Conserved Protein Domain Family
Pmp3

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pfam01679: Pmp3 
Proteolipid membrane potential modulator
Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organizms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam01679 is a member of the superfamily cl00431.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011932826   5 DLLRIILAFILPPLAVAT-Q----VGlTGA-------FWLNLLFWLlsfggLG-LPllaimwpvAVIHAIYICV 65  Synechococcus sp. WH ...
XP_001482188  13 KILLIIMACVLPPLAVGL---------LNSrcdmrreLVVSIILMF-----FGfFP--------STVFTIYCIF 64 
XP_002546855  16 SFLLIIMAIVLPPLPMYLiD----RSiFSRn------FIICCLLTL-----CGgIA--------GSIFSCYIIY 66 
Q5AD37        17 QFILIVAAIILPPLAIFL-Sk--kYSiWNKe------FWISVVLTL-----IGhIP--------GAIFAVYYLL 68  Candida albicans
XP_001528726  47 QFILIIAGVILPPLAVFL-Ak--rYSiWNKe------FWITLFLTL-----LGhLP--------GLVFAIYWLV 98 
XP_007375158  10 QFILIIAALVLPPLAIFL-Ak--kYSiWNKe------FLVSVLLTM-----FGhIP--------GAIFTLYYLw 61 
CCE43646      13 QFVLVLAAIFLPPLATFL-Aq---RTiFTKe------FLVTVVLTL-----FGhIP--------GSVFAIYFLF 63 
CAR65711      15 NILLIVLSFIIPPVPIIM-Ls--dNSiFTKe------CLISVILTL-----LGhIP--------GVLFSLYYIL 66 
EGV60767       7 kSLLCLLAFFLPPAPVFMlQ----KTiFTKe------FLVSVLLTL-----MAhFP--------GLLFSLYFII 57 
XP_002615495  18 KYLLVLMALLLPPLPIFL-LtspkHTiRTKe------FFISFLLTF-----LMyFA--------GILYSIYFIC 71 
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