1T2S,1SI2,1SI3,1U04,1Z26


Conserved Protein Domain Family
PAZ
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cd02825: PAZ 
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PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a nucleic-acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes. This parent model also contains structures of an archaeal PAZ domain.
Links
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Statistics
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PSSM-Id: 239207
Aligned: 9 rows
Threshold Bit Score: 82.8934
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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nucleic
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleic acid-binding interface [nucleic acid binding site]
Evidence:
  • Structure:1T2S; Drosophila Argonaute2 PAZ domain bound to 3' end of ssDNA; contacts at 3.5A
  • Structure:1SI2: PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang
  • Structure:1SI3: PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                      #               
1T2S_A       4 AMPMIEYLErfslkakinn--ttnldysrrFLEPFLR--GINVVYTPpqsf-------qsaPRVYRVNglsrapasse-- 70   fruit fly
1SI2_A       5 AQPVIEFMCevldirnideqpkpltdsqrvRFTKEIK--GLKVEVTHcg----------qmKRKYRVCnvtrrpashqtf 72   human
1SI3_A       5 AQPVIEFXCevldirnideqpkpltdsqrvRFTKEIK--GLKVEVTHcg----------qxKRKYRVCnvtrrpashqtf 72   human
1U04_A     153 XKTLWELVNkdpk--------------eleEFLXTHKe-NLXLKDIAsp-----------lKTVYKPCfeeytkkpk--- 203  Pyrococcus furio...
1Z26_A     153 MKTLWELVNkdpk--------------eleEFLMTHKe-NLMLKDIAsp-----------lKTVYKPCfeeytkkpk--- 203  Pyrococcus furiosus
Q9UPY3     876 DSSTLDIDFkfmedieks---earigipstKYTKETPf-VFKLEDYQdaviipryrnfdqpHRFYVADvytdltpls--- 948  human
BAD34005   784 ANNKHMTHChscrdidl------lqtkdgpFCRCILK--NSIVCTPHn-------------NIFYVISgfldldansr-- 840  Japanese rice
XP_543449   80 QDHVVDTRQylehvrest---tgtlgrpvkLFTNHFRvtSRPQQVTYk------------cNIDYMPDiedgknnprt-- 142  dog
AAH25995   387 NDCVLDVMHaiyqqn---------kehfqdECTKLLV--GNIVITRYn-------------NRTYRIDdvdwnktpkd-- 440  human

Feature 1                   #   #                             #                          # #   
1T2S_A      71 ---tfehdgkkvTIASYFHSRnyp-------------lkFPQLHCLNVGss--------------------ikSILLPIE 114  fruit fly
1SI2_A      73 plqlesgqtvecTVAQYFKQKynl------------qlkYPHLPCLQVGqe--------------------qkHTYLPLE 120  human
1SI3_A      73 plqlesgqtvecTVAQYFKQKynl------------qlkYPHLPCLQVGqe--------------------qkHTYLPLE 120  human
1U04_A     204 ---ldhnqeivkYWYNYHIERywntpeaklefyrkfgqvDLKQPAILAKfaskik-------------knknyKIYLLPQ 267  Pyrococcus furio...
1Z26_A     204 ---ldhnqeivkYWYNYHIERywntpeaklefyrkfgqvDLKQPAILAKfaskik-------------knknyKIYLLPQ 267  Pyrococcus furiosus
Q9UPY3     949 ----kfpspeyeTFAEYYKTKynl------------dltNLNQPLLDVDhts-------------------srLNLLTPR 993  human
BAD34005   841 ---lpqhdgtvvTYKDYFKTRhgl------------tltFENQPLLAGSkhvkvrnflhnyyykkekepgdrySVELPPE 905  Japanese rice
XP_543449  143 --kfkksggaeiTFVDYYREQynt------------evtDLTQPLLISKgkwk-----------------ksqQDFDTNF 191  dog
AAH25995   441 --sftmsdgkeiTFLEYYSKNygi------------tvkEEDQPLLIHRpserqdn----------hgmllkgEILLLPE 496  human

Feature 1           
1T2S_A     115 LCSIE 119  fruit fly
1SI2_A     121 VCNIV 125  human
1SI3_A     121 VCNIV 125  human
1U04_A     268 LVVPT 272  Pyrococcus furiosus DSM 3638
1Z26_A     268 LVVPT 272  Pyrococcus furiosus
Q9UPY3     994 HLNQK 998  human
BAD34005   906 LCRII 910  Japanese rice
XP_543449  192 LSVSR 196  dog
AAH25995   497 LSFMT 501  human

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