Conserved Protein Domain Family
ASKHA_NBD_AtAPY7-like

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cd24043: ASKHA_NBD_AtAPY7-like 
nucleotide-binding domain (NBD) of Arabidopsis thaliana apyrase 7 (AtAPY7) and similar proteins
Apyrase 7 (APY7; EC 3.6.1.5), also called ATP-diphosphatase, ATP-diphosphohydrolase, adenosine diphosphatase, ADPase, NTPDase, or nucleoside triphosphate diphosphohydrolase 7, catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates (NTPs and NDPs). AtAPY7 has been classified as a type IV-A membrane protein. It is important in pollen exine formation. AtAPY7 does not appear to function as a typical apyrase.
Statistics
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PSSM-Id: 466893
Aligned: 7 rows
Threshold Bit Score: 504.679
Created: 25-Jan-2023
Updated: 27-Apr-2023
Structure
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Aligned Rows:
 
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:The catalytic residue Glu functions as a general base to deprotonate a water nucleophile for direct attack of the terminal phosphate group.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
F4JSH1     145 YYVVFDCGSTGTRAYVYQAsinyk----kdssLPIVMKSLTEGisrk--------------srgRAYDRMETEPGFDKLv 206  thale cress
PNW85089    39 YVAVIDCGSSGTRVYVFTWkykp-----srphLPHIEVIPPSAaadlvp----------kkpgiSSYNRVETLPGLDAFa 103  Chlamydomonas re...
PNR37591   158 FAIVLDGGSTGTRVHVHGWarsp------kdsLPVMVDPTTNThlpgapm-------qvvngkqRLYKRVETEPGLDKLy 224  Physcomitrium pa...
PRW21038    67 HVLVIDAGSSGTRMYAYSWrqatsggaprleaVPSTAAPHKVPrral--------------pdkRAYQRVETEPGLDAFa 132  Chlorella soroki...
EFJ32359    95 FAIVMDCGSTSTRVYVYGWvhn-------ggsIPVMYRPPSHSsana--------------rvkKAYHRMETEPGFHQLl 153  Selaginella moel...
PTQ48634   154 YAIVMDCGSTGTRVHVYAWthemm---lgkdsLPVMVHPSSVYsgpqkydgaptfdkgkrqgesRAYKRMETEPGLDKLl 230  liverwort
GAQ92229    45 YAVVMDSGSTGTRCYVYSWarsg------awgLPKVVDSTAKLgraer-----------fgqkrTAYKRVETEPGLDQFv 107  Klebsormidium ni...
Feature 1                                                                                     #
F4JSH1     207 n--nrTGLKTAIKPLIQWAEKQIPknahrtTSLFVYATAGVRRLrpaDSSWILGNVWSILAkSPFTCRREWVKIISGTEE 284  thale cress
PNW85089   104 drppgDLEGAALGPLLDWARAVVPvrqlpaVPIFLFATAGVRRMqpdKQRLLMQRTRGVLRdSGFRFEDSWARIISGTDE 183  Chlamydomonas re...
PNR37591   225 l--nsTGIENALGPLLDWAGRHIPrhayrnTQVFLLATAGLRRLpvdQSDWILDQAWTVLEnSPFKCKRSSVKVIKGIEE 302  Physcomitrium pa...
PRW21038   133 dd-aaGLQAKALGPLLEWAAAVVPrsqrprTPVFLFGTAGLRKLseeQQARLLDGCRAVLGaSFFRFDPSWVRIISGTDE 211  Chlorella soroki...
EFJ32359   154 h--neSGLGAAVQPLLDWAKQQIParlhgeTPLLLLGTAGLRKLatvDSEWLLDKAWGIIEkSPFKCRRSWLRIINGVEE 231  Selaginella moel...
PTQ48634   231 h--neSGVQGAIEPLIEWAGKQIPrsshkrTKLFFLATAGLRKLpptDSGWLLDKAWSSLErSPFLVMREWVRIISGQEE 308  liverwort
GAQ92229   108 g--dvVKVNQALDPLIQYALKEVPeskrpiTPVFLFATAGLRRLpqaDSAWLLQMAQQMLSaSPFLFEPEWARIISGQDE 185  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     285 AYFGWTALNYQTSMLgalp------------------------------------------------------------- 303  thale cress
PNW85089   184 GVYGWIALNYLRGSFdsptghaaaaaaiesalrqgqhveeqrrglaesagggalgrrggggggaggggggeqaaggadad 263  Chlamydomonas re...
PNR37591   303 AYYGWIALNYKFGRLgnvpk------------------------------------------------------------ 322  Physcomitrium pa...
PRW21038   212 GVYGWIALNYLADTLqgggs------------------------------------------------------------ 231  Chlorella soroki...
EFJ32359   232 AYYGWVALNYILERLgqdetk----------------------------------------------------------- 252  Selaginella moel...
PTQ48634   309 AYYGWIALNYNQDRLgrss------------------------------------------------------------- 327  liverwort
GAQ92229   186 AVYGWIALNYLTGKLsqgq------------------------------------------------------------- 204  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     304 ------------------------kkatFGALDLGGSSLQVTFEneerth------------------------------ 329  thale cress
PNW85089   264 aagtavvsardagagaaaggsaagagvtVGSLDLGGSSLEMVYCssvvprelwqreqrkrelvrphrgggggggggssss 343  Chlamydomonas re...
PNR37591   323 ------------------------klsnYGTLDLGGSSLEVTFEprdvph------------------------------ 348  Physcomitrium pa...
PRW21038   232 ------------------------sggtVGALDLGGSSLEVTFAaeavpw------------------------------ 257  Chlorella soroki...
EFJ32359   253 -----------------------mtlgtVGSLDLGGSSLEVTFEpgepir------------------------------ 279  Selaginella moel...
PTQ48634   328 -------------------------kdtFGALDLGGSSLEVTFEpdrtpp------------------------------ 352  liverwort
GAQ92229   205 ------------------------eaapLGSLDMGGSSLEVTFLpeamps------------------------------ 230  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   344 sssgggaaasggggatsgsnhggtagadtagagqltgghaatvdslggrsyrgqvqlrrlaqerrevvaaaekevaaeed 423  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   424 eleqevasaaqeagqkrpgqaregqeheqegqarrgvrgdggeaqggaadgraggaeagadgaaagaeggrrdtvtatdt 503  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   504 hlerdqglrrkrqeqgqhereegrggrhevrryrgevagahtaagaaavavgiaaarasgevaagsgaaaaggggggggg 583  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     330 ---------netnlNLRIGSVNHHLSAYSLAGYGLNDAFDRSVVHLLkklpnvnk------------------------- 375  thale cress
PNW85089   584 sgggggsggggggrLLVLGAHAYQLRTHTFQKYGLNDAFDRSVSLLLkdvlapppppspqqqlgaggaggglgaagaeat 663  Chlamydomonas re...
PNR37591   349 ---------geygmNLSVGSTEHHLYAASYAGLGLNDAFEKSVALLLraqnatkrd------------------------ 395  Physcomitrium pa...
PRW21038   258 ---------kedavNATVLDATHQLYAHVHHHYGLNDAFDRAVTLLLahqqtggsdaqqqqagdggaggaaaagakpqeg 328  Chlorella soroki...
EFJ32359   280 ---------pdygvNLSFGQEEHRVYAYSHSGFGLNDAFDKSVALLMhnsnv---------------------------- 322  Selaginella moel...
PTQ48634   353 ---------aaygvNVSVGSEEHHLYAYSHPGFGLNDAFEKSVALLIqrgeyt--------------------------- 396  liverwort
GAQ92229   231 ---------sehgvNVTIKETDYHLYAHSHPSFGMNDAFQKSVLFAMednga---------------------------- 273  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   664 ddsldvlqrefatkpqrpallrqgdlhppppplapteqqqqqqqqqqqqvegnstaavdrrsdlstaalagisssgdnpt 743  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038   329 raaaeqsaevaaatgvgaaaeaat-------------------------------------------------------- 352  Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   744 vaalahaasasssnssssgaaaapaqqgagaavgtdaaaeaaqaqlagaaakqsageaaaasvgtelqassgaaagagtg 823  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   824 daggqghtasgvsvggdaavavamggeltaqaaaaatgaggagaaagaaagaaggaaggaaagagataggaggaaaklrs 903  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   904 qaavleqqkrdseriiqlvkeqlamaaaqghavngsavsasagtaaaagggaaggggagggagaasastaagaataaeam 983  Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089   984 agatsadaaaaaagraaqvaaavsgggasqhesdqgaaadsaaagaaarsadgsdggsgsgssaasalrrllsrlsvgfv 1063 Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089  1064 esvapkrravdrsglalpirrhsrlqdgaagggaaadgvaaaataaevggsshgsagaggdtagaaaaglgvthtdadsd 1143 Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229       --------------------------------------------------------------------------------      Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     376 -------------------------------------------------------------sdliegkLEMKHPCLNSGY 394  thale cress
PNW85089  1144 aglaaaaklglaaaaaaataagmgaaagatagvaaaggggagaaggghrggvvvvgrddddvtgrwsgLVVRHPCMHEGF 1223 Chlamydomonas re...
PNR37591   396 ------------------------------------------------------------rkrrssnlLEVEHPCLQTGY 415  Physcomitrium pa...
PRW21038   353 -----------eevagrqdvavgarremlqapaalrrqlrlsgdaailgsghsmqqvlpmgrrllegpPEVEHPCLHSGY 421  Chlorella soroki...
EFJ32359   323 ----------------------------------------------------------------rngtLEVRHPCLHSEY 338  Selaginella moel...
PTQ48634   397 ---------------------------------------------------------------rkkgtIFVQHPCLNPGY 413  liverwort
GAQ92229   274 ----------------------------------------------------------------genaLEVEHPCLHTGY 289  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     395 NGQYicsqcassvq------------------------------------------------------------------ 408  thale cress
PNW85089  1224 SRPYkrvhhyg--------------------------------------------------------------------- 1234 Chlamydomonas re...
PNR37591   416 RAPYkcsthcvlpplparr------------------------------------------------------------- 434  Physcomitrium pa...
PRW21038   422 RKAYrrrqqega-------------------------------------------------------------------- 433  Chlorella soroki...
EFJ32359   339 QQSYscssycvapps----------------------------------------------------------------- 353  Selaginella moel...
PTQ48634   414 KEPFvcshcalppfphanep------------------------------------------------------------ 433  liverwort
GAQ92229   290 NDTYrfkkrrsdaavstsavadkalkeghgrrllrwaaenvpfrskvptsglhslqqsplgssqparaqgvnagqgflka 369  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1         --------------------------------------------------------------------------------      thale cress
PNW85089       --------------------------------------------------------------------------------      Chlamydomonas re...
PNR37591       --------------------------------------------------------------------------------      Physcomitrium pa...
PRW21038       --------------------------------------------------------------------------------      Chlorella soroki...
EFJ32359       --------------------------------------------------------------------------------      Selaginella moel...
PTQ48634       --------------------------------------------------------------------------------      liverwort
GAQ92229   370 ffdtvfrrplvgdselqstpsglhgaftalgrrlrrftlhqdsrqwrkppsdraqipsmrsaqvthaaalttalqasqld 449  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     409 -----------------------------------------------------------------------ggkkgksgv 417  thale cress
PNW85089  1235 --------------------------------------------------------------------------lapgta 1240 Chlamydomonas re...
PNR37591   435 ------------------------------------------------------------------sgrnapssdvgtaa 448  Physcomitrium pa...
PRW21038   434 --------------------------------------------------------------------------avpdpp 439  Chlorella soroki...
EFJ32359   354 ----------------------------------------------------------------------tnrgageggv 363  Selaginella moel...
PTQ48634   434 -----------------------------------------------------------------hkgrrsllaggdfgg 448  liverwort
GAQ92229   450 lvpyphnpsqghrqesvsevgtllhgespifksvstpvsqsasfrstdstsekeiehlssarggaalarrrvleersgpt 529  Klebsormidium ni...
Feature 1                                                                                      
F4JSH1     418 sIKLVGAPNWGECSALAknavnssewsnakhgvDCdl-qPCALPDGYPr-pHGQFYAVSGFFVVYRFFNLsaeasLDDVL 495  thale cress
PNW85089  1241 tLQLVGAPDWAACLALVgrtv--------nasaECggagHCILGWAQPp-lQGRFVVLTGFYVVWKFFGLsagdsPGAVL 1311 Chlamydomonas re...
PNR37591   449 qVELLGAPNWDTCQALAediin------sssvqGCsf-pPCALGKHQPy-pQGTFYGLAGFYVVYKFFGLsqdapLDDLL 520  Physcomitrium pa...
PRW21038   440 eVMLVGRPSYEACKQLAaavv--------aadaPCsa-pPCALGTPQPstsGHRFVALTGFFVVYKFFRLpetagVAALE 510  Chlorella soroki...
EFJ32359   364 pIVLVGEPHWGKCQALArsvinss--rfttrsvDCeq-sNCALGKYQPr-pIGQFYAVAGFFVMYKFFGLsskasLDDLL 439  Selaginella moel...
PTQ48634   449 kVQLVGKSNWSSCQSLAlsvinesglpqttgvsECef-pPCALGKHQPe-pQGQFYALAGFFVVYKFFGLtstdsLNDLL 526  liverwort
GAQ92229   530 sVKLIGRPDWQACQALVdrvv--------tsaeECee-ePCALGAHQPa-lRGNFMALTGFFVVYHFFGLagsvpLDRLL 599  Klebsormidium ni...
Feature 1                                                                          
F4JSH1     496 EKGREFCDKAWqvartsvspqpFIEQYCFRAPYIVSLLREGLYItDKQIIIGSGSitWTLGVALLESG 563  thale cress
PNW85089  1312 AAAQAHCGRPWrrvdselghhiNVEKYCLWGPYVGHLLSAGLGLsHSQFEVGSGDvgWPVGAALAEAL 1379 Chlamydomonas reinhardtii
PNR37591   521 AKGQDFCKLPWkvaersvdpqpSIEQYCFRSPYVTTLLREGLHLqDNQIQIGSGDfsWTLGAALWEAG 588  Physcomitrium patens
PRW21038   511 RAGEEFCGKTWaqvqadrpgelMLEDYCFRAPYIARLLRHGLLLqDEQLRIGSGDmgWTLGAALAEGY 578  Chlorella sorokiniana
EFJ32359   440 SKGQEFCGKPWpvardsvdpqgFIDRYCFRAPYVVALLREGLHLrDEQVTVGPGDvtWTQGAALLEAG 507  Selaginella moellendorffii
PTQ48634   527 IKGHQFCKMKWqdakvsvppqpSIDRYCFRAPYVVSLLLEGLHLrADQIQIGSGDfaWTLGAALNEAG 594  liverwort
GAQ92229   600 DAGQAFCKKTWthvkaeyygerGLDRYCFRAPYVVSLLRKGLGLrDDQIQIGTGDmaWTLGAALYEGG 667  Klebsormidium nitens

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