Conserved Protein Domain Family
PHA-1

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pfam06542: PHA-1 
Regulator protein PHA-1
This family represents the protein product of the gene pha-1 which coordinates with lin-35 Rb during animal development. The protein is expressed during embryonic development and functions in the cytoplasm. PHA-1 acts in a parallel pathway with UBC-18 to regulate the activity of a common cellular target.
Statistics
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PSSM-Id: 368965
Aligned: 9 rows
Threshold Bit Score: 446.528
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGT60115      69 VNKSFNSVILSKVRSEYVQIQVSPILKPETNGEysdneeaeDDm--nQQDRKFTINDQRVSLSTAPKFFDFLNNVARIRV 146
1_pfamImport   1 VSRSFNNVVLSKVRAEFKMVQVCPYQQPEGADEkee---peYDesndIEDRSFMINDRRTWFSQVPRFFEFLNSVARIRV 77 
XP_003108853  67 VSKAFNNVVLSKVRAEFVTVQVSPCHIIGTNGEyseceeheDNd--tNTDRSFTVNDRKVWFHQVPKFFEFLNSVARIRV 144
Q19309        80 IKKSFNEAVLHKIRKDHREVVLHTAYHCDVADEyteymgtdYE----CRYCYIYLNYQKVTSNKMSSFFRFLKDTVAVKI 155 Caenorhabditis ...
Q7YXC4        51 VNKSFNLAAIHVIRKENRTVVFHKFNRCDRLHKis-----------pCPDCSVHLNSVKLNKKNIFQYARFLKQTMKIMV 119 Caenorhabditis ...
Q9U2D4        51 VNKAFNFGIIHSIRIEHQTVIFHKPTRCDIIRR--------------CPNCTVNLNSVELNVKNIRKYARFLKQTMKITV 116 Caenorhabditis ...
O17552        56 VNKNINIALLRRIRQEHRDVLIRGASDCRFDLE--------QDakqnCPDCSVFINPQRVTMEKLEDYFRFLKEIAGVKV 127 Caenorhabditis ...
NP_001255195  39 VSRHLNLAVLYKIRKEHSEIIIHNLGHCDKHLP--------------CI-CTVFINSQDICNLKLHAYFQFLNKRVKINI 103
XP_045097094  97 VSKLFNHVILSKIRAAFVQVQVSPDQKLDSCGEnsdneeseEDqvasLQDKSFILNDRRVVFRHVPKFFEFLNSVARIRV 176
EGT60115     147 RDLLF--------SGFTQPDKR-VHDCILYSLMDATWFSLNSYKGAEEVC-NGCA-ACTEIAARVNIYGPIQLcTLLEPI 215
1_pfamImport  78 RDLLF--------SGFTSPDQR-IHECILYSLLDGNWYSLNSYKGADELC-NGCA-VCSEIASRVSIYGPVQFcTLINPI 146
XP_003108853 145 RNLLF--------SGFISPDQR-LHKCILYSLLDGNWFSLYSYKGADEVC-IGCT-ACQEIASRVRIYGPVQLcTLVEPI 213
Q19309       156 VKLILepargfpfSHFCLNNDLlFHNIIMNDLIGNNYKSILHFEGMIDIClHGCF-DCMRIMLNCEVYGPAQI-NVIR-- 231 Caenorhabditis ...
Q7YXC4       120 IKIRIe------dSKRVCCMITdVHQVIHKSLIGSDYDKVEEFVGIDQISfSTCI-PCEKIAANCKVFGPVQN-DMFNAI 191 Caenorhabditis ...
Q9U2D4       117 FKIIIe------dLEFSCIDREiIHLALNDLFTDSDYERVEEFIGVDNICiAGCG-ECRKMIQNCKVYGPIQL-DIFQSV 188 Caenorhabditis ...
O17552       128 RRVGVed-----vAKICDQREI--HDRVINSLIGNDDQLVEEFFGMNDIC-SGSD-ECGIIGGRCRKYGPIQE-NIFDIT 197 Caenorhabditis ...
