Conserved Protein Domain Family
Virul_fac_BrkB

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pfam03631: Virul_fac_BrkB 
Virulence factor BrkB
This family acts as a virulence factor. In Bordetella pertussis, Swiss:Q45339 is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.
Statistics
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PSSM-Id: 460996
Aligned: 93 rows
Threshold Bit Score: 69.966
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Haur_2802  22 VDDCSRMAASLAYYAVFSIFPLILLLLSIL-GFwLRlqgdTNTNAEETLVNSLMQVfqtspqvgvDDS-AIrTALTEIL- 98 
Q73RD9         42 NNDLLTTAAAGAYNFLMSALPIFILTLTILlR--------VLKQSPQQIKEALRAL----------------SIFQNTVn 97  Treponema dent...
WP_012200691   18 EHDITGSAAKATYYLLLSFFPLCLLLLPLF-------------DDTRILTIF-------------LPSsVA-VLLEDIVk 70  Lachnoclostrid...
WP_022416220   20 KDHVGAYAAQAAYFFMLSLIPIILLLITLV-QY-TP-------VTKADVMTAVLQV---------FPKsVD-SLITSIV- 79  Dorea longicatena
Q8DQP1         28 asdSELTSVAVAYYWLISIFPLLLVVVNIL-PY-FQ-------IPVGEFLGFMKDV---------LPPsLY-EGVEKIA- 87  Streptococcus ...
Q1GB87         25 QGEIFQSSIVIAYYILFSIFPIVIIVGNAL-PW-FH-------LDTGPIADYLEMI---------FPSdVA-RYIIPIV- 84  Lactobacillus ...
Q1WSQ6         23 EADINSTSITIAYYALLAILPTIILLGNIL-SI-IN----LK-E--ADVLNGLQVI---------VPSnVF-TTLKPII- 82  Lactobacillus ...
Q03Q72         25 MANVSDSAVVLAYYTLLSLFPALLVIASLL-PY-LN----IQ-T--ETVLESIEPM---------VPEsIF-SMLKPII- 84  Lactobacillus ...
Q04DP4         23 QGNVNNNAIILSYYLLLSLPPIILILGNLL-AH-LK----IG-V--RTILNYIIQI---------TPSdMS-NIIKPII- 82  Oenococcus oen...
Q3Y2R2         26 DSEMSTTSVVVAYYLLLSLFPLIIAFGNIL-PF-LH----ID-Q--ETVLTYLREV---------IPEtVY-QFIGPAI- 85  Enterococcus f...
jgi:Haur_2802  99 K-SLS----QQAgTNAPIALATTF---FAASGIFVQIDKAFDVIWDIqpQQGN-FlhtvksTLIERGKAFALVL----VI 165
Q73RD9         98 LdRFFhfllNVN-SFSFFEFIVLIfvlWMARRFFATIQHSIRKVY-------R-K------KIKITPLKTSLIVilgeII 162 Treponema dent...
WP_012200691   71 P------------ELAFQTTSIVIi-lWSASASIWALMTGIYTAYTGekKL-K--------LIQGRIRAILLIF----IL 124 Lachnoclostrid...
WP_022416220   80 N-QVY----NQS--GGIISLTIIVa-lWSAGKGVLALTTGLNCVYDC--KETR-N------YIILRIRATFYTV----AF 138 Dorea longicatena
Q8DQP1         88 R-EVL----TQP-STGLLSFSVLSa-lWSFSKSINFLQKAFNKAYGV--EKSR-G------LISHQMLSLLVSF----GL 147 Streptococcus ...
Q1GB87         85 D-TLL----KSN-STSYISFGAIMa-lWSMSCMVNAVRIGMNRLYGVhnKELKlGfw---hFIWNRTLTVIFSA----LM 150 Lactobacillus ...
Q1WSQ6         83 E-TML----KKG-SGGIASVSGILa-lWAVSRGINALKNGLNMAYGVgkGTGT-G------AVLGRIFSIFITV----VL 144 Lactobacillus ...
Q03Q72         85 H-SFL----NTR-SGGVLSIGVIVa-lWSSSRAVAAFQRTVNGAYGV--AKNQ-N------ALVNRIVAFFWMV----AL 144 Lactobacillus ...
Q04DP4         83 N-SFL----TNG-SNSSLSIGILVt-iWSASGLIATLRRCFNQIYNS--SSKQ-N------AIVSRILSFILLL----LA 142 Oenococcus oen...
Q3Y2R2         86 K-DLL----TQS-SGGLLSVSALAa-lWSASQSINALQIAMNKAYGV--ENRK-N------FLIVRFFSLIVIV----LF 145 Enterococcus f...
jgi:Haur_2802 166 GLLLISSLILSSVLQA--LEnlsksfdlPGVg------vG---WQIFTFATAFAIN-VLVFFLLFFAMPKP-KMRWRDVL 232
Q73RD9        163 VVILLVFLFIFLITGSavFRs-------DFAqpvfspnlFsllRNLFRF-IPVIFM-QLFVCLIYYWMPPI-KPSFKTAL 232 Treponema dent...
WP_012200691  125 VAALLLCVSVTIFSKSl-----------IYWiiedfvhlSyglMNGLRL-VILILIiYFIVICLYQFTPNL-KVRVRSIS 191 Lachnoclostrid...
WP_022416220  139 IIVIIFLLVLSVFGNTlnLFvt-----eHYPlmer----fvdqIMQIRGIITPVLL-FVFTMMIYKFLPNH-IVQLKVQL 207 Dorea longicatena
Q8DQP1        148 QFLFAFALFLILFGQMilALl------aHYWtkdgi---iyqaLQGLAGPLIYALL-FAILVMLYYFLPNLsNRKISYTL 217 Streptococcus ...
Q1GB87        151 VTMFILLALIVVFGQEvlHFla-----pYFNlpla----widkLSSYRWLVLLVLI-LIGVYYLNAVAPNV-H-FKKALF 218 Lactobacillus ...
Q1WSQ6        145 GLLIVALFLVFSFGQIalDYit-----pLLNlstn----widlFMRWKWPTAAIGI-FVIIILIYTLIPNA-KLHFILVL 213 Lactobacillus ...
Q03Q72        145 IAFLFVLMLFFSFGQIilEQla-----pYLHvphe----iigyINAAKWPVTFLVV-LLVLMILLYFVPSA-KLKWRFVW 213 Lactobacillus ...
Q04DP4        143 FLLFALLLSIMLFGQYllKLlk-----nNFGtslg----wltsLLGAKNLIGLVGL-FSLLILIYYFVPQA-KIKWRYVW 211 Oenococcus oen...
Q3Y2R2        146 MIAISGVTIVLGLGQLilDAiq-----pIVQipvn----fidqFQTLKWPITLVAL-FVIMFLIYLIVPNA-QLKLKTII 214 Enterococcus f...
jgi:Haur_2802 233 PGAILTAALWEIGKIVLSLFLGG-N---KYTAST-TVAAFIALLA--WIYYASQIIFFGAEFCRVYTDW 294
Q73RD9        233 LSSAACTLSYYFVKIFFS-FFRStV---KFTFVYgLFTNVILVLIqvWFFFFFFVFFAQFMYVNQFFNS 297 Treponema denticola
WP_012200691  192 IGAIITAIGWVITTWGFEVYMKLfN---NYSALYgSIGAFLGLTL--WLYIVSIVLLCGAEINVMLSER 255 Lachnoclostridium phytofe...
WP_022416220  208 MGAAFSAVGWMIVSWIFSVYLDIfK---GFSSMYgSLTTIVLIML--WLYFCMYILLLGGEVNVILRdm 271 Dorea longicatena
Q8DQP1        218 PGSAFVLLVILGVLTLFSSYLNYyVhhlVDVRILgSV-LLVVMMF--WFILIAKIVILGAVINASMQSl 283 Streptococcus pneumoniae R6
Q1GB87        219 PGTIVTVAGWEALSYLFSFYLKNfP---VKWENYgIVGNFIIFML--WLNLLAILLLFGTAVNVSLDQl 282 Lactobacillus delbrueckii...
Q1WSQ6        214 PGAILATIGWLGLSQGFSIYVRYfT---RTLLSYeALGTFIVLLL--WLNYTGWVIMLGSVVNAGLEYY 277 Lactobacillus salivarius ...
Q03Q72        214 PGALTATVGWLLLSQAFSLYVKYfV---HNMDSYrTIGTFIVLMF--WLDFTGLILMFGAVLNAAIQDM 277 Lactobacillus brevis ATCC...
Q04DP4        212 IGAVFTSLGWLLLAQGFQLYVEYfA---QRVSSYqTIGSFILLMF--WLNFSSSIILIGGVINASCQNY 275 Oenococcus oeni PSU-1
Q3Y2R2        215 PGTIFATVGWMLLSQVFSIYARYfA---TRISGYqIIGSFIVLML--WLNFAATIIILGGIINAVVQEY 278 Enterococcus faecium DO
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