Conserved Protein Domain Family
SepH

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NF040712: SepH 
septation protein SepH
Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.
Statistics
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PSSM-Id: 468676
Aligned: 23 rows
Threshold Bit Score: 238.513
Created: 11-Oct-2024
Updated: 3-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_106206837   1 MQDLRLVGVHDDGEHVVLVATDG-SRYRLRVDE----ALRAAV-------------------------------RRDRA- 43  Kineococcus rhi...
WP_181399482  12 MPELRVVAVSNDGTRLVLKAADS-TEYTLPIDE----RLRAAV-------------------------------RNDRA- 54  Streptomyces
WP_081982659  12 VPELRVVAVSNDGSRLVLKAADS-TEYFLPIDE----RLRAAV-------------------------------RGDRP- 54  Streptacidiphil...
WP_020555840  12 MPELRVVAVSNDGTRLVLKAADG-TEYMLPIDE----RLRAAV-------------------------------RGDRA- 54  Embleya scabris...
WP_179518088   1 MAHLTLAGTSEDGRRLRLVDTEG-AEHTLDVDD----RLRAAL-------------------------------RGAPA- 43  Nocardioides pe...
WP_194786229   1 MIELELLG--ANGGSVVMTDQAG-ERYSLVIDD----ALRAAV-------------------------------RRDHPg 42  Actinomyces hal...
WP_052109555   1 MMDLRLIGVHEDGEHVLLSDAEG-KRYRAPLDE----AMRAAA-------------------------------RRDRP- 43  Knoellia sinensis
WP_027013096   1 MRELHLVAHESNATSLVLCAEDSgEQFFLAVDD----SLLEILtaptpqtfep------------qeatpepveEPDDS- 63  Corynebacterium...
WP_013170000   1 MIELELLGLHPDGNQLSLNDAQG-NRYLLPITD----SLRAAL-------------------------------RKDTQ- 43  Arcanobacterium...
WP_035107083   1 MRELFLASSESSETSLVLRTDDG-EEFSLAVTDdvreALRPLVqsqdnaedaadtedkqasastasalsstpltTGGAG- 78  Corynebacterium...
WP_106206837  44 ----RLGQLQIQMEA--------------QLRPRDIQARIRAGESAEDVAAAGGLTVEHVRRYEGPVLAERAHVAGLARR 105 Kineococcus rhi...
WP_181399482  55 ----RLGQIEIEVES--------------HLRPRDIQARIRAGASAEEVAQMAGIPVDRVRRFEGPVLAERAFMAERARK 116 Streptomyces
WP_081982659  55 ----RLGQIDVES----------------HLRPRDIQARIRAGASAEEVAQLAGISVERVRRFEGPVLAERAFMAERARK 114 Streptacidiphil...
WP_020555840  55 ----RLGQIEIEVES--------------QLRPRDIQARIRAGATAEEVAQLAGIPVDRVRRFEGPVLAERAFMAERARK 116 Embleya scabris...
WP_179518088  44 ----RTGQMETRVDSsd-----------nALRPRDIQARVRAGESPEAVAEAAGTPVERVLVYARPVLAERAHVADRAQR 108 Nocardioides pe...
WP_194786229  43 slprQSQTPEPEAAPt------------tPARPKDLQALMRAGASAEEVAAATGQDVEHVRRFEGPVLAERGWAVEQARL 110 Actinomyces hal...
WP_052109555  44 ----RLGQLQIEIDG--------------GLRPRDVQALIRSGLSTEEVADRAGWTIQKVQRFEGPVLAEREYIANLARA 105 Knoellia sinensis
WP_027013096  64 ----PPPEPPIEQIPvpqqdpeqhrsgplTMRPREIQERIRGGASISEIAEAIGVRESRIEPFAHPILLERSRMAELAKR 139 Corynebacterium...
WP_013170000  44 ----QVETPAEELK---------------PMSPREIQAHIRSGMSVADVCELSSLPASQVSAFAHPIFAEREYTTNRAQN 104 Arcanobacterium...
WP_035107083  79 ----APKTKEAEPEPv-------------KLRPSEIQNRVRAGASAEELAEELGVPESRVEPFAYPVMLERNRIAEVAKQ 141 Corynebacterium...