NP_001255195 104 CKLQVq------iEHFDKVVQFqLHRLILKELIGSNEDRIREFTGMFDLSyYGWDlKAERIARHCIRFGMQEGvDLHGSQ 177
XP_045097094 177 RDLLF--------SGFTSPNEY-LHKCILYSLLNGNWFTLCSYKGADEIC-NGCS-ACKEIASRVKIYGPVQLcTLFEPI 245
EGT60115     216 C-GKKHYEQLIVTEILLAEIAF-------YCVTMIGSKEEAFVRLAKVITPEISCDQLDLVFSDRCMWSKDTLAHP---- 283
1_pfamImport 147 L-GKKSYEQLIVTEILLAEIAL-------HCVTMVGSREEAFSRLTKMITQDVNCDQLDLVFSDRCMWSKGTLAHP---- 214
XP_003108853 214 R-GRKHYEQLIITEILLAEIAV-------HCITMVESKAEAFNRLTKIITPEISCDQLDLVFSDRCMWSKQTLSHP---- 281
Q19309       232 RkEPKHFKELELPEVMAD---LpddppnmEFKVGIENWE-----MESIKKTKISCDKLILRLSH--------SAVPnpri 295 Caenorhabditis ...
Q7YXC4       192 LrLKHHYDVLQVKDMRLYKLMI-------------LNKE-DPTVVEDFINSNITCSKLTIFLMYMYEKEAFGYSLP---- 253 Caenorhabditis ...
Q9U2D4       189 MgQKRSFDALQITDEDLYVLLW-------------LNKQKDPKLVENFINSIITCSKFTIFLTSIFEKKELGHSLP---- 251 Caenorhabditis ...
O17552       198 LkTPHHFEHLEVSDTLLHRIVL----------SLADSSQSNLAVIDKYINSRISCDSLTLMPSILLGTRK--SWIPcql- 264 Caenorhabditis ...
NP_001255195 178 L---LNFDVFEVAEPHLHGIVNadkfevrRIYTDEEDEEMVYFPINRFLKMPITCDTLTFIL-----YGKDIVSLP---- 245
XP_045097094 246 HeKKKHYEQLIVTEI----------------------------RLASIITSEISCDQLDLVFSDRCMWSKETLSHP---- 293
EGT60115     284 -------REVIDWIVKAWKIKSINV------------RFMT------GYSSIDYKQWACKRVFTEMRFDEMfvkdhnsrp 338
1_pfamImport 215 -------REVIDRIVKAWRVKSINI------------RFMT------EYSSIDHEMWSNKRIFTEMRFDEMfvtdhniir 269
XP_003108853 282 -------REVIDWIVKAWSVKSINV------------RFIT------GYSSIDYNLWASKRVFTEVRFDEMlvkds--lr 334
Q19309       296 wyykyitREVIDIIISNWKVKTVKLiiti----nnmeEFITip--------eQFHLFTKERLGDPISTHPI--------- 354 Caenorhabditis ...
Q7YXC4       254 -------REFLDLLIKKWNVKTVEIvprqdq-----------pipyyFHCNTDFIVP-KAKFYVDYWTQPR--------- 305 Caenorhabditis ...
Q9U2D4       252 -------RELVDMLITKWNVKTVEI------------GFKNvtn-ddFYQNTDYIDP-KAKFYVDYRTQQR--------- 301 Caenorhabditis ...
O17552       265 ----qvmRQIVELIVVKWNVKNLRI------------EFGElpeldlSSGDLDL----NQKLIG-LEFESV--------- 314 Caenorhabditis ...
NP_001255195 246 -------RTITHQAVSNWNAKNVNLnfrfgahnvmaeKFHEcp--------eNFKNPVNIQFVAPWNIEPV--------- 301
XP_045097094 294 -------REVIDWIVKAWSVKSINV------------SFIT------GYSSIDYKLWASQRVFTEMRFDEMfveqn--ts 346
EGT60115     339 rndRRDHFERVEVDMQAG-DEIATCFAQSMgmferSGMSATAFQNVCANVKRIFPTQDMYLILPVEL--AHVASLEFDGF 415
1_pfamImport 270 prhERDHFERVEVDMQAG-DEIATCFAESMgmfeqSGMSATAFQNVCANVKRIFPTQDMYLILPTEL--AHVASVEFDGF 346
XP_003108853 335 rqnERDNFERVEVDMQAG-DEIATCFAESMgmferSGMSATAFQNVCANVKRIFPSQDMFLILPIEL--ARVASAEFDGF 411
Q19309       355 ---SKNSLEKVELDLRFGvNTLVKMFHRSA--------EILPTDNIIENVRRIFPTKNMIITLPNSF--SPLPVEHHCRF 421 Caenorhabditis ...
