDDYDDYdde---------defKEKKFNGKKTKKILL------GVGGGIFLILLCVGIFTLV------ 362 Clostridium bot... WP_004441481 311 dd-----deeyeEDEYEDEedei--------edkKKRSNKGKTNKKLIL------GIAMAVLFLVVGSVSAYLAF----- 366 Clostridium bot... WP_007064506 310 kydnkyandkkyNDDYDEQy-------------nKKKTMLDPKKRKILM------FVTAAILVLVIGGISGYF------- 363 Clostridium car... WP_012101764 309 -----------eEGSid---------------rfKNKIALDPKKKKIIL------MIALFMLVIVIGGVSGYFYNK---- 352 Clostridium klu... WP_013237927 307 ---------------DEVEpa-----------rkPVKLNLDPKKKKRIL------TTAIGVLVVVIGIISGYIWYN---- 350 Clostridium
WP_005610676 393 gIFKGSGNatvtqsekVKVPDVRGMTVEEATKELKKYDLGIDVVDKKPSNEYKKNQIMSQSPGKGEKVKRHSTVEVVLST 472 [Ruminococcus] ... WP_012290556 345 -YINKNKQd------lVIVPALTGLTENDALNKAKASNLIAVVSEYKTENSVEPGKVIEQTPESSSEVKKGTIIKLVVSK 417 Finegoldia magna WP_013297997 343 -NMAITNE--------VTVPNIKGQTLDKATSILEKNNLKLNITDSQYSDA-PTNTILSQNPPAGETVKKGSTVNVVVSK 412 Thermoanaerobac... WP_003458522 372 -FMEGGKD--------VKIPNVVGEKVEDAKSKLEGLGLKVLEVTEESDQ--EKGIVLKVDPNVDSTVKTGSEVKLTVSG 440 Clostridium per... WP_002579584 368 -GNAGGGKe-------IEVPNLVGMDVDTAKSTLEKLNLVLVEAGEETSDQYPEGTVMEMNPKAGDKVKEKGEVRVIVSG 439 Clostridium but... WP_012422724 363 -SSGVGKE--------VELPNIIGMTLDEAKSKLEGMELTLVDAGSEKSDE-PEGTIIKSDPKAGSSVKAKSKIRVIVSS 432 Clostridium bot... WP_004441481 367 -NKSGGKK--------VEVPNVVGFTKEEAEKVLSEKKLKLV-VAQKVKSDKKEGTILESYPKSGEKVAENSEVRVSISS 436 Clostridium bot... WP_007064506 364 -ALNKASAk-------TTVPKIVGMKQEEAKKAVEDSKLKFVSIGKEKSDK-PEGTVLRTYPEPGTSVSVNSEVRVSISG 434 Clostridium car... WP_012101764 353 -ISSSSSE--------VTVPNIVGMKQDEAKKIVQSKKLTFV-VSATEKSDKAQGTVISCFPKSGTKVKANSEVRVVISE 422 Clostridium klu... WP_013237927 351 -KVYSSGD--------ITVPSIVGMKQDDAKQLVESKKLNFV-IGGKEKSDKPEGTVIDCFPKSGTKVKSNSDVRVIISS 420 Clostridium
WP_005610676 473 GEeaKSTKVPSVIGQDESDAEAAIKAANLVVVKGDPQYSDSveEGKVISVEPDEGTEVDEGSEVTIVVSLG--SQP--AT 548 [Ruminococcus] ... WP_012290556 418 GE--EQVSVPNLSNMTIENAKIQLNKLGLEIGEITKENSDNfeVGKIMKQHPEAGTSIGKDSKIDLVISLGkkEEL--VE 493 Finegoldia magna WP_013297997 413 GK--QTSVVPNVIGSEYRDAQLKIKNSGLNANLI-WDYNDSypNGYVYDQNPRQGVQVENNTVVDIYVSKG--PEM--VT 485 Thermoanaerobac... WP_003458522 441 GE--GQIKVPNLADMSSDEVRRTLKSLGLELVE-DEKYSDKvpSGKVISQSPNANELVDKGSKVKVVFSKGkeIKK--VS 515 Clostridium per... WP_002579584 440 GE--NKLKMPDIREYDLDKAGEILSSYGLKITNKTEEYSDSvaSGEIISQTPTKDTEITKDQEISVVVSKG--PKI--KY 513 Clostridium but... WP_012422724 433 GQ--TKVKMPDLREEDTDTANKILQSLNLKIDNVTEEYSDDvpKGQIISQNPSKNTEIDTTTKISVVVSKGaqVRL--ST 508 Clostridium bot... WP_004441481 437 G---KVAVVPNLKGMELDSAKKTIQDRKLKLGNVKYEFNDNvaAGKIISQTPDVDAEVEEGAEISLVVSNG--PEI--KY 509 Clostridium bot... WP_007064506 435 GP--DKLAVPSLIGMDLDSAKDVIEKSGLKLGNVTREYSDSvpKGSVIKQDPQPDSDATADTKINLVVSRGqeVKD--LT 510 Clostridium car... WP_012101764 423 GP--ATLVVPSVIGLDIDTAKDLITSSGLSVGSVSSKYSNTvaWNQVISQDPEPDSKVENNTKVNIVISKG--PQVkyVT 498 Clostridium klu... WP_013237927 421 GS--DSLTVPNLVGVDFATAKDIISNSGLTLGNVSYRHSDDvaEGDVISQDPTADSKAQNGTKVNLVVSKG--ADAkyVT 496 Clostridium
WP_005610676 549 --VPSIEGKSQSEAESALAAAGLQGS---ASeEYSDS--VAAGIVIS-QGTASGKQVSKGATVSYVVS 608 [Ruminococcus] lactaris WP_012290556 494 --MVDLMGSDISQAINKLKSIGLNIGn-iEK--KYSNs-YDTNQVIWqQY-DAGKKLKKDSSIDVIIS 554 Finegoldia magna WP_013297997 486 --VPNLVNMSLDDATKALKNVGLKVGn-iTT---QPSdsLPDNYVID-QSIPQGTSIQKGKSIDLIVS 546 Thermoanaerobacterium therm... WP_003458522 516 --VPSLVNMNIDSVKNNLNDIGLKLGe--VKyEYSDS--VQQGQVIS-QSPNANEPVDEGSKVSITIS 576 Clostridium perfringens WP_002579584 514 atVPNVVGLSEEKAKSRLANNGLNVS---VTtEEVSDk-SKDGIVSS-QT-SEGDTVKQGSTITITVG 575 Clostridium butyricum WP_012422724 509 --VPNVIGLSLDDAKDRLDNAKLKIS---IVeKETNDe-SKNGIVLS-QS-IEGSKVQQWTTVNITIG 568 Clostridium botulinum WP_004441481 510 stVPNLIGKSIDGAQNALANAGLSMGg--SKaIITEDq-SLDGQVAS-QSIGAGQSIKQGSSVSISYY 573 Clostridium botulinum WP_007064506 511 --VPDVNGKGIDEASGTISSAGFKVT---KSaVDTSDk-SQDGKVIS-QSISGGEQAKAGSTVNLTYY 571 Clostridium carboxidivorans WP_012101764 499 --VPSVYGKSIEDAASIMANAGLKVArnpVD---TSDk-SQDGIVTS-QSVGASQQVKEGTTVTLNYY 559 Clostridium kluyveri WP_013237927 497 --VPDVSGKNIEEAASIMAGSGLKVSrnpVA---TSDk-SQSGVVTS-QSIGGSQQVKEGTTVSLTYY 557 Clostridium
Jiyao W et al.(2023). "The conserved domain database in 2023.",