1AXM,1AFC,1BAR,1DZC,1E0O,1EVT,1FMM,1HKN,1JQZ,1JT3,1JT4,1JT5,1JT7,1JTC,1JY0,1K5U,1K5V,1M16,1NZK,1P63,1PZZ,1Q03,1Q04,1RML,1RY7,1YTO,1Z2V,1Z4S,2AFG,2AQZ,2AXM,2HW9,2HWA,2HWM,2HZ9,2J3P,2J3P,2K43,2NTD,2Q9X,2RQ9,2UUS,3B9U,3BA4,3BA5,3BA7,3BAD,3BAG,3BAH,3BAO,3BAQ,3BAU,3BAV,3BB2,3CQA,3CRG,3CRH,3CRI,3CU1,3FGM,3FJ8,3FJ9,3FJA,3FJB,3FJC,3FJD,3FJE,3FJF,3FJH,3FJI,3FJJ,3FJK,3HAL,3JUT,3OJV,3UD7,4J23,4Q91,4Q9G,4Q9P,4QAL,4QBC,4QC4,4QO3,4XKI,4YOL


Conserved Protein Domain Family
beta-trefoil_FGF1
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cd23313: beta-trefoil_FGF1 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 1 (FGF1) and similar proteins
FGF1, also called acidic fibroblast growth factor (aFGF), or endothelial cell growth factor (ECGF), or heparin-binding growth factor 1 (HBGF1), plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation, and cell migration. It functions as potent mitogen in vitro. FGF-1 acts as a ligand for fibroblast growth factor receptor 1 (FGFR1) and integrins. It interacts with FGFR1, FGFR2, FGFR3, and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. It also interacts with fibroblast growth factor-binding protein 1 (FGFBP1), FGF1, and FGF2. It can induce angiogenesis. FGF1 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
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Statistics
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PSSM-Id: 466999
Aligned: 91 rows
Threshold Bit Score: 266.691
Created: 2-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ligand binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1AXM; Homo sapiens FGF1 in complex with heparin fragment, contacts at 4A
  • Citation:PMID 9655399
  • Structure:1AFC; Bos taurus FGF1 bound with anti-ulcer drug sucrose octasulfate, contacts at 4A
  • Citation:PMID 7520817
  • Structure:1E0O; Homo sapiens FGF1-FGFR2-Heparin complex, contacts at 4A
  • Structure:1RML; Homo sapiens FGF1 bound to 1,3,6-naphthalene trisulphonate, contacts at 4A
  • Citation:PMID 9719643
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                                                                       
1AXM_A      5 KPKLLYCSNgGHFLRILPDGTVDGTRDRsDQHIQLQLSAESvGEVYIKSTeTGQYLAXDTDGLLYGSQTPnEECLFLERL 84  human
1AFC_A     10 KPKLLYCSNgGