4JSP


Conserved Protein Domain Family
PIKKc

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cd05164: PIKKc 
Click on image for an interactive view with Cn3D
Catalytic domain of Phosphoinositide 3-kinase-related protein kinases
PIKK subfamily members include ATM (Ataxia telangiectasia mutated), ATR (Ataxia telangiectasia and Rad3-related), TOR (Target of rapamycin), SMG-1 (Suppressor of morphogenetic effect on genitalia-1), and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP, ATM and TRRAP, C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints, genome surveillance, mRNA surveillance, and translation control. The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Statistics
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PSSM-Id: 270708
Aligned: 12 rows
Threshold Bit Score: 271.452
Created: 24-Aug-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ## # #                # #  #                                        
4JSP_B     778 IQSIAPSLQVITSK-QRPRKLTLMGSNGh-eFVFLLKGHEDl------RQDERVMQLFGLVNTLLandptslrknLSIQR 849  human
CAA94790  2189 IHDFSDKVKVLHSN-TKPVIIKLTTKTGr-iVRLICKKDDDl------SKDYHFTKMVEMCNDLLmkdeqtriqkMTATT 2260 Caenorhabditis e...
CAK80893  1148 ILQIYPQMKIAPSK-DKPKKIQVECSDSsikYLLLKNEVQDskssgdtRREQRIILMLQFFNTLLep------lqLKYPL 1220 Paramecium tetra...
EAS06453  1772 MEKFDDVVRIMSSK-QKPKLLTVQCSDGt-kKKFLIKSQTQse----nVYEQRTSELISFLNLILykeq---lgfYEMPS 1842 Tetrahymena ther...
1235902   2293 IAGFDDMVEILASL-QKPKKISLKGSDGk-fYIMMCKPKDDl------RKDCRLMEFNSLINKCLrkdaesrrreLHIRT 2364 human
AAF20175  1210 IVSFKPEFRLAGGL-NLPKIIDCVGSDGk-eRRQLVKGQDDl------RQDAVMQQVFQMCNTLLqrnsetrkrkLTIRR 1281 African clawed frog
Q8BKX6    2119 IHSVGGTITILPTK-TKPKKLLFLGSDGk-sYPYLFKGLEDl------HLDERIMQFLSIVNTMFatinrqetprFHARH 2190 house mouse
CBY22988    37 IVSILDEVLELSSQ-QRPKRLNFLGSDGh-sYSFLLKKGDDl------NLDSRIGETFELFDYLLqrekesrdanMTIRS 108  Oikopleura dioica
EMH75405   517 IKCIENSFRILNSL-QKPKKITILSKDKsepYYFLCKGKDDi------RKDNFVQELFGALNHLFetshysqqynLKIQT 589  Entamoeba histol...
ELP89028  2025 IKSINNYYNVFASL-QKPKKINILTYNEnvsFNFILKSDDDi------QKDKMVEELFGALNHLFetspqtsmfgVSVRT 2097 Entamoeba invade...
P78527    3719 IAGFDERVTVMASL-RRPKRIIIRGHDEr-eHPFLVKGGEDl------RQDQRVEQLFQVMNGILaqdsacsqraLQLRT 3790 human
Q9Y4A5    3496 IARFMPRVEIVQKHnTAARRLYIRGHNGk-iYPYLVMNDAClt---esRREERVLQLLRLLNPCLekrkettkrhLFFTV 3571 human
Feature 1      #           ####    #                                                           
4JSP_B     850 YAVIPLStNSGLIGWVPHCDTLHalirdyrekkkillniehrimlrma-----------------------------pdy 900  human
CAA94790  2261 YSVIPLGkQGGIIEFMEGVTSFYetldklmgmtsgewleklkfwnt--------------------------------hm 2308 Caenorhabditis e...
CAK80893  1221 FASMSLNqLSQVIEWVTQTTTCReaigvstvgaknrq------------------------------------------- 1257 Paramecium tetra...
EAS06453  1843 YTILRLNsQSCIVEWVDDTLTLKtildqlwqekkqksqfyql-------------------------------------- 1884 Tetrahymena ther...
1235902   2365 YAVIPLNdECGIIEWVNNTAGLRpiltklykekgvymtgkelrqcm--------------------------------lp 2412 human
AAF20175  1282 YKVVPLShRSGVLEWCTGTVPIGeylvndkdgahkryrpgdygslqcqr---------------------------kmme 1334 African clawed frog
Q8BKX6    2191 YSVTPLGtRSGLIQWVDGATPLFglykrwqqreaalqaqkaqdsyqtpqnpsivprpselyyskigpalktvglsldvsr 2270 house mouse
CBY22988   109 YNVMPIGhKKGIIEWVDDLWAFKkclqpyferkghhmqhlqwtp------------------------------------ 152  Oikopleura dioica
EMH75405   590 YTALPMSeETGLIEWASNTIPMKslivesrtkdiityhklvakeg----------------------------------- 634  Entamoeba histol...
