Conserved Protein Domain Family
FOG_N

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pfam15888: FOG_N 
Folded gastrulation N-terminus
This is the N-terminal domain of the folded gastrulation protein. Folded gastrulation is required for morphogenic movements during gastrulation and nervous system development. It may act as a secreted signal and activate the G protein alpha subunit. This domain may be the G protein-coupled receptor ligand.
Statistics
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PSSM-Id: 464925
Aligned: 9 rows
Threshold Bit Score: 108.794
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001846893  61 ITPKSIFIAPQLNgfngslCPPDMKVdYNGKCIQVqSNINPAD---IVLTKLQSLL---GDGGGVSNAG-GNEDYD-Y-- 130 
XP_002064189  69 VTAKSIFTLPFRR------CPPGHKL-YNERCIPQ-TNIDPED---VLKQELILAGgggVGGPGNGGSPvIITDYD-Yg- 135 
EDW27033      56 VTAKSIFTLPFRH------CPPGHTL-YNEHCIPQ-INIDPAD---LLKQELIYAn---AGAPGSGSPTaIITDYD-Yse 120 
XP_001966410  60 VTAKSIFTLPFRH------CPPHHTL-YNELCIPQ-SNINPNQ---LIVQELILA-----ETANGKPPPaPIADYD-Yg- 121 
NP_001259783  58 ITAKSIFTLPFRH------CPQGHTL-FNQLCIPQ-SNIDPTD---LVKQELILA-----GGSNGSPPPpPIGDYD-Yg- 119 
XP_004932512  72 ITTKSLFITPLV-------CPKGQRLdGNG-CVQT-VTVNKDEherILLEELNAQFkptLSGD--------VTYYDnY-- 132 
OWR45298     109 ITTKSLFITPLV-------CPKGHRLdGAA-CVQV-VTVNKDEherILLEQLNALHiftAAPNNS------DVFYD-Y-- 170 
XP_002055190  77 VMPKSIFALPFRH------CPPGHKL-YNERCIPQ-INIDPTD---LVAQELQGA----LGEGGEVSSGsP-TDYD-Y-- 137 
EDW00438     109 VMPKSIFALPFRN------CPQGHKL-YNDRCIPQ-ININPTD---VAAQELQGQ----VGESGG--SQiPLTDYD-Y-- 168 
XP_001846893 131 ---EYDTSGPFQVNLplsidlPMEEPP---KRAESFYDTMLVDVPSSLTTTTGQ 178 
XP_002064189 136 --dEDEFSDELLYDA------PQQQPL---MQTTGGEDQALPSEDAPLKFNLFE 178 
EDW27033     121 dgsEEVSGDELLYDLe-----PQSQQT---TGEAGGEDQALPSADAPLKFNIFE 166 
XP_001966410 122 --dEPEDSDEIVFDIggi-plPAIGPV-----QPSGQDQALPSEDAPLKFNIFE 167 
NP_001259783 120 ---DDEESEEIVYDLsvi-ptAMQDGL---PPSVGTGDQALPSEDAPLKFNIFE 166 
XP_004932512 133 ---DENEPGPLQLSIpig-ldPLAAP----LQGQGLSDQA--SQGSHDNINKKD 176 
OWR45298     171 ---GDEEPGPLQLSIpig-ldPQVSP----------QDPS--AQNQDLTPNFGN 208 
XP_002055190 138 ---SDSESDEQLYEMslg-pfAQKDQLstqPSASGAEDQALPSEDAPLKFNIFE 187 
EDW00438     169 ---SDSESDEMSYVLplg-tiIQSEPLstlTSPSGAEDQALPSEDAPLKFNIFE 218 
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