4LHC


Conserved Protein Domain Family
gcvP

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TIGR00461: gcvP 
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glycine dehydrogenase (decarboxylating)
This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]
Statistics
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PSSM-Id: 273089
Aligned: 4 rows
Threshold Bit Score: 1735.55
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4LHC_A         36 RHLGPGETEQRQMLQTLGFDTLGDLIDQAVPPAIRFPRSLQLPASQS---EYGAIAQLKSIASKNQ-VFRSYIGMGYYDT 111  Synechocystis...
WP_010873139   36 RHLGPGETEQRQMLQTLGFDTLGDLIDQAVPPAIRFPRSLQLPASQS---EYGAIAQLKSIASKNQ-VFRSYIGMGYYDT 111  Synechocystis...
CDW60611      130 RHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPAT---EYAALAELKAIASRNK-RFTSYIGMGYTAV 205  human whipworm
P49095         70 RHLGPSPSDVKKMLKTMGYSDLNAFIEELVPPNILKRRPLKLEAPSKgfcEQEMLQHLEKIANKNHyKVKNFIGKGYYGT 149  Saccharomyces...
4LHC_A        112 ITPPVIQRNILENPGWYTAYTPYQAEIAQGRLEALLNFQTMVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSK-ANA 190  Synechocystis...
WP_010873139  112 ITPPVIQRNILENPGWYTAYTPYQAEIAQGRLEALLNFQTMVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSK-ANA 190  Synechocystis...
CDW60611      206 QLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKnANR 285  human whipworm
P49095        150 ILPPVIQRNLLESPEWYTSYTPYQPEISQGRLEALLNFQTVVSDLTGLPVANASLLDEGTAAGEAMLLSFNISRKK-KLK 228  Saccharomyces...
4LHC_A        191 FFVAQDCHPQTIEVIKTRANPLGIEVIVGDHHTFSFSTSIF------GALLQYPATDGAVY---DYRSFIDKAHQHQALV 261  Synechocystis...
WP_010873139  191 FFVAQDCHPQTIEVIKTRANPLGIEVIVGDHHTFSFSTSIF------GALLQYPATDGAVY---DYRSFIDKAHQHQALV 261  Synechocystis...
CDW60611      286 FFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVF------GVLLQQVGTTGEIH---DYTALISELKSRKIVV 356  human whipworm
P49095        229 YVIDKKLHQQTKSVLHTRAKPFNIEIIEVDCSDIKKAVDVLknpdvsGCLVQYPATDGSILppdSMKQLSDALHSHKSLL 308  Saccharomyces...
4LHC_A        262 TLAADPLSLTLLTPPGELGADIAVGSTQRFGIPLGYGGPHAAYFATKAEYQRKMPGRIVGVSKDAHGNPALRLALQTREQ 341  Synechocystis...
WP_010873139  262 TLAADPLSLTLLTPPGELGADIAVGSTQRFGIPLGYGGPHAAYFATKAEYQRKMPGRIVGVSKDAHGNPALRLALQTREQ 341  Synechocystis...
CDW60611      357 SVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQ 436  human whipworm
P49095        309 SVASDLMALTLLKPPAHYGADIVLGSSQRFGVPMGYGGPHAAFFAVIDKLNRKIPGRIVGISKDRLGKTALRLALQTREQ 388  Saccharomyces...
4LHC_A        342 HIRRDKATSNICTAQVLLAVMASMYGVYHGSTGLKNIALRIHQLTVLLAIGLKRL--NYSLNNDYFFDTLRVGVGEQSAP 419  Synechocystis...
WP_010873139  342 HIRRDKATSNICTAQVLLAVMASMYGVYHGSTGLKNIALRIHQLTVLLAIGLKRL--NYSLNNDYFFDTLRVGVGEQSAP 419  Synechocystis...
CDW60611      437 HIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQK--GLKLRHAHYFDTLCVEVADKAG- 513  human whipworm
P49095        389 HIKRDKATSNICTAQALLANVASSYCVYHGPKGLQNISRRIFSLTSILANAIENDscPHELINKTWFDTLTIKLGNGISS 468  Saccharomyces...
4LHC_A        420 A--ILKAAEGRGINLRPLVPGEVGISLDETVTVQDLLDLWQVFAGKDnlpfTPEELWSEVKT---SFPADLTRQSLYLQD 494  Synechocystis...
WP_010873139  420 A--ILKAAEGRGINLRPLVPGEVGISLDETVTVQDLLDLWQVFAGKDnlpfTPEELWSEVKT---SFPADLTRQSLYLQD 494  Synechocystis...
CDW60611      514 ---VLTRAEAAEINLRSDILNAVGITLDETTTRENVMQLFNVLLG-DnhglDIDTLDKDVAHdsrSIQPAMLRDDEILTH 589  human whipworm
P49095        469 EqlLDKALKEFNINLFAVDTTTISLALDETTTKADVENLLKVFDIEN----SSQFLSEDYSN---SFPREFQRTDEILRN 541  Saccharomyces...
