Conserved Protein Domain Family
DUF6056

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pfam19528: DUF6056 
Family of unknown function (DUF6056)
This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 448 and 528 amino acids in length. There is a conserved NYL sequence motif.
Statistics
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PSSM-Id: 437360
Aligned: 62 rows
Threshold Bit Score: 213.673
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_021770419              2 TRHKGL----QTAVVALSIFALLY--ALNRMMPL-HRDDYDYSMVWMT-------ARHITSFGDVLESVCRHYLLHGGRA 67  Mits...
SFO69528                  1 MRNIKKscdnTYVYYMTLFFLAML--WLQLFDSFtLSDDLAYHFVWQKdeg--qaLQVIRNFNDLINSQLVHYQILNGRL 76 
WP_006254804              4 GS--------YSLVLLLMLAALVS--YFSYVSPW-VGDDIEYAYFSAIkdt-ngtNLPIHTLQDIFVSQYNHYQSTNGRT 71  Allo...
EOL42979                  1 MFMKKK----NFLFTVGICFLFIF--VLNYLTTY-ATDDFSYRFVFDHyglptdnPEKITGFFSIVRSMWRHYFAMNGRW 73 
WP_057905531              1 MRKKGYqtlrILGFVAVLGVVYLLfkQLNDYTGY-SADDYLYHFFFTGewp-arhLRGIHNLFDLIQSIQNHTRINNGRF 78  Loig...
WP_054733976              1 MKHTAKvligIIGLIVISVGVFLVmkLLNDLSGY-SADDYLYHFFFTGewp-akhLRGIHNGLDLIQSVQNHTRLFNGRF 78  Secu...
KRN94761                 32 NVFKIAsttlASLLVLGIVFIYIL--NINKFAGL-TGDDFLYHFVYTGewpakngARTYQNLWDWVQAIYIHMTQWNARL 108
PRJNA404006:CMV25_08730  11 NILLVV----LSALVLCINFIFIL--NLNRFSGY-TGDDFLYHFVYTGawp-sqnLREYHNLWDWISAVHTHMTIWNARM 82 
EKF50733                 19 NVLRTI----ITLAILSLTFIFIL--NLNHYTGY-TGDDFLYHFIYTGawp-sehLSEYHNLSDYISAVYTHMTLWNARM 90 
KRM79118                 27 NVLLLG----FSGLVMGIIYLFIL--NLNQFTGY-TGDDFLYHFVYTGawp-sryLNEYHNLWDFVSAVYTHMSIWNARM 98 
WP_021770419             68 VTVFFLDTFLL-LG-KSVFDFANALVFLALVVLMAMHARrGAAFWREPGIFAAAGLLTWLCLPHFGEVAVWKSGSTVYLW 145 Mits...
SFO69528                 77 VVHTIAQFFLS-FTpPFIYQFLNALLFVLLLYLSVRIMH---LSKFKTFASILMCFLLFVVFSGFRTAILWSMGSFNYLW 152
WP_006254804             72 VAHCFVQFFCGiGG-QIAFSICNGLMYILLVVLICRLIH--WDWKKPRSVFVTLLLVLFTFN-----TGFTPSCQIGYIW 143 Allo...
EOL42979                 74 LAHSFVQFFMS-QN-KLLFDFFNSIFFLLLGWLLNYLASlLLETENDLSNLSFIYPLLWLSLPEFGKSVLWLSGACNYLW 151
WP_057905531             79 VAHTGVQLFMQ-WP-KSVYNIANSIVFLLVGILINLHLF-GRLSRLRVGYLMLTFMLMWVCLPDYGTSILWLSGGFNYLW 155 Loig...
WP_054733976             79 VAHTGVMTMMQ-FP-KAVFNVANALVFVVVGWLMNVHVF--GKQRIKVGFLALTFALMWFGLPDYGTTILWLSGGFNYLW 154 Secu...
KRN94761                109 TSIIFEIAAMQ-IP-KSLFNIINAIVYLILGLEINILAS-GKKFIFQPIKLLITYLLMWFFLSGFGSTVLWVSGAANYLW 185
PRJNA404006:CMV25_08730  83 TSIIFEIFAMQ-IP-KGLFNIINSASYVLLGFLFNVLVS-GKQAFLKPVRLALTFLLMWFFIPGMGSTVLWVSGAANYLW 159
EKF50733                 91 TSIIFEILAMQ-MP-KSIFNILNASIYVLVGLLLNVVVS-GKKAFLKFLHLALTFLLMWFFIPGMGSTVLWVSGAANYLW 167
KRM79118                 99 TSIIFEILAMQ-IP-KTLFNILNSLIFVLVGLLLNILVS-GRKAFLKPIHLLLTFLLMWFFLPGIGTTVLWVSGAANYLW 175
WP_021770419            146 SAVPVLLFLLPYNvhlrvigtgKEGTLSHRRIFAVPLFLL---GIVAGWSVENLAV----TTVVVSAGISFy-AYRKGAM 217 Mits...
SFO69528                153 VIVYTLIFLLYLRk--------LYFTDNNRLFFHIIVSPL---SIFIGCSHEGLSL----PISITFFTFIIa-KRKQI-- 214
WP_006254804            144 MFCTALGTLYIFQ-----------RQPQLSFFSAILVFLF---SILAGWGQESLNFglcmSFFVFFL------PHFKQNK 203 Allo...
EOL42979                152 MSLVYLSYLLVFK--------------KINKYRWYNVFLLiglGILSGATGENSGA----ATVIVVFLLWLf-TEHQPKK 212
WP_057905531            156 VALIYLSFLLPYR---------FNYQAQHPRIMFVGMLLL---GFLAGGTNENTAP----LTLFIALGFTIc-DWKQG-- 216 Loig...
WP_054733976            155 MAMIYLLFLLPYR---------FNYQAHHPMLMAIGMSVL---GFLAGATNENTAP----LTLFIAFAFTLf-DWQKS-- 215 Secu...
KRN94761                186 PTTIILAFFIPYRfn-----yrIKVYYSIAAWIAL---IF---GILVGMSNEVGGA----TAIVIVGMFTFfdRSSGDFN 250
PRJNA404006:CMV25_08730 160 PSLVIILFFLPFRfd-----iaVS-----NNWVSLGLFIL---GLLTGLTNEVGGS----TAVLLAFLFMIfnYRRWPSE 222
EKF50733                168 ATVIILLFLLPYRfn-----vsTK-----RGWEEFYLPVL---GLLAGLTNEVGGA----TTVLLALIFTVynLKKSGSG 230
KRM79118                176 PTVVIICFFLPFRfd-----mgSK-----NDWIGFGLFVL---GLFAGLTNEVGGA----TAVLVALLFTVynYRKSHGA 238
WP_021770419            218 MP-WMPAGALGALLGLIGLIGAPGNFVRYDAQGSGKGilthignqfagngemvlyilpailllilawrlyrlrmageevg 296 Mits...
SFO69528                215 LHqAIFLYICWYIIGTILCVISPGIWNRVDGGIPMYNrllsgli------------------------------------ 258
WP_006254804            204 AArWLV--LIGFGLGTLMICLSPGAWTRAAQSHQLLNvsllnla------------------------------------ 245 Allo...
EOL42979                213 LMyWKLISVMSSAISSIILIKSPGALKIESNLSILTSnfft--------------------------------------- 253
WP_057905531            217 QLaWKWAGGIAGAESWIVLVISGSQQVAKRGSQFQIQklltat------------------------------------- 259 Loig...
WP_054733976            216 QLaWKWCGGLFGALGFYIMVKSGSQQIAVRGKQFEIGkllqna------------------------------------- 258 Secu...
KRN94761                251 DLwWKIIGVLSNAIAFVVMLKLSSKSAETQNYGVHDRfavhvvkvv---------------------------------- 296
PRJNA404006:CMV25_08730 223 HIlTQASGVFGAGIGFCIQLTLSSGSAETQNYGKSAGllqrlsdvf---------------------------------- 268
EKF50733                231 NTvAQILGTVAVAFGFGTQVILSSGSAETQNYGASTGlgqrfldil---------------------------------- 276
KRM79118                239 GVlTQAAGVLGALVGFITQLSLSSGSAETQNYGQATGfiqhlsavv---------------------------------- 284
WP_021770419            297 tpserkhgigrFLLAAFVAFLVVsyfnggfvawalrdflvghvlvplgldkpktidhfnnimhgfeemaiywlaiflfys 376 Mits...
SFO69528                259 ----nlisnvrITWLLVITLLILfkrn----------------------------------------------------- 281
WP_006254804            246 -----hysralYLYLFYALYLLLfr------------------------------------------------------- 265 Allo...
EOL42979                254 -------likfSLLLIVPILLSIyfly----------------------------------------------------- 273
WP_057905531            260 -----wqysglLLLLVLGVAFYLywqhhgy-------------------------------------------------- 284 Loig...
WP_054733976            259 -----ghysgwLLALAFGLLIYLywqhhty-------------------------------------------------- 283 Secu...
KRN94761                297 ---egtwtysgPLLIMTLFLAVGliivqrkfwk----------------------------------------------- 326
PRJNA404006:CMV25_08730 269 ----lgtiqhsgLLILAILLLGGllylrr--------------------------------------------------- 293
EKF50733                277 ----sgtahysgFLLLPIVVFGVllyfnr--------------------------------------------------- 301
KRM79118                285 ----fgtihysgFLLLAIFVLILllflrr--------------------------------------------------- 309
WP_021770419            377 wgkerlglqkariralapvprcavlARFP----VAKYASRLIALALFNNFVM-----IAAPTFPARATFSSTVMILIAVL 447 Mits...
