1DBX,1DBU,2DXA


Conserved Protein Domain Family
YbaK_deacylase
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cd00002: YbaK_deacylase 
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This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.
Links
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Statistics
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PSSM-Id: 237976
Aligned: 105 rows
Threshold Bit Score: 159.925
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative deacylase active site [active site]
Evidence:
  • Comment:A mutation of the conserved lysine to arginine in Haemophilus influenzae YbaK abolishes activity.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     #                                 
1DBX_A        1 MTPAIDLLKKQKIPFILHTYDHDpnn-qhfGDEAAEKLGIDPNRSFKTLLVAEngdqkKLACFVLATANXLNLKKAAKSI 79  Haemophilus infl...
ZP_00766369   4 KLNSMRLLERHHIAYTVHEYEYNda---ydAQTIARMIGVPASQVFKTLVVGGag--vRPILAMVPADAQLSLKRLAALI 78  Chloroflexus aur...
ZP_01516742   4 KLNSMRVLERQQIPYTVHDYDPTlp----dAVAVAEAIGIPAAHVFKTLVAKSd----RPLLAMVPAHCQLDLKRLAVLA 75  Chloroflexus agg...
YP_812852    13 KTLVEKILDQHKIAYEQHISEISedh--gvAQVGTGKPVLDGHPVYKTLAVNGnk--tGPIVGVVPLSGHLDLKKIAKAS 88  Lactobacillus de...
NP_965197    12 KTLIEKMLDQQKIPYKQLQFATVqkg--dvKQMDTSILDDEEALVYKTLVCEGnk--nSPVVGVVPVTEHLSMKKLAKAS 87  Lactobacillus jo...
YP_806772    10 KTLVEKMLDKAGIAYVPYEFPTEevg--dvAQLTIDHLDVPEHQIYKTLVLTGnk--tGPVVGVVPLDRHVDYKKLSKVS 85  Lactobacillus ca...
YP_819407     3 KTLPEQVMDKHKVKYEPLELNILdkt-pvqRDAILETFHVKHDDIYKTLAAHGdk--tGPIVAVLPITKHLSLKKLAAAS 79  Leuconostoc mese...
NP_358482     4 KVKIKKTLVEQILSKAAIPHQGIqi----nALEGELPQGYERDQIFKTLALLGdk--tGPIIGIVPITQHLSEKKLAKIS 77  Streptococcus pn...
YP_536029    12 KTNEERVLDQHNIEYEETSFNWIeqg--kdALKEAAELGVEPESILKTIVLQGkgdpkDFFVVCLPIVHEMDLKLVAQQL 89  Lactobacillus sa...
YP_811315     9 KTQVEQLLDKNKIPYQSLELNVLnqssteiKKNLSKAGIPRESLIYKTLASNGdk--sGPVIAVLPVTKHLDEKKLAAVS 86  Oenococcus oeni ...

Feature 1                            ##                              #                          
1DBX_A       80 GvKKVEXADKDAAQKSTGYLVGGISPLGQk----kRVKTVINSTALEFETIYVSGGKRGLSVEIAPQDLAKVLgAEFTDI 155 Haemophilus infl...
ZP_00766369  79 GvKSLDLLPRADVERLTGLQIGGIGALALta---kGWTSYLDESALQYPVVYVNAGKRGILLGLAPTELVRVVgAKVGAI 155 Chloroflexus aur...
ZP_01516742  76 GvKRVEMAPHVEAERLTGLRVGGIGALALia---kRWPSYLDESALVPSKIYVNAGQRGVMIGIAPSDLVRVVgATVGAI 152 Chloroflexus agg...
YP_812852    89 GnKKCEMIPLKQLEKTTGYVHGANTPIGIyh--skKFPIFLDESVLKEDGIWVSSGEVGRSVMVNPLDLQKLVkATVADL 166 Lactobacillus de...
NP_965197    88 GnKKCELLPLKKLVATTGYVHGANTPIGIyq--khHFPIYLDSSMKEHDHIAVSSGEVGRSIMINPDDLQKVTnATFVDL 165 Lactobacillus jo...
YP_806772    86 GnRKVGMVPLKDLMKTTGYEHGANTPIGIhe--rhKYPIFISQEAEDQATIIVSAGKVGRSVGIDPKILAQFVdAQFADI 163 Lactobacillus ca...
YP_819407    80 GnKKVAMLPLKELQRTTGYIHGANNPVGIwq--nkHFPIYFDLSAAEQPFILVSGGELSRSDKINPRDVASLVgAEFVDL 157 Leuconostoc mese...
NP_358482    78 GnKKVSMIPQKDLEKTTGYIHGANNPVGIrq--khNYPIFIDKIALDLDRMIVSAGEVGHSIIVAPQDLASFVkADFVDI 155 Streptococcus pn...
YP_536029    90 GkKQVHLADNKNLINITGYIHGANTPIGIha--fkGFPIYFDERIKPFEIISVSAGKVGRSVRLKQEDLVKLVnGKYIEV 167 Lactobacillus sa...
YP_811315    87 GnKRTEMIPLKELQKTTGYIHGANNPVGIwhnhhgKFPIYFDKTSLSDELIYVSAGELNRSDLINAKQVAELIgASFADL 166 Oenococcus oeni ...

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