3NR8


Conserved Protein Domain Family
IPPc

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smart00128: IPPc 
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Inositol polyphosphate phosphatase, catalytic domain homologues
Mg(2+)-dependent/Li(+)-sensitive enzymes.
Statistics
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PSSM-Id: 214525
Aligned: 16 rows
Threshold Bit Score: 282.321
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NR8_B          6 DMISVFIGTWNMGSVp-----PPKNVTSWFTSkglgkt-------------------------------------ldevt 43   human
EDL12828       30 FALSVHVVTWNVASa-----aPTVDLSDLLQLn----------------------------------------------n 58   house mouse
NP_001558     422 DMISVFIGTWNMGSVp-----PPKNVTSWFTSkglgkt-------------------------------------ldevt 459  human
NP_001122420   93 QDVKICVSTFNVNGRs-----PLSVFPTWFSQkp---------------------------------------------- 121  nematode
NP_593565     787 TDVSILICSWNAGASkpsdldSDTIGASMIPMmi---------------------------------------------r 821  Schizosacchar...
AAB08434       24 RDFTIHVATWNVNGRk------PTTITNLIGQns--------------------------------------------dk 53   Rhodnius prol...
NP_014576       4 TNWKVSVTTFNCGKEfpv-enSKAIVKQLLFPydd------------------------------------------gis 40   Saccharomyces...
NP_498783       1 MDWKITIFTYNLAMka----sDSEAVHNMLNGmi---------------------------------------------- 30   nematode
NP_501999      91 RKLKVCTVTWNINE-------KGVKILSHLAQkia------------------------------------------erg 121  nematode
AAB60921      321 ARTRDLIKVFNIDGQle--nrPENSVYPDFGSeeegkmkvtaskkekaqsslgffqrsrnaimgaadavrraatkggfcd 398  thale cress
3NR8_B         44 VTIPHDIYVFGTQE------------------------------------------------------------------ 57   human
EDL12828       59 QDLNLDIYIIGLQEmnfgi------------------------------------------------------------- 77   house mouse
NP_001558     460 VTIPHDIYVFGTQE------------------------------------------------------------------ 473  human
NP_001122420  122 -eDIAEFYAVGLQEmdlsvg------------------------------------------------------------ 140  nematode
NP_593565     822 DNGYPDIVVFGFQElvdlenkrltarsil--------------------------------------------------- 850  Schizosacchar...
AAB08434       54 YENLPDMVIVGLQEvtmsa------------------------------------------------------------- 72   Rhodnius prol...
NP_014576      41 QLELQDLYVLGFQEvvpiwqgsfp-------------------------------------------------------- 64   Saccharomyces...
NP_498783      31 -dDHTHLVAIGLQEvah--------------------------------------------------------------- 46   nematode
NP_501999     122 QEMDSDIFFISLQEipstaptfh--------------------------------------------------------- 144  nematode
AAB60921      399 DSRKTEAIVISVDGmiwtgssngilmrwdgngnclqefayessgilcmftfcsrlwvgysngtvqvwdlegkllggwvah 478  thale cress
3NR8_B         58 -----------------------------------------NSVGDREWLDLLRGGLKel-tdLDYRPIAMQSLWNIKVA 95   human
EDL12828       78 ------------------------------------isllsDAAFEDPWSSLFMDMLSp----LNFVKISQVRMQGLLLL 117  house mouse
NP_001558     474 -----------------------------------------NSVGDREWLDLLRGGLKel-tdLDYRPIAMQSLWNIKVA 511  human
NP_001122420  141 ------------------------------------tyiidNTKKMEGWVDAIHCSLPgg--rTQFNVVGSMRLVGIFVI 182  nematode
NP_593565     851 ---------------------------skssskggssnsanISSQYRLWREKLESEMMrvssnDDYQVLVCENLVGLFSC 903  Schizosacchar...
AAB08434       73 ------------------------------------vkavsNALTGELWSETMEKTLKg-----nYQKVKSVALLGIVLN 111  Rhodnius prol...
NP_014576      65 --------------------------------avnrdlidrITTTAVNCLNEKVSATQg---dEQYSCLGVNSLGAITII 109  Saccharomyces...
NP_498783      47 --------------------------------------setIGGAVLTWATTIASWMNt---nGRMVLLAKTFQATNQVL 85   nematode
NP_501999     145 --------------------------------eealrilepVLNGHRLYLSHRAWSQM--------------------VI 172  nematode
AAB60921      479 sgpvikmaigagylftlanhggirgwnvtspgpldnvlraeLAGKEFLYSRIENLKILa----GTWNVGEGRASTDSLVS 554  thale cress
3NR8_B         96 VLVKPEHENR-ISHVSTSSVKTGIANTL---GNKGAVGVSFMF-NGT------SFGFVNCHLTS--GNEKTARRNQNYLD 162  human
EDL12828      118 VFAKYQHLPY-IQIISTKSTPTGLYGYW---GNKGGVNVCLKL-YGY------YVSIINCHLPP--HMYNNDQRLEHFDR 184  house mouse
NP_001558     512 VLVKPEHENR-ISHVSTSSVKTGIANTL---GNKGAVGVSFMF-NGT------SFGFVNCHLTS--GNEKTARRNQNYLD 578  human
NP_001122420  183 VFQAVNSKVR-VSDVNVKYVATGISVLVnklGNKGGTAVSMKM-NDT------WVCFVNAHFAA--GNNELERRNQDFRD 252  nematode
NP_593565     904 VFVKNKLQSK-IRMLQSTTVKTGLGGLH---GNKGAIVVRFLV-DDT------SYCIVNCHLAA--GQSNKAARNNDLAT 970  Schizosacchar...
AAB08434      112 VFVKLNSAWA-LKNAAVDEVTTGMAGLY---GNKGGVIMKFQL-HDL------MFCIVNAHFHA--HDKGQESRIKDYKE 178  Rhodnius prol...
NP_014576     110 VLYNNNAL-K-VKDDILKRNGKCGWFGT---HLKGGTLISFQM-TRNgeenweRFSYICAHLNAneGVNNRNQRIDDYKR 183  Saccharomyces...
NP_498783      86 IFGRKQLIGQ-IKRIDYRFQRNTMGGLT---GHKGSIGVRLQLaSPY------SIVFVDSHFIH--GPENYGKRVEQYHT 153  nematode
NP_501999     173 VFIRQKHLRYaIQPQVSFIASGAMAKPV---RTKGAIAVCLRL-YQR------FIVLIGCHLSH--ATP--QQRIQDYAK 238  nematode
AAB60921      555 WLGCAATGVE-IVVVGLQEVEMGAGVLA---MSAAKETVGLEG-SPLgq---wWLDMIGKTLDE--AGASFGVTMPRGGN 624  thale cress
3NR8_B        163 I-L-RLLSLGDRQLNA------------Fdi---sL-------------RFTHLFWFGDLNYRLDMDI-----QEILNYI 207  human
EDL12828      185 I-L-ESLTFEGYDVPN------------I------L-------------DHDLILWFGDMNFRIEDFGl----LFVQESI 227  house mouse
NP_001558     579 I-L-RLLSLGDRQLNA------------Fdi---sL-------------RFTHLFWFGDLNYRLDMDI-----QEILNYI 623  human
NP_001122420  253 IyN-DMVFYPRSQQEGlrdrplevpimcL------Y-------------DHDVVFWFGDLNYRLNTDMygisnDEVRRIA 312  nematode
NP_593565     971 I-LdNASLFPENDETD------------Q------LntfvgggdgslimDHEVCVLHGDLNYRINTLRp----KAL-DLI 1026 Schizosacchar...
AAB08434      179 I-N------EGREKLC------------T------P-------------KSDFIFWLGDLNFRIVEKDky-tpESIEKFI 219  Rhodnius prol...
NP_014576     184 I-M-SEVCDSEVAK------------------------------------SDHFFFLGDLNFRVTSTYdp--tTNYSSTT 223  Saccharomyces...