WP_106206837 106 T---------PYGRgagtgSLDDVVVARLSARAVDPEGARWDAWRTEEGGWIVQCEFVAGGRGRVARWGFDP-A---ARV 172 Kineococcus rhi...
WP_181399482 117 Tpvrr--pgeNSGP-----QLGEAVQERLLLRGAEKDTVQWDSWRRDDGTWEVLLVYRVAGEVHTASWTYDP-P---RRL 185 Streptomyces
WP_081982659 115 Ttvrr--qgeSTGP-----QLGDAVSERLLLRGAEKDSTVWDSWRRDDNTWEIVLQFRADGLQQQARWTYDP-P---RRL 183 Streptacidiphil...
WP_020555840 117 Tpirr--qgeTTGP-----LLGEIVTERLHLRGADSESVQWDSWRRDDGSWEILLLYRADGEMRSASWSFDP-P---RRL 185 Embleya scabris...
WP_179518088 109 Ssvrr--rsgEPAPgg-arTLGDLVALRLRALGTPDAEVLWDAWRRDDGRWSLHAAYDAPGRAGTASFTYDP-P---GNY 181 Nocardioides pe...
WP_194786229 111 Crig----weKDSP-----LLGELVVDRLATRGVDPESLEWDALREGRQPWQILVTFLEGDTEHRATWTLDL-P---ART 177 Actinomyces hal...
WP_052109555 106 VivgqtrpgsRAGNqtaeqSLGSRADERLKERGVLAERVRWDSLRLDDGRWTVTAHFPAGGRERIASWTFDP-R---LKS 181 Knoellia sinensis
WP_027013096 140 Alp-----vrDDGPas--lTLWEILATAFAAREIDLTTSKWDSYRDASGQWVVRVSWQSGISENTAEWSYHPkGtaaSPT 212 Corynebacterium...
WP_013170000 105 Frl-----nrETGSm----TLEELVISRLVPRGITATDITWDSTRNPGDPWVLTACYTEKGEEHRATWVINL-R---GQS 171 Arcanobacterium...
WP_035107083 142 Ahp-----vrEDGPas--lTLWEILATAFAARGHSLSEADWDAFRNQGEPWIVRITWKSGLSENEAEWTFKQ-SmstPAT 213 Corynebacterium...
WP_106206837 173 LSAHDDEARWLSEeepAEPGPl---PARRLVSVPGEGTRPGaervydveadggvrangTDRLLDALESARGVRPEQAGSA 249 Kineococcus rhi...
WP_181399482 186 VQAVDDEARALIG---ETDDTiaaaPEPSFPFVPRIARLPRdrp-----------ldrALDRQLDHRQLERASAPAEPEE 251 Streptomyces
WP_081982659 184 VQPIDDEARALIGe-pQERGG----EEPTFPFVPRIARLPGadr------------gmGMRPLAPERPPAGRMGPAERMA 246 Streptacidiphil...
WP_020555840 186 VTTNDDEARSLIGe-hPAASEtpfpFRPRLATIPRESDD-------------------DAITSLLDAVPGLRGEPQTQSV 245 Embleya scabris...
WP_179518088 182 VTLDDDDARWLVG---EEVAA----PEPE-----------------------------AAGAAATDDLEAARRRRRTVVD 225 Nocardioides pe...
WP_194786229 178 VAARDDEARWLTE---AGAGG----RRPAVFDQDSEAPGASaqer----------asyGSVPAEDSPAPAPEPADLDHAD 240 Actinomyces hal...
WP_052109555 182 LLSGNDEARWLSEdstGDSAI----PTPHVATNANRASAVFd----------------VEAAGGVKEEAAAEGADSSDSS 241 Knoellia sinensis
WP_027013096 213 VVARNASAADLID---PQFSR----PVRSLPhfd---------------------------------------------- 239 Corynebacterium...
WP_013170000 172 VEATNDEATWLTEthiPTPTS----PWRPLETSSKPALVPAa----------------DAVNEEYEPQPAMPKITALDAQ 231 Arcanobacterium...
WP_035107083 214 VEARNSVAADLTD---PDFVQ----PVRSLTSVGRGERY-------------------DEAIDGDEPQNVSEitd----- 262 Corynebacterium...
WP_106206837 250 PEPAAGTgagsap---rvdaltADPPPAHPADSAPGDVEDRTVLSGgglepevpeaaevde------------------- 307 Kineococcus rhi...