4LHC_A        495 AVFNQYHSETELLRYLHQLESKDLALNTSMIPLGSCTMKLNATAEMMPVTWPEFGKIHPFAPAGQTEGYQILFAQLEAWL 574  Synechocystis...
WP_010873139  495 AVFNQYHSETELLRYLHQLESKDLALNTSMIPLGSCTMKLNATAEMMPVTWPEFGKIHPFAPAGQTEGYQILFAQLEAWL 574  Synechocystis...
CDW60611      590 PVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWL 669  human whipworm
P49095        542 EVFHMHHSETAMLRYLHRLQSRDLSLANSMIPLGSCTMKLNSTVEMMPITWPQFSNIHPFQPSNQVQGYKELITSLEKDL 621  Saccharomyces...
4LHC_A        575 GEITGFDAISLQPNAGSQGEYAGLQVIRQYHLSRGEEQRNICLIPESAHGTNPASAVMCGMQVVPVKCDGEGNIDVEDLT 654  Synechocystis...
WP_010873139  575 GEITGFDAISLQPNAGSQGEYAGLQVIRQYHLSRGEEQRNICLIPESAHGTNPASAVMCGMQVVPVKCDGEGNIDVEDLT 654  Synechocystis...
CDW60611      670 VKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLTDLR 749  human whipworm
P49095        622 CSITGFDGISLQPNSGAQGEYTGLRVIRSYLESKGENHRNVCLIPVSAHGTNPASAAMAGLKVVPVNCLQDGSLDLVDLK 701  Saccharomyces...
4LHC_A        655 SKAEKYGDRLAALMVTYPSTHGVFEATIGTICDIVHRFGGEVYMDGANMNAQVGLCRPADFGADVCHLNLHXTFCIPHGG 734  Synechocystis...
WP_010873139  655 SKAEKYGDRLAALMVTYPSTHGVFEATIGTICDIVHRFGGEVYMDGANMNAQVGLCRPADFGADVCHLNLHKTFCIPHGG 734  Synechocystis...
CDW60611      750 AKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGG 829  human whipworm
P49095        702 NKAEQHSKELAAVMITYPSTYGLFEPGIQHAIDIVHSFGGQVYLDGANMNAQVGLTSPGDLGADVCHLNLHKTFSIPHGG 781  Saccharomyces...
4LHC_A        735 GGPGMGPIGVKSHLQAFLPRTSLNSTAELQAEDQSIGMISAAPYGSASILVISWMYIAMMGPQGLTKATEVAILSANYMA 814  Synechocystis...
WP_010873139  735 GGPGMGPIGVKSHLQAFLPRTSLNSTAELQAEDQSIGMISAAPYGSASILVISWMYIAMMGPQGLTKATEVAILSANYMA 814  Synechocystis...
CDW60611      830 GGPGMGPIGVKAHLAPFVPGH---SVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIA 906  human whipworm
P49095        782 GGPAGAPICVKSHLIPHLPKHDVVDMITGIGGSKSIDSVSSAPYGNALVLPISYAYIKMMGNEGLPFSSVIAMLNSNYMM 861  Saccharomyces...
4LHC_A        815 KRLENYYPILFR---GNNELVAHECILDLRPLKKQaAIEVEDVAKRLMDFGFHAPTVSWPVLGTMMVEPTESESLGELDR 891  Synechocystis...
WP_010873139  815 KRLENYYPILFR---GNNELVAHECILDLRPLKKQaAIEVEDVAKRLMDFGFHAPTVSWPVLGTMMVEPTESESLGELDR 891  Synechocystis...
CDW60611      907 SRLQDAFPVLYT---GRDGRVAHECILDIRPLKEEtGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDR 983  human whipworm
P49095        862 TRLKDHYKILFVnemSTLKHCAHEFIVDLREYKAK-GVEAIDVAKRLQDYGFHAPTLAFPVPGTLMIEPTESENLEELDR 940  Saccharomyces...
4LHC_A        892 FCDAMIAIYQEAQAITHGEIDPAdnPLKNAPHTAQSLICGEWNHP--YSQEEAAYPAPWTKQFKFWPAVGRINNTYGDRH 969  Synechocystis...
WP_010873139  892 FCDAMIAIYQEAQAITHGEIDPAdnPLKNAPHTAQSLICGEWNHP--YSQEEAAYPAPWTKQFKFWPAVGRINNTYGDRH 969  Synechocystis...
CDW60611      984 FIDAMLAIRAEIDQVKAGVWPLEdnPLVNAPH-IQSELVAEWAHP--YSREVAVFPAGVAD--KYWPTVKRLDDVYGDRN 1058 human whipworm
P49095        941 FCDAMISIKEEINALVAGQPKGQ--ILKNAPHSLEDLITSSNWDTrgYTREEAAYPLPFLRYNKFWPTVARLDDTYGDMN 1018 Saccharomyces...
4LHC_A        970 LVCSC 974  Synechocystis sp. PCC 6803 substr. Kazusa
WP_010873139  970 LVCSC 974  Synechocystis sp. PCC 6803
CDW60611     1059 LFCSC 1063 human whipworm
P49095       1019 LICTC 1023 Saccharomyces cerevisiae S288c
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