Q7YXC4       306 ---SKYTLDGVEIDLQLT-KVVEQQIKN----------RKSLFDNFIANARRIFPSNKITVRFSKEVcqEMMSQGNVEDF 371 Caenorhabditis ...
Q9U2D4       302 ---SMYTLDVVEINIKLT-RIMEKC-------------HGSLFNNFVPNVRTIFPSNKITLKLSKEVckVLMNPDNVEDF 364 Caenorhabditis ...
O17552       315 ---ANYSLENLDICLEFS-ELLADEMEQYLk----SPEEPSPIDGLISNVQKIFSTKFLTLELPKAY--ILMTPFNLNKF 384 Caenorhabditis ...
NP_001255195 302 ---SANLLESVEIKLQYT-DDILLTIEDQL-----DYDYYSPYDNIIANVQRAFPSRNMIVKLSETN--VLIAPENMHKV 370
XP_045097094 347 pqnRQDNFDRVEVDMQAG-DEIATCFAESMgmferSGMSATAFQNVCANVKRIFPTQDMYLILPLEL--AHVASAEFDGF 423
EGT60115     416 CEALLEFAWKDERt--aRHSRLFFRLYTfgiTEKEVMRQIEKQFKINCRPVAAMLSDPSVRRsflkwlpgttsAFDRSLL 493
1_pfamImport 347 CKALLEFAWKDERt--aRHSRLFFRLYTfgiTEEQVLRQTENQFKINCRPVAAMLSDSSVRRsflqwlpgstsTFDRSLL 424
XP_003108853 412 CEALLEFAWKDERt--aRHSRLFFRLYTfgiTEQEVMRQIEKTFKINCRPVAAMLSDPNIRRaflkwlpgtttSFDRSLL 489
Q19309       422 VMMFLRMGFPKGQ----RNFNVTWRLFI-----HEPIYGTSPGFKYRNMVIPAFN------------------YKPKPWE 474 Caenorhabditis ...
Q7YXC4       372 ISGIILMTQKDAQ----PNSHISLKLYP---------------EEVDAPLIDSFLRENFEKK-----------FDSWNLE 421 Caenorhabditis ...
Q9U2D4       365 ISGVILMAQNDDH----PNSHISLKLYP---------------QQLRFRLITSFLCDNLVKL-----------FGFWSLK 414 Caenorhabditis ...
O17552       385 IGKFMRMIESSPSsptiRNSKITVKLYP---MSSQLISRTAPVFNYRTQNVPEIL--NSGAR-----------LVSGPID 448 Caenorhabditis ...
NP_001255195 371 FAKFIRLTEQNQQ----RNGSVTFKLYYe--EDDRIPIKVPHIFNSSARLV----------------------------- 415
XP_045097094 424 CEALLAFAWKDERt--aRHSRLFFRIYTfgiTEKEVMRQIEKPFQINCRPVIAMLSSPVVRRsflkwlpgtttLFDRSLL 501
EGT60115     494 SFTDVSNN------------------------------CV 503
1_pfamImport 425 SFTDVWNN------------------------------CV 434
XP_003108853 490 SFTDVSNN------------------------------CV 499
Q19309       475 YESSLQNNhlyfektvklqdeqefsffkevkiwkgnkfCV 514 Caenorhabditis elegans
Q7YXC4       422 TVSDSSANlpae-----------------------kcyQF 438 Caenorhabditis elegans
Q9U2D4       415 SVSKISENerg------------------------ksfHF 430 Caenorhabditis elegans
O17552       449 QIQKNSKDyfhlkdivsipddrsigyrtqvhiwkgrrfCL 488 Caenorhabditis elegans
NP_001255195 416 --GEQPEHcwyldei-----------------lnipkeTI 436
XP_045097094 502 SFTDDSNN------------------------------Cv 511
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