Conserved Protein Domain Family
metL

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PRK09466: metL 
bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional
Statistics
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PSSM-Id: 236530
Aligned: 136 rows
Threshold Bit Score: 1078.41
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
290477220  11 FGR------QLHKFGGSSLADVKCYQRVAEIMANYSQPGDLMVVSAAGSTTNQLIDWLK----------LSQSDRISAHQ 74 
294142510   1 MARc-----HLHKFGGSSLADADCYRRVAHILLTHGNSDDLVVVSAAGKSTNFLYKLLE----------LKDTGLLWQEE 65 
170724988   1 MARg-----HLHKFGGSSLADADCYRRVAHILLTHGNSDDLVVVSAAGKSTNFLYKLLA----------LKDSSQLWQEE 65 
157960390   1 MARc-----HLHKFGGSSLADADCYRRVAHILLTHGHSDDLVVVSAAGKSTNFLYKLLE----------LSTTKQLWQEE 65 
157377172   1 MARc-----HLHKFGGSSLADADCYRRVAHILLTHGNSDDLVVVSAAGKSTNFLYKLLE----------LKDTAQLWQEE 65 
167622563   1 MARc-----HLHKFGGSSLADADCYRRVAHILLTHGHSDDLVVVSAAGKSTNFLYNLLE----------LSSCKQLWQEE 65 
127511455   1 MTRc-----HLHKFGGSSLADADCYRRVAHILLTHGHSDDLIVVSAAGKSTNFLYRLLE----------LCDTDQLWQEE 65 
212637260   1 MARc-----HLHKFGGSSLADADCYRRVAHILLTHGHSDDLVVVSAAGKSTNFLYRLLE----------LSTTKQLWQEE 65 
71281091   18 ENKlakhaiQVHKFGGSSLATPKCIKRALEIIRENCQLNDIVVVSANGKTTDRLFALYSlvertiaedtIQKSDELT--Q 95 
56461566   16 DSV------QVHKFGGSSLADAFCYRRVARIVTEYAGASDLVVVSAAGDTTNRILAIIN----------AKAQPGDTASI 79 
290477220  75 VqQSLRRYQQELIRGLLPEVIAEELVAHFISDLEKLSVLLD-KPITDITYAEVVGHGEIWSARLMAAVLEHKGISSAWLD 153
294142510  66 L-QVLISFQQNLIEQLLSNEQARSLRERLSIDKYQLISLFSlEVLNEYKRSEVVSFGERWSARLLAALLRESGVAASDVD 144
170724988  66 L-QVLISFQQNLIEQLLSNEQARSLRERLSIDKYQLISLFSlDSLNEYKRSEVVSFGERWSARLLAALLRESGVAASDID 144
157960390  66 L-QTLISFQQNLIEQLLSNEQARSLRERLSNDKAQLISLLSiESINEYQSNQVVSFGERWSARLLAALLRESGVAASDVD 144
157377172  66 L-QVLISFQQNLIEQLLSNEQATSLRERLSIDKYQLISLFSqDELKEYERSEVVSFGERWSARLLAALLRESGVAASDVD 144
167622563  66 L-QMLISFQQNLIEQLLSNEQARALRERLSNDKAQLISLLSlESISDYQSNQVVSFGERWSARLLAALLRESGVAASDVD 144
127511455  66 L-QVLVSYQQNLIEQLLSNEQARSLRERLATDKSQLTSLLSlDELNDYQRNQVVSFGERWSSCLLAALLRESGVAATDVD 144
212637260  66 L-QILISFQQKLIEQLLSNEQARSLRERLSNDKAQLISLLSlTAINDYQSSQVVSFGERWSSRLLAALLRESGVAASDVD 144
71281091   96 AiDELAKEQAQLITELLNANNTKQLLLRLHKDIEQLTTWLT-ADIVQH-HNDVLALGEVWSARLLSALLNEQVCPSNSID 173
56461566   80 LlDQLESFQQGLITELLSGNLQQQLLQQSQQDFARWRRWLA-CDETISHNAELLSYGELWSARLLSALLQKQGTRADHID 158
290477220 154 ARQFLRAERAAQPQVDVNLSQPLLSQLLIQNPSKRLVVTGFISRNQKGETVLLGRNGSDYSATQVGALAGAKKVTIWSDV 233
294142510 145 ARSLLLADEGAVPLIRLDESRQRVQNSINAHPNERLIITGFICANSRGETLLLGRNGSDYSATLIASLADIERVTIWTDV 224
170724988 145 ARSLLIADEGAIPQIRVDESRARVLKRVDDSPNERLIITGFICANSQGETLLLGRNGSDYSATLIASLANIGRVTIWTDV 224
157960390 145 ARTLLIADEAAVPQIRLQDSRQRVHSMTETHPNERLIITGFICANERGDTLLLGRNGSDFSATLIASLADIERVTIWTDV 224
157377172 145 ARTLLLADEGGVPQIMLVESRQRVRQVLNDHPNERLIITGFICANSRGETLLLGRNGSDYSATLIASLAAIERVTIWTDV 224
167622563 145 ARTLLIADEAAVPQIRLQESRQRVHAMTETYPNERLIITGFICANNRGETLLLGRNGSDFSATLIASLADIERVTIWTDV 224
127511455 145 ARTLLVADEGAVPQIRLGESRQKVQALLEAHPQERLVITGFICANEQGDTLLLGRNGSDFSATLLASLADIERVTIWTDV 224
212637260 145 ARTLLIADEGAVPQIRLQQSRQRVQKLIAEHPNERLIITGFICANDKGDTLLLGRNGSDFSATLIASLADIERVTIWTDV 224
71281091  174 SRDFLVIDNEQSCVVDTALSAAQLRQ--RRQFGKLAVITGYISKDSRGKSCTLGRNGSDYSATIIASLVAAGNVTLWTDV 251
56461566  159 ARDFLLAADAPEPVIQVEHSREKLLQRVAPHSGTRFIVTGFIARGLHGESLTLGRNGSDYSATLVGSLLDTRQVTIWKDV 238
290477220 234 AGVYSADPRKVKDACLLPLLRLDEASELARLAAPVLHTRTL----QPVSVSDIDLQLRCSYQPEQGSTRIERvLATGTGA 309
294142510 225 EGVFNADPNKISDAKLLKSLSLDEANRLAHLGSPVLHNRSL----QPLFDTQVSLAVRSSYASHTDFTLIAP-KSSSASA 299
170724988 225 EGVFNADPNKINDAKLLKSLSLDEANRLAHLGSPVLHNRSL----QPLFDTDVSLAVRSSYASHTDFTLIAP-KSSSASA 299
157960390 225 EGVFNADPNKINDAKLLSSLSLAEANRLAHLGSPVLHNRTL----QPLFDTQVSLAVRSSYASHTDFTLIAP-KSSSASA 299
157377172 225 EGVFNADPNKINDAKLLKSLSLDEANRLAHLGSPVLHNRSL----QPLFDTEVSLAVRSSYASHTDFTLIAP-RSSSASA 299
167622563 225 EGVFNADPNKINDAKLLSSLSLAEANRLAHLGSPVLHNRTL----QPLFDTQVSLAVRSSYASHTDFTLIAP-KSSSASA 299
127511455 225 EGVFNADPNRINDAKLLKSMSLTEANRLAHLGSPVLHNRTL----QPLFDTEVSLAVRSSYAPHTDFTLIAP-KSSSASA 299
212637260 225 EGVFNADPNKINDAKLLSSLSLDEANRLAHLGSPVLHNRTL----QPLFDTQVSLAVRSSYASHTDFTLIAP-KSSSASA 299
71281091  252 DGIYSADPRVVPSARKLHRLPNGVAKELGRLGNPVLHAKTLlpliNPLSEHHTHLHVASSFDAQVIGTEIGKfGQIAKQE 331
56461566  239 AGVYSADPRKVERVVSLPTLDWTEAEELARLGSPVLHPRTF----QPVDRQRMVISVRSSLKVENQQTRIGQfQNTQPRG 314
290477220 310 KIVTSHDDVCLIELHISsahdfkqiykDIDSLLKRAQIRPLATg-LHADCNLIQLCYTSEVVNSALDVLQDASLP-GKLS 387
294142510 300 PVVTNLASVSLFNFRIKnk------iaNLAELLEQAELLPLAHw-KLAHDR-VELAFTHENHKQVEAILQSEALGvSDLS 371
170724988 300 PVVTNLSSVSLFNFRLTag------lqSVIELLAEAGLIPLAHw-KLAQNR-VELAFTNENSKQVQSILELDAEP-LGIA 370
157960390 300 PVVTNLSSVALFNLELTte------lkQLIELLEETGLSPLAYweLGQGRAEITVTLENQKQVLALLDINRDALGvSDIK 373
157377172 300 PVVTNLASVSLFNFRITte------isNLAELLAASGLNPLAH--WQLAHGRVELAFTHENQQQVRAILESEVPGvSDLL 371
167622563 300 PVVTNLSSVALFNLELKsd------fkQLIELLEETGLSPLAYweLGQDRVELTVTLENHKQVLALLDVNRDALGvSDIK 373
127511455 300 PVVTSLSSVSLFSLTISve------lpQLLACFAQAGLTPLAYwsLAHGRAELAFTHENQKQAQAIFEAKRSELGiDELQ 373
212637260 300 PVVTNLNSVSLFNIQLNgv------lsDLLSLLTDSGLYPLAHwsLAQKRIELTVTLENQKQVQALLDANSDALGiTDLQ 373
71281091  332 LSVTYLNDLLLAQSvs---------fiGEAATRAKAEFSPICI-----DDQKGFMVITQGQQKALSDWLASHDVE-ITFK 396
56461566  315 KVFTSLSEVVLFKVElh--------dkALVKRLDELELEPLVSw-TEPENHQQYLVFHQNHLDYLTGWLDSLGAG-DAIT 384
290477220 388 ---LREGLALVALVGAgvckNPLHSHRFYQQLKDQPIEFIWhaEEGISLVAVLRLSQTSHLIQGLHQSLFRAEKRIGLVL 464
294142510 372 ---SREDLGLVALVSA----DASLYRRRFARLLSRDARPLF--KDGLSLVTLVPSAQVNLLTQKVHRRCAGPRKRIGVLL 442
170724988 371 dirVREDLGLVALVSA----DSNLYRRGFARLLSRDARPLF--NDGLSLVTLVPFGQVNLLTQKVHRRCAGPRKRIGVLL 444
157960390 374 ---ITEDLGLVALVSA----DASLYRRGFARLLSRNARPLF--NDGMSLVTLVPQGQVNLLTQKVHRRCAGPRKRIGVLL 444
157377172 372 ---LRENLGLVALVSA----DAELYRRGFARLLSRDARPLF--NDGLSLVTLVPCANVNLLTQKVHRRCAGPRKRIGVLL 442
167622563 374 ---ITEDLGLVALVSA----DASLYRRGFARLLSRNARPLF--NDGMSLVTLVPQGQVNLLTQKVHRRCAGPRKRIGVLL 444
127511455 374 ---LRDDLGLVALVSAda---sLYRRGFSRLLSREAHPLc---NDGLSLVTLVPKAQVNLLTQKVHRRCAGPRKRIGVLL 444
212637260 374 ---IREDLGLVALVSA----DADLYRRGFARLLSRNARPLF--NDGMSLVTLVPQTQVNLLTQKVHRRCAGPRKRIGVLL 444
71281091  397 ------PVAIIATVGHrvaeRGDIRARFKRSLKAAKPLNLVgsDNNHSVIAILPEPCSIELLNTVHHEMTKDARHIGLVV 470
56461566  385 ---QIRGYSMLAIVGNriqeTDQFST-FKLQLSEQKVRRFAltQNGDSAVAILEQKLDNRLLNRLHSQLFNYRRSLGVLV 460
290477220 465 FGKGNIGSRWLELFAREQKNISARSGFEFILAGIVDSRRSLLNYQGLDASRALAFFGDEATQHEDDALFLWMRAHPYDDL 544
294142510 443 LGTGNIGEAWVDLFNRVRGSLNKELEANVELIGLLSSKKALLKEQGIDLDAWKQEFEQQATPWLYDHLFEQLQALECDEL 522
