1VMG


Conserved Protein Domain Family
NTP-PPase_SsMazG
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cd11535: NTP-PPase_SsMazG 
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Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria
This family includes a MazG-like protein from Sulfolobus solfataricus (SsMazG) and its homologs from archaea and bacteria. Although its biological roles remain still unclear, SsMazG shows significant sequence similarity to the NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, SsMazG contains a single MazG-like domain. It is predicted that SsMazG might participate in house-cleaning by preventing incorporation of the oxidation product 2-oxo-(d)ATP (iso-dGTP), a mutagenic derivative of ATP, into DNA.
Links
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Statistics
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PSSM-Id: 212142
Aligned: 29 rows
Threshold Bit Score: 93.4271
Created: 1-Sep-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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metal binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Structure:1VMG; Sulfolobus solfataricus MazG protein binds Li+, contacts at 4.0A
  • Comment:Most superfamily members require the divalent ion, such as Mg2+, for enzyme activity.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #  #                           #  #                 
1VMG_A        20 LQSKXKEXYFEKDs-qRGIYATFTWLVEEVGELAEALLSnnl------------dsIQEELADVIAWTVSIANLEGIDIE 86  Sulfolobus solf...
ZP_01115159   13 LQHYVRELEAERGfedQGVLDKCLMLGEEVGELFKAIRKqqglktd---pnstigdIDGELADVLIFLCSIANRCDVNLE 89  Reinekea sp. ME...
NP_900996     13 YQRYVSELEEERGfsqQNARDKCLLLGEEIRELFKAVRKaegmgid---anekvaeLEGELADVFIYLCAIANRFDIDLG 89  Chromobacterium...
NP_602745     21 IQSYIKEIMKMRGfnkEKSSDKILLLVEEVGELAKAIRKnerklgidktkeynyssIESEIADVFIVLLSICDILNIDLF 100 Fusobacterium n...
YP_003266117 156 LQHYVHQVVVDRGfddESPRDIMLLMVEEVGELAKALRKyiglkida-dkadryntLQDELADVFIYLLDLASGCDIDLY 234 Haliangium ochr...
YP_002753774 193 FQEYYRRAAIQRGyskEGPKECLLLMVEEVGELARAVRKreklvrh---asyeavsESHELADVFLYVVHMANVLGIDLA 269 Acidobacterium ...
EHI86362      13 LQRYVAAMEVERGfsdQSVYEQTWRLLEEAGELARAVRKnngqrtl---tgeligsVDEELVDVLIFACSIANRLGIDLT 89  Frankia sp. CN3
NP_821500      6 AQKLAWENKINQGfntTDIPLEFGLLNAEVGEAFTAWRKgl-------------pdHGEELADVFLYLVAIAEMQGVDLG 72  Streptomyces av...
ZP_04440974   14 LQEHIIANKVKHGwntTDTNFEMLLAYHEMAELTTALLKhdq------------anIAEELADVTIYLLGIAEIKGIDLA 81  Lactobacillus r...
BAJ19053       6 LQRLVWENKVRKGyntTDVPLEFCMLQENAATAFTAWRKqk-------------elLGEELADVVLYATSIAEMAGLDLL 72  Streptomyces sp...

Feature 1                
1VMG_A        87 EALKKKYK 94  Sulfolobus solfataricus P2
ZP_01115159   90 QAFLSKEA 97  Reinekea sp. MED297
NP_900996     90 MAFRRKEA 97  Chromobacterium violaceum ATCC 12472
NP_602745    101 KAFLDKEE 108 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
YP_003266117 235 EAFFAKES 242 Haliangium ochraceum DSM 14365
YP_002753774 270 DVVRDKET 277 Acidobacterium capsulatum ATCC 51196
EHI86362      90 DAIRAKEA 97  Frankia sp. CN3
NP_821500     73 EEVRREIE 80  Streptomyces avermitilis MA-4680
ZP_04440974   82 QAVNDKVT 89  Lactobacillus rhamnosus LMS2-1
BAJ19053      73 HEVKKKVD 80  Streptomyces sp. SANK 62799

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