SFO69528                282 ----------------------kleFKAKlyqyRYVYLCLFFSLGIVTVCGT----------NLERVAFFTDFMAMLLLV 329
WP_006254804            266 ------------------------rAKIG----QFFHTNAFYLIAIFTLLCFnliigISGP----RQLLGIELLSILGLL 313 Allo...
EOL42979                274 ----------------------klsKANVfescHRVFLFIFVTGALASFFSL-----VFAEHSTPRNLFSVAIYLNLMLV 326
WP_057905531            285 -------------------graftwRDQR----LYLAGCLYGVGAILGIISL-----IVSPQILSRVFFGPSLYLITALL 336 Loig...
WP_054733976            284 -------------------ghrlvwRQQR----TFVAAWLYGVGAVLGIVAL-----VVSPQILSRVFFGPNLYLIIAIL 335 Secu...
KRN94761                327 ----------------rifsevarsELER----TMLSGMIFLLGGLAGVGAM-----IFSPVLFPRLWFAVNVLLIIALV 381
PRJNA404006:CMV25_08730 294 --------------------hqwteKVKV----IVTAGLIFFVSGLAGSAAI-----VASPITPARLWFASNVLLIAALL 344
EKF50733                302 --------------------dqlqeKACN----LWHGGIIFLISGLAGCFAI-----LASPIIPARLWVASNILFIIALL 352
KRM79118                310 --------------------qqmdnTVES----LSVMGLFFSGAGLLGCGAI-----MASPITPARLWFASNILFIIALL 360
WP_021770419            448 AVLRDPV-------VAAPIAARGRKLLVtaggALGTFTmaaalvitHEMDEANAARLAIVERAAASGNPIacmepirrk- 519 Mits...
SFO69528                330 ELWSVL--------LSLKWQRYIIICCS----ILMILFyi----paVAVREENKRNCDYMKQQMSEPEREliavrqp--- 390
WP_006254804            314 QSQQSFE-------TKRAYNTAFIMLLT----FFTTLIilkrmsftLQTRTAFDQTMAACR-KAPSGSTVih-------- 373 Allo...
EOL42979                327 YLLYLMKd-----yFEKKRPFMINTVLT----LVSLVIyipvtsqlAENYLEYEQEIAVIEQTKREHKKLavvqgitwpd 397
WP_057905531            337 LLLADYArlrrqawLPTLIPYIVAAVLA----FMSIPTyvaavnsnFQSYQYWRTGDVRCRQAKQAGQTSasvpgqppv- 411 Loig...
WP_054733976            336 LALKDHAllrqgtwLVRLLPISAALILG----FLAIPGyqaavrsnLQSYRTWATGDAICREDAKRGIAHakvpgmqpv- 410 Secu...
KRN94761                382 NFFGAYEmysekslLSRIILMGSALGLL----YLMIPSyqthmnnlKKSYNVFYTHEKLTAQARKNGEKTvylpgmpvt- 456
PRJNA404006:CMV25_08730 345 LLIEAWQelrlqqvKTAVPLMIGVFVLT----FVAIPSyaynlkdiQNSYQYFYTAQSIAQKAKKDKEISahvpgmpit- 419
EKF50733                353 MMFEAWQelraqssWTNVPLCIAILCLT----FVSLPSydynlkdiKNSYEYFYTAQTIAQKAKEEGKTSarvpgipmt- 427
KRM79118                361 MLIEAWQelrlqsfKTMFPLIIAVLGVG----FVVIPSytynlkdiQNSYQYFYSAQAIARDAKNKEQTTarvpgmpit- 435
WP_021770419            520 ----nralrhvfFVDF-------------------DNGVTKdGLCKY---FGIANIKVTGA 554 Mitsuokella sp. oral ta...
SFO69528                391 ------ikgenhIMDFfreryvnpsaefgfyccymGFNAQDiNMRQAatlYGKKKMIFLPE 445
WP_006254804            374 ----------yfGSDA-------------------KAWPGDhFLRTM-----EKKIKIETG 400 Alloprevotella tannerae
EOL42979                398 nqlvglynpyykMQYLss---------------dsHAWLNE-WMSKF---YTVKGIRLEKK 439
WP_057905531            412 ---fndhnmylsSTYVagg-------------qpdKQWFNV-WMARY---YGLKTVRLNNR 452 Loigolactobacillus bife...
WP_054733976            411 ---ytdrnqyvsSTYVsng-------------npnKQWFNV-WMARY---YGVKSVAVDNT 451 Secundilactobacillus si...
KRN94761                457 ---tdlynpyngTPYImpg-------------nskKLWSNV-WMAEF---WHVDRIILDND 497
PRJNA404006:CMV25_08730 420 ---tnpynpyagTPYLvasd------------kpeKEWLNV-WLAKY---YGLNKVYLDNT 461
EKF50733                428 ---sngynayfgTPYLvase------------hpeKEWSNT-WFAKY---YGLEKVYLDDT 469
KRM79118                436 ---tnpynaydgTPYLvasd------------hpqKEWANT-WFAKY---YGLTRVYLDNS 477
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