170724988 445 LGVGNIGEAWVDLFTRARTSLNKELEASVELVGLLSSKKALLKEEGISLSSWKEEFDQQATPWLYDHLFEQLQALECDEL 524
157960390 445 LGVGNIGEAWVELFSGAKAALNKELEASVELVGLVSSRNALICDEGIELDSWKQAFEEHATPWQYSHLFEELHDLECDEV 524
157377172 443 LGVGNIGEAWVDLFTRARTSLNKELEACVELVGLLSSKKALLKEEGIGLSSWKQEFEQQATPWLYDHLFEQLQALDCDEI 522
167622563 445 LGVGNIGEAWIELFSGAKSALNKELEASVELVGLVSSRKALISDEGIELGSWKQAFEEHATPWQYSHLFDEVHELECDEV 524
127511455 445 LGIGNIGEAWIDLFKRARPVLNKELEVSVELVGLLSSKKALLSETDIDLSSWQQAFEERGTGWQYTHLFEQLQALNCDEL 524
212637260 445 LGVGNIGEAWIDLFDGARAALNKELEASVDLVGLVSSRKALISDKGIALNTWKSAFEQDATPWQYSHLFEELQGLECDEV 524
71281091  471 AGMGNIGERFLELLPAQLNKVYALENLH--LVGLLSSKKALINNDGIDVNQATSLFAQEAQSYDHEQLISWLTQNPYDEL 548
56461566  461 IGRGNIGTAWLELFRQQRDRINQV--MDVRVMGIANSRRLWLDYNGVELTQWAEDFDRLARPYVLTELLRELPNAPYDEL 538
290477220 545 VVLDVTASEELAKDYIDFASYGFHVISANKIAGSSNSNTYRMVRDAFAKTGRHWLYNATVGAGLPINHSVRDLRESGDTI 624
294142510 523 VALDISASADLTLQYPEFFARGIHVVSANKLAGSGPLAFYKELKQQLGNRRLFWRYNASCGAGLPVQHALNDLHNSGDTI 602
170724988 525 IALDISASADLTLQYPEFFARGIHVVSANKLAGSGPLAFYHELKQQLGNRRLFWRYNASCGAGLPVQHALNDLHNSGDNI 604
157960390 525 IALDISASADLTLQYPEFFARGIHVVSANKLAGSGPLTFYRELKQQLDNRRLFWRYNASCGAGLPVQHALNDLHNSGDSI 604
157377172 523 IALDISASAELTLQYPEFFARGIHVVSANKLAGSGPLAFYRELKQQLGNRRLFWRYNASCGAGLPVQHALNDLHNSGDSI 602
167622563 525 IALDISASADLTLQYPEFFARGIHVVSANKLAGSGPLTFYRELKQQLDNRRLFWRYNASCGAGLPVQHALNDLHNSGDSI 604
127511455 525 IALDISASADLTLQYPEFFARGIHIVSANKLAGSGPLAFYQELKQQLGNRRLFWRYNASCGAGLPVQHALNDLHNSGDSI 604
212637260 525 VALDISASADLTLQYPEFFARGIHVVSANKLAGSGPLPFYRELKLQLGNRRLFWRYNASCGAGLPVQHAINDLHNSGDSI 604
71281091  549 IVVDITPSEDFSLLYEQMFALGVHVIGANKWAASSSTAHYNNLVNTADSHNSLWLGNTTVGAGLPINYAIDDLRQSGDSI 628
56461566  539 VVIDLTDAKQVAQLYPSLFANGLHIISANKRAGSADEALYREIRTIQHEYKREWLYNTTVGAGLPLNYAINDLRNSGDEI 618
290477220 625 LSISGIFSGTLSWLFLQFDGSVPFSDLVEQAWQQGLTEPDPRIDLSGQDVMRKLIILAREAGYEIEPDQVRVESLVPVEA 704
294142510 603 EAVGGIFSGTLCWLFEKYDAKKPFSELVLEARGLGITEPDPRDDLSGRDMQRKLLILAREIGHEIELEDIELKSLVPADL 682
170724988 605 EAVGGIFSGTLCWLFENYDAEKPFSQLVLEAKGLGITEPDPRDDLSGRDMQRKLLILAREIGHDIELEDIKLNSLVPAEL 684
157960390 605 EAVGGIFSGTLCWLFENFDAKKPFSELVIEARGLGITEPDPRDDLSGRDMQRKLLILAREIGFEIELEDIELKSLVPANL 684
157377172 603 EAVGGIFSGTLCWLFENYDANKPFSELVLEAKGLGITEPDPRDDLSGRDMQRKLLILAREIGHEIELEDIELNSLVPSAL 682
167622563 605 EAVGGIFSGTLCWLFENFDAKKPFSELVIEARGLGITEPDPRDDLSGRDMQRKLLILAREIGFEIELEDIELKSLVPDNL 684
127511455 605 EAVGGIFSGTLCWLFEHYDAKKPFSELVLEAKGLGITEPDPRDDLSGRDMQRKLLILAREIGYDIELDDIELESLVPTKL 684
212637260 605 EAVGGIFSGTLCWLFENYDAVKPFSELVVDARGLGITEPDPRDDLSGRDMQRKLLILAREIGLEIELEDIELKSLVPAHL 684
71281091  629 SELSGIFSGTLSWLFETYDGSSKFSELLLNALAQGITEPDPREDLSGRDVQRKLLILARKAGFELALDDIDCQNLVPEAL 708
56461566  619 RSISGIFSGTMSWLFENFTKGVTFSSLVKEAKERGYSEPDPREDLSCQDLVRKLLILAREIGLKLDWQDIEVKSLVPEHL 698
290477220 705 RTGSIEDFFENSAVINEQMLQRLEASQEMGMVLRYVARFDatSG----KAKVGVEAVRADHPLASLLPGDNVFAIESRWY 780
294142510 683 ADIPLDQFLTRIHELDHEMLQEFQAAAEQNKVLRYVAGLDvvNGq--lKAAVGMEWVETQHAYANLTPGDNVFVIRSQFY 760
170724988 685 ADIPLEQFLVRISELDEEMLAQFNSAAELNKVLRYVAGLDfiDGe--lKAEVGIEWVDREHAYANLTPGDNVFVIRSSFY 762
157960390 685 AEIPLEQFLSRITELDDEMQQQFIAAAEQDKVLRYVASLDkvDGe--lKAEVGIQWVDISHPYANLTPGDNVFVIRSEFY 762
157377172 683 ADIPLEQFLGRITELDGEMLQQFQAAAEQDKVLRYVAGLDviEGq--lKAAVGIQWVDREHAYANLTPGDNVFVIRSAFY 760
167622563 685 AELPLEQFLLRISELDADMLQQFVAAAEQDKVLRYVASLDkvDGe--lKAEVGIQWVDISHPYANLTPGDNVFVIRSEFY 762
127511455 685 AEIPLDDFIKRMAELDGEMLQQYQAAAEQNKVLRYVASLDseQGq--lKAKVGIQWVDRSHPYANLTPGDNVFVIRSDFY 762
212637260 685 AELPLEQFLSRINELDEDMLQQYLAAVEQDKVLRYVAALDrvDGk--lKAEVSLQWVDNSHPYANLTPGDNVFVIRSKFY 762
71281091  709 QALSTSEFLARANELDEYFATALSEANRKGACIRYVARFQh-NPetgiSAKVSLEVLPQSDAFANLTPCDNIFQISSHWY 787
56461566  699 RDLPLSEFMQRLSELDEPMTAMLDEAAKDGKVPRLLASFTv-SDeqrvTAQVGIEYIPEGDMLANLIPGENIFVIYTDWY 777
290477220 781 RDNPLVIRGPGAGRDVTAGAIQSDLNRLSQLL 812
294142510 761 QDNPLIIRGPGAGREVTAAAVQSDLAQICRDL 792
170724988 763 QDNPLIIRGPGAGREVTAAAVQSDLAQICRDL 794
157960390 763 QENPLIIRGPGAGRLVTAAAVQSDLAHICRDL 794
157377172 761 QDNPLIIRGPGAGREVTAAAVQSDLAQICRDL 792
167622563 763 QDNPLIIRGPGAGRLVTAAAVQSDLAHICRDL 794
127511455 763 QDNPLIIRGPGAGREVTAAAVQSDLAQICRDL 794
212637260 763 QDNPLIIRGPGAGRQVTAAAVQSDLAHICRDL 794
71281091  788 QDNPLIIRGPGAGRDVTAGGLHSDLVKICQQL 819
56461566  778 SEMPLVISGPGAGKHVTAGGVQSDLNQLLSKL 809
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