Conserved Protein Domain Family
bact_immun_7tm

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TIGR01654: bact_immun_7tm 
bacteriocin-associated integral membrane (putative immunity) protein
This model represents a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins (TIGR01653). Others may be associated with uncharacterized proteins that may also act as bacteriocins. Although this protein is suggested to be an immunity protein, and the bacteriocin is suggested to be exported by a Sec-dependent process, the role of this protein is unclear. [Cellular processes, Toxin production and resistance]
Statistics
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PSSM-Id: 273736
Aligned: 7 rows
Threshold Bit Score: 492.337
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAC03468       2 YKKLERVLITLSIVLVSAFSMIIVINKHKQMFAGTNGGVLVLK----------AKSN-IKESIAEIAKKNNVLIAKQIMV 70  Lactococcus lac...
WP_010896461  19 IDLLGPDIVLSVLEEAATHHQVNLLRDVQLLGEGDKIALTTFAlltekspfleAIPLrHGSRLTSEDTRDGDLILSSRRT 98  Bacillus halodu...
WP_014931904  16 esTMKKLFILLSTFFLSFFLAWIIVLRAPQYLYASYDSVSLLRvkkd---tqePTREvFEQELENFANSEQSLIARRIVE 92  Streptococcus p...
WP_000870806   1 MKWFKLILDVTIFILIAILLFVYTYKENEEILPDTKYPIAVTDwn------kkYSKNeIYKRIDQFAKNENVAIYKSTSN 74  Staphylococcus ...
WP_009930898  10 LVTLIIGNVMFFNFISNTLSRDFLFKEQTVVQFKYKEDYQVSDfnnsiktfseTKNInIAQYTFLGERDLNIYGSNCQFA 89  Listeria monocy...
WP_000724262   6 nfcMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLYLKDinepaasvlrFFEDvSKEYKVSIIKTDSGDEVVKSGV 85  Streptococcus p...
WP_010905029   1 MNKVIKFVLLVLFIVISISSANIVKNNFVDKQIEKNYDVQDFTqiyl--pssiSSDKnLISLVEGVSAKTGASFIFRSTY 78  Lactococcus lactis
CAC03468      71 PSTDGKTDNQPTFQK--------------FGNGTLPKDFPE--QKNKEFIEDSNDSVYy-----FIFGKTLSSIDLSKYL 129 Lactococcus lac...
WP_010896461  99 KEDVEEIKGTIQTLSqtht-------rtvRPLHQFPNYVSPyaTYQVEQAGTVTKEQF------SATLADLFNHYLEDYV 165 Bacillus halodu...
WP_014931904  93 PSKDGTT--HFTYAT--------------YGQGTLPKEFQEasQESRERSDPLNSY--------LLLSGSLTKEKLADKL 148 Streptococcus p...
WP_000870806  75 YTNKNVDKDIYVFNK--------------SKAATITPFNAKynIHYLSDDEVLKKDIKgs---yFVKDKNFDVSKFINFL 137 Staphylococcus ...
WP_009930898  90 PNINLKKGDYPNKNQf-------------LANEESVDKKQSgvIYHPSKYWSLKVYDFg-----QIKNVGLSDTFYVSGL 151 Listeria monocy...
WP_000724262  86 FDKDTFPYQEFGISSldftt----dgegvYSNKEISNKLGTipTFLKAKPIQLMTFQTyikdtsRSLNGRYTITSTQEMD 161 Streptococcus p...
WP_010905029  79 GGVKNDGKGHADLLKmdskavfyktnyqtSDKKTFVSHGFScqLWSEPLKNITTVEQEnsdvyiKNKNIQTSLQDFLIAL 158 Lactococcus lactis
CAC03468     130 -N----E-----KGN-----TSMVSDN-DWRFQGITALL-----DT--RM-IVGLLLFLISYT-SILMANIIINLKKQGV 184 Lactococcus lac...