ELP89028  2098 YCVFPIAnCTGLLEFVSNTIPIKkfianrlptssdvkamtdk-------------------------------------- 2139 Entamoeba invade...
P78527    3791 YSVVPMTsRLGLIEWLENTVTLKdlllntmsqeekaaylsdprappceykdwltkms-----------gkhdvgaymlmy 3859 human
Q9Y4A5    3572 PRVVAVSpQMRLVEDNPSSLSLVeiykqrcakkgiehdnpisryydrlat------------------------vqargt 3627 human
Feature 1                                                                         # #          
4JSP_B     901 dhltlmqkvevfehavnntagDDLAKLLWLKSpssevWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDrlSGKILH 980  human
CAA94790  2309 kpmgkeertkyfrevackntpVVMGKWFRIQYpeagqWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHt-TGKCIH 2387 Caenorhabditis e...
CAK80893  1258 -------iynqtewkqlneqePKLNNYFFSQYqdpyiWYDAQQGFIKSMALWSAFQYLIGFGDRHCDNILIHe-SGELIH 1329 Paramecium tetra...
EAS06453  1885 --kldsdklsreewnkqkslpSVFQDFFNQRFldsqqWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKkiNGEIVH 1962 Tetrahymena ther...
1235902   2413 ksaalseklkvfrefllprhpPIFHEWFLRTFpdptsWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDslTGECVH 2492 human
AAF20175  1335 vqrgrfeekyqmflnvcenfrPVFRYFCMEKFldpamWFEKRLAYTRSVATSSIVGYIVGLGDRHVQNILIDeeSAELVH 1414 African clawed frog
Q8BKX6    2271 rdwplhvmkavleelmeatppNLLAKELWSSCttpdeWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDmtTGEVVH 2350 house mouse
CBY22988   153 psedepermksfndikkkagpPVFHQWFIENFptageWYEARSTYQKSLAVTSIVGSIIGLGDRHCENVQICqkTAEVVH 232  Oikopleura dioica
EMH75405   635 nqrkrvdlykkyilnssytlpPQFYSNFNHSFpiphhQIKARENYSKSMAVMSMVGSIIGLGDRHLENILLNtkDGNIVH 714  Entamoeba histol...
ELP89028  2140 --rltkeakirefkrytlkhsGVLYDKFNECFktphaQTEARCNYIKTTAVNSMVGALIGIGDRHLENILLDtkEGGVVH 2217 Entamoeba invade...
P78527    3860 kganrtetvtsfrkreskvpaDLLKRAFVRMStspeaFLALRSHFASSHALICISHWILGIGDRHLNNFMVAmeTGGVIG 3939 human
Q9Y4A5    3628 qashqvlrdilkevqsnmvprSMLKEWALHTFpnatdYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAqdTGKLNV 3707 human
Feature 1      ##                                                                      
4JSP_B     981 IDFGDCFEVAMTrekfpekIPFRLTRMLTNAMevtglDGNYRITCHTVMEVLREHk---DSVMAVLEAFVYD 1049 human
CAA94790  2388 VDFDMIFNKGETlgt-pelVPFRLTQNMINGMgevalDGEFRTVCEQALRVFRENsyeiEKYIADLPNLVAD 2458 Caenorhabditis elegans
CAK80893  1330 IDYECVFHKGKFlpv-peiVDFRLTKNLRYGMgylreQGQFRQILEQIIEMFQKHk---DIIFAFLDPYIYD 1397 Paramecium tetraurelia
EAS06453  1963 IDYALIFGSGKQlnv-petIPFRLTKNMEFALgsfksYGLFRKAMIDICMCFSKHl---DDIIGFWDCFTNE 2030 Tetrahymena thermophila ...
1235902   2493 VDFNCLFNKGETfev-peiVPFRLTHNMVNGMgpmgtEGLFRRACEVTMRLMRDQr---EPLMSVLKTFLHD 2560 human
AAF20175  1415 IDLGVAFEQGKIlpt-petVPFRLTRDIVDGMgitgvEGVFRRCCEKTMEVMRNNq---EALLTIVEVLLYD 1482 African clawed frog
Q8BKX6    2351 IDYNVCFEKGKSlrv-pekVPFRMTQNIETALgvtgvEGVFRLSCEQVLHIMRRGr---ETLLTLLEAFVYD 2418 house mouse
CBY22988   233 IDLNMIFLKGRTlkv-peiVPFRLTRNIIDGLgpaecDGLFRKSALITIRMAKNKg---KLLRTVFSLVLRD 300  Oikopleura dioica
EMH75405   715 IDFDMLFWKGEIlpv-petVPFRLTTNMIDCFgpqaeNGLFLDMCTVVLKTLRHNq---SVIISLTDSMLQN 782  Entamoeba histolytica HM...
ELP89028  2218 IDFDAIFFKGLLmnv-peiVPFRFTLNIRDCLgatkdEGLFLDVCTAALSVFRHHk---DVVMTFVEILWNY 2285 Entamoeba invadens IP1
P78527    3940 IDFGHAFGSATQflpvpelMPFRLTRQFINLMlpmkeTGLMYSIMVHALRAFRSDp---GLLTNTMDVFVKE 4008 human
Q9Y4A5    3708 AYFRFDINDATGdldanrpVPFRLTPNISEFLttigvSGPLTASMIAVARCFAQPn---FKVDGILKTVLRD 3776 human

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