WP_181399482 252 ERDSLTSl-------------lEAVPSFRGDMVVPEQPDSEPAEEA---------------------------------- 284 Streptomyces
WP_081982659 247 PPERHVPerh---------vpdRHVPERLVEPPAVAAAAAVPVTAErepltglmdvv----------------------- 294 Streptacidiphil...
WP_020555840 246 SPGPMRI---------------DVTALAERPRVGSIERSERAERPErierveraerier--------------------- 289 Embleya scabris...
WP_179518088 226 EADQELPl--------------GADALALVRSADPDDPGPGDPGPGaapgagpdestvdlte------------------ 273 Nocardioides pe...
WP_194786229 241 KAPTGTSsapvds---dtdallADLASNRGRRVEVEVPEDDEVDPGsahaaeaddetsphgqarvfsmqerrrafvgnhp 317 Actinomyces hal...
WP_052109555 242 DSSGPSAepidlmaamreqstrSRRSHGRRRSSPTHTPVDESPRDDalpleeltmdpaeape------------------ 303 Knoellia sinensis
WP_027013096     --------------------------------------------------------------------------------     Corynebacterium...
WP_013170000 232 PASAGTPsi------------dDVLASLDFQRGKVRQMPGEAFFDGahpaasdtysvrda-------------------- 279 Arcanobacterium...
WP_035107083     --------------------------------------------------------------------------------     Corynebacterium...
WP_106206837 308 ----pgeadggtdgvpdagALPETAPEAEVEVEQPPaeaeqAPADTAPQTPAENPTEPGNprrrnrsARRsgsgaKRPSV 383 Kineococcus rhi...
WP_181399482 285 -------------------EAEEPPAPAASAGAGAAyadvlMPRAVSGHRDRLTGTTDRQaea-dgvRPG-----RRAAV 339 Streptomyces
WP_081982659 295 ---------psqgtqpvedEPVEPEAPAAAVGAGSAyadilMPRAASPHRDRLIGSTDRQaea-dgvRPG-----RRAAV 359 Streptacidiphil...
WP_020555840 290 ------aerserperaepiEEEETQAPAAAAGAGSAyenvlVPRGVVGPHRERLVGSTDRqaeadgvRPG-----RRATV 358 Embleya scabris...
WP_179518088 274 ---taarvrgerdaaapttPATAPAGSSAAPPSDPA-------EAPADAPVEEQPARRPG-------KRG-----RRASV 331 Nocardioides pe...
WP_194786229 318 agsklhqgedgssgqpapgARPQPDASRAQMDAPTAevaevTERGTQGALPEMPPAPKAKp------KRR-----PRRSV 386 Actinomyces hal...
WP_052109555 304 ----ppaargkhpvsahldDRAHDVDDVTSDEDSDStetlnAAEARETAKPGPPAQAPARks---gsRKA-----GRPTV 371 Knoellia sinensis
WP_027013096 240 -----------------vpTTNEQTAPIPIVNEEPQqhgdgILESDEKIRPQPAKTPEPK--------RR-----RKAVT 289 Corynebacterium...
WP_013170000 280 ------tvvdistrkastpDKARSAESAPTSSTAPT-----ADSADSPAHSLGKKALNRKds----kRRR-----NRPSM 339 Arcanobacterium...
WP_035107083 263 -----------------ltEPTSPPEEEEEFLQNPD--------------------PKPA-------KRR-----RKAVT 293 Corynebacterium...
WP_106206837 384 PSWDDIMFGTKKD 396 Kineococcus rhizosphaerae
WP_181399482 340 PSWDEIVFGTRRK 352 Streptomyces
WP_081982659 360 PSWDEIVFGTRRK 372 Streptacidiphilus albus
WP_020555840 359 PSWDEIVFGSRRK 371 Embleya scabrispora
WP_179518088 332 PSWDEIMFGGGDK 344 Nocardioides perillae
WP_194786229 387 PSWDEIVFGAKPE 399 Actinomyces haliotis
WP_052109555 372 PSWDDIMFGGGRS 384 Knoellia sinensis
WP_027013096 290 PHWEDVLLGVRTN 302 Corynebacterium freiburgense
WP_013170000 340 PSWDEIVFGTPKE 352 Arcanobacterium haemolyticum
WP_035107083 294 PHWEDVLLGVRSN 306 Corynebacterium camporealensis
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