WP_010896461 166 -E----E-----LEP-----LTADDFAvQTEPSHVSTTF-----DP--TF-PKTLAWTLWGITgLMLMFYIMRNGKTVAI 222 Bacillus halodu...
WP_014931904 149 -G----D-----LGY-----KAIADRKiPPYSLAFRILL-----NP--LI-LISLAIFGLSFFaLV-IITRIKEMRAAGI 204 Streptococcus p...
WP_000870806 138 -K----E-----YG------VTAESYKiDHMMIAVGVIK-----QM--NI-VVPLSSLLIVYF-IYYIFEKNINFKAYAI 192 Staphylococcus ...
WP_009930898 152 dN----Q-----NTYqaflkEFEQYGEvTTKSVDVSWWK-----YI--NIpLLMTLLLCFAILfVFTYYYLRYSKQRLLV 215 Listeria monocy...
WP_000724262 162 -KdrivQ-----KWS-----DFFKIDQaTLLEPTYKSAVevinrDL--LL-SAIVFVLAILLLvLVTVYQPMMEMKRVGV 227 Streptococcus p...
WP_010905029 159 -N----QkygthITS-----KKLTTRPsDFYPNNYTSFI-----GLtnDN-LSLFIGISIVFFaIFLFVWLVGNNKKIAT 222 Lactococcus lactis
CAC03468     185 QRLAGISCFRLSFLGLKKRLTyiFITTIITLLTSSLILYIINlrrimYFYVIIFPTIFIVLVLLLIELIVGILVYLFLQR 264 Lactococcus lac...
WP_010896461 223 YSMHGFSLFKIWRRLIGNACG--VVFAVYLLFLPLLAFALFG-----WQPRYLFAAMVTGSWPFLLLLAISFLFVFYSSR 295 Bacillus halodu...
WP_014931904 205 KLFSGQTLLSIMGHSLSTDIKwlLLSALLSFLGGGVVLFSQGlfypiLLATYGFGISFYLLFLLAISILLMLLYLMSLNY 284 Streptococcus p...
WP_000870806 193 KYLNGFTLRKIIFENFSKKCTywVTLIITQILLTTSVLWILNyt--gNLDLFILRIVLLSCLFILTISVINLWTFLMLLN 270 Staphylococcus ...
WP_009930898 216 NRIWGNSELVTLMSLFNKTIIftLFSVLAILITFVSIVLANGla-tyLVEIVWKLLLFNVLLFIFILFPMYFFGLLRIKK 294 Listeria monocy...
WP_000724262 228 QKLLGFQDRAVLADVVKGNLYllLGGALVINLGVFFLLDYKP-------KDLFPMLWLSHFLLLQLYLFISWLTYLLIQK 300 Streptococcus p...
WP_010905029 223 YRLNGVSAHRIGLRLFLKEFF---IVTLLAYIFSSFLVFRG----------FNLQFSLQMFIMLLLVIIVSYISIVLVSS 289 Lactococcus lactis
CAC03468     265 QKINLVIKDMAPIRALMSFVFLLQLISLLCLIFSFSSISSSHKDLVLL-KKATNKWKSQ-DY---YSPSLLNGNTEKSKE 339 Lactococcus lac...
WP_010896461 296 SSLIESIKNNTKTKLFLIVSQVAKVVALVSVIVFLLQIADRLTIMEEV-RNSMTDWAFGkDYgefYPHSIGYDQEEMNQE 374 Bacillus halodu...
WP_014931904 285 KALVPVIKGRLPLKRLMILTLLCQLVAVFTVGYAVKTGLMSYQRLKEL-EISKQAWQDRaDY---YQISFGLGDRGKDTE 360 Streptococcus p...
WP_000870806 271 LNIANMIKGKQHFKTIRFINTVCKSILLVLIANVMIENTSVIKDLNKI-KETEKYWNVLdDY---YTIEFAPYHETKQSL 346 Staphylococcus ...
WP_009930898 295 IDQAKSDQRMQSSRQHLAINLVIKFVLLCLFIGTFIASYQSLQTLNTR-LANIDVWEATkDIfkvKVGVLPEGIQDDLKA 373 Listeria monocy...
WP_000724262 301 MTISSLLKGFSSFKFGLIFNYVMKIGTTILLTALLIGVGRSLEQENKE-LAYQQQWVSQgNYltlETFKLNDNLWQEELA 379 Streptococcus p...
WP_010905029 290 FSLANQINSKSFFKYSHYVLYAVKAFVFLITVSTTATLLYFVNAKLEItSKIGQEYAIL------YPEFSGYDGGQPLNL 363 Lactococcus lactis
CAC03468     340 N-VLR-------FLSEANQKEEVLIIADNFNKYPLQN------QYF---------PTSNGNENILYVTPNYLKKVGIKFN 396 Lactococcus lac...
WP_010896461 375 SgLWQtdislteSLYPVLNAAGALYIDAVLYEEEWLR------MAT---------EYSQEHIRSIRVNPNYLQAFPLVDE 439 Bacillus halodu...
WP_014931904 361 N-QSKwy----aFAKEAIEEEQALYVKDNLLHFANPQgkneqgETL---------DTYSPDANTLYVSPSYLDKEKVVAD 426 Streptococcus p...
WP_000870806 347 I-DNMvrs--eqLVKASEAENNAILFKPKGDSVDNDN------F-------------SPDEGNVILVNNQFWSIYYKQFQ 404 Staphylococcus ...
WP_009930898 374 DkELNdnl--saFYEEGTSKKEMFLMYSNNFQRSETN------TFFyetylkkgsEINSPEGNSVEIDFNYLKLNPIKSI 445 Listeria monocy...
WP_000724262 380 G-SGKstdyfyrFYQDLVEKTQAGYVQSSSLPVKNFV------Q-----------SEQIQQYQLTDTVDVYYANRNFLKS 441 Streptococcus p...
WP_010905029 364 S-CID-------LFVYAEEHDGLYISDSSIDIVENDS------------------------LNDLQINDNYLSKFAIYSQ 411 Lactococcus lactis
CAC03468     397 NTMKS---------DITILVPETEKSRKNKLSTLW-SQAFNS--------LNETSFSYNS--------SVYKSPSKDLFT 450 Lactococcus lac...
WP_010896461 440 NNKRIaiqe--eetNRVLLVPEQYKDQKEDIIAYFkEDYAYW--------ATMPEYQAESyshlqeqtFDIIWLASSQEV 509 Bacillus halodu...
WP_014931904 427 AETKQklah-lqkgEFILLLPEHLRSREAELKKVF-EERLSY--------YGKSGEEASApldyemkaHVSYLSMGEKRF 496 Streptococcus p...
WP_000870806 405 PDIPIknq----knNVEVIIPQKFHAMRNEINQAY-HSWFEF--------VQNKNNKENKl-------SIQFINKNDCRI 464 Staphylococcus ...
WP_009930898 446 KGQNVgkeaiisdkVLNIIVPNSKKGLEKDIKNTF-LDYFYFqkvevaniYNEALDLPAValskedlrVNIIYAENNQDY 524 Listeria monocy...
WP_000724262 442 KGFKLpnt----giKKVILMPASTKGEEDKNQLLG--KLIAF--------HSMKYEEQQKrtie-emdVEIAYYEGDWSF 506 Streptococcus p...
WP_010905029 412 DNQRVeinp--dtnSGIILVSEKYKSQLSKIKKYY----ASS--------DSLAFFKGST---------IKYYFIKDAQK 468 Lactococcus lactis
CAC03468     451 FRIFGWSAVDNQAFVQEPLIVVMSPKLFNINNKNIN----SDVLFSWFSREQILFSNNKTTADLIKKYRLENVLGSFSNG 526 Lactococcus lac...
WP_010896461 510 FSFNLYVFPNEGNLIVDPIIQVLTENNSYPMERDFFrgsvGNDPLKVKLLDQNTAKTYEHYLPLLRDLQLDDNAKHLVTV 589 Bacillus halodu...
WP_014931904 497 VYNNG-ENPVSTQYLTDPILVVFTPTSTGDSFI-------SLSSWSINAGKQLFIKGYESGLELLKKAGIYEQVSYLKEG 568 Streptococcus p...
WP_000870806 465 FSFDAR-DSRHLSFIEAPIIVNVQASDLSN-----------DFYYAMISQGGYLFKNYDALVKNIEKYHLDGEISGITNY 532 Staphylococcus ...
WP_009930898 525 FSYDSNTGDFRTGNITDPIAIVYTGNIDSSSIGA-------HVTSSVYFVDKSNGDAFNAILPLISNSNA-REITHVRSV 596 Listeria monocy...
WP_000724262 507 FPYSD----KRKENLSNPIISLVNDSDMMWDEKASL----STTGLN-NPIKIENTVQHQKEITELVEKLSDGNYLKFSSI 577 Streptococcus p...
WP_010905029 469 LDLLD----ENSTKISPDLVEVYTRKNFTDKGNVTF----QHNTVLKFKIRGTIEKTYQPLIPILKKNSALETHPSMIKI 540 Lactococcus lactis
CAC03468     527 NLSVKNRFVEIKSQQLFIVVTSSIALISSTFLFYLMNKIYLYQNRKKFAVARISGESLFTTHKTYLIQLFIIIIFAIGMI 606 Lactococcus lac...
WP_010896461 590 NEQAQKDISEIQRALTLDTILFVLTATIALFMIVQSSHLLFAQHKKRFLLRRLFGHSLFRAYRNVLFWTLATWVVILGIA 669 Bacillus halodu...
WP_014931904 569 RSVYLTRYNEVQTETATLILGAIVGIASSLLLFYSVNLLYFEQFRRDILIKRISGLRFFETHAQYMVSQFASFVFGASLF 648 Streptococcus p...
WP_000870806 533 KDSVMEMYHENNLKLTVLNFSQIIIAIILIIIILFDVKYYFEQHRKLLVIKKLYGYSTLRANYQYLLINNIVVIFIGILT 612 Staphylococcus ...
WP_009930898 597 YQEVSSEITTLKWQIYQQLIGTIILALCLCSFMVLLVLSYYRENLYKQLIYHVFGYSFWKSSKWFIISNLFVSVFSGILI 676 Listeria monocy...
WP_000724262 578 QAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRDIITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVL 657 Streptococcus p...
WP_010905029 541 DDISKTDNLSTVGNPYNYAVTNGLVILIFLSMILTTTVFYFETYKKKIAVKRLYGISFFVTYKTLFAIVLVQGSLYFAFA 620 Lactococcus lactis
CAC03468     607 FIWHL-N-PLTLIIPPILGGLQLILLTRQIKNNKTFNISVLKG 647 Lactococcus lactis subsp. lactis
WP_010896461 670 LYRHSgTqYLAIVVLVLFLTEVVVTSVVLMRLEQKNKVSVLKG 712 Bacillus halodurans
WP_014931904 649 ILSSR-DlVIGLFTLLVFLASAVLTLYRQAQKESRVSMTIMKG 690 Streptococcus pneumoniae
WP_000870806 613 NVILH-ShYIMMLFATILVVQILLQICSLYYHGRRFNEVIKEF 654 Staphylococcus aureus
WP_009930898 677 FILSK-EpVALYFSVVILIIELCAIYFIKEKAIYKDFKAILKG 718 Listeria monocytogenes
WP_000724262 658 IFFAH-AfLPLLLFAGFTCLDILFVLGLASRMEKRSLVELLKG 699 Streptococcus pneumoniae
WP_010905029 621 LSQRD-VnITLEGLGIYFVLEILIIILILLKLQKGLFLNVLKG 662 Lactococcus lactis
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