NP_498783     154 N---RNCSFPEDKS------------------------------------VRAAFWFGDFNFRVE--------EDVNTVI 186  nematode
NP_501999     239 V-V-RTLRFPQLARFH------------AhakdeiF-------------GSDVVLWIGDLNFRVTVESnv--dWRDPEKI 289  nematode
AAB60921      625 A-L-GVNTIEARPELS------------E---------------------ADMVIFLGDFNYRLDDITy----DETRDFI 665  thale cress
3NR8_B        208 SRKE----FEPLLRVDQL--NLEREKHKVFLRFSEE-EISFPPTYRYErgsrdtYaWHKQKPTGvrtNVPSWCDRIL-WK 279  human
EDL12828      228 TRKY----YKELWEKDQL--FIAKKNDQLLREFQEG-PLLFPPTYKFDr-------HSNNYDTSekkRKPAWTDRIL-WR 292  house mouse
NP_001558     624 SRKE----FEPLLRVDQL--NLEREKHKVFLRFSEE-EISFPPTYRYErgsrdtYaWHKQKPTGvrtNVPSWCDRIL-WK 695  human
NP_001122420  313 SSDK----FADLLQHCQL--REQMARGTVFKDFEEPsTLPFRPTYKYDc-------GTNTWDTSekgRVPAWTDRIL-TF 378  nematode
NP_593565    1027 KKND----IKTLLQSDQLlvERKRNAGFRLRTFTEP-EITFAPTYKYDv-------HSEQYDSSekkRVPAWCDRIC-YR 1093 Schizosacchar...
AAB08434      220 KKKD----YDELLANEQL--KEAKDAGKIFKDYQEG-KIKFAPTFKLNv-------DEGTYNLk---RRPSWTDRVL-YK 281  Rhodnius prol...
NP_014576     224 TLRR----LLENHEELNL--LRKGEDEPLCKGFQEL-KITFPPTYKFK------LfEKETYNTk---RIPSWCDRIL-YK 286  Saccharomyces...
NP_498783     187 RKIKngthLELLDTREQL--KRALVERDAFIGFHEQ-PVTFEPTYRV-------TvGTTEQDGk---RVPSWTDRIL-YK 252  nematode
NP_501999     290 TEKT----FRDVFETEEL--ASHRKKQLAFTDFKEA-PIKFPPTHKFEp-------DTDNYvp---kRIPSFTDRVLfWV 352  nematode
AAB60921      666 SQRC----FDWLREKDQL--HTEMEAGNVFQGMREA-IIRFPPTYKFEr----hQaGLAGYDSGekkRIPAWCDRIL-YR 733  thale cress
3NR8_B        280 s----------------YP--ETHIICn----------sYGC---TDDIVTSDHSPVFGTFEVGVT 314  human
EDL12828      293 lkrqpsqasplassvptSY--FLLTLKn-----------YVS---HMAYSISDHKPVTGTFDLELN 342  house mouse
NP_001558     696 s----------------YP--ETHIICn----------sYGC---TDDIVTSDHSPVFGTFEVGVT 730  human
NP_001122420  379 k---------------kYP--QVGLESir---------pMVS---IDTITISDHKPVRAMFNLKVK 415  nematode
NP_593565    1094 g----------------SP--DYISAEn-----------Y-T---RYELKASDHRPVSALIHSKAK 1126 Schizosaccharomyces pombe 9...
AAB08434      282 se--------------tNK--NIDVLa------------YHS---LENHTRSDHFPVMAQYKIKVP 316  Rhodnius prolixus
NP_014576     287 sy--------------aVP--TFAQEGt-----------YHSvprSNALLFSDHQPVNLTVRLPRS 325  Saccharomyces cerevisiae S288c
NP_498783     253 -----------------GD--GITGLS------------YTN---NKKAVASDHLPVVAMFRVTAP 284  nematode
NP_501999     353 r---------------nSEwlQNIQ--------------YDC---MRGTTPSDHKAVFATFWLTVi 386  nematode
AAB60921      734 d---------------nKK--HLGAECsldcpvvssisqYDA---CMEVTDSDHKPVRCVFSVKIA 779  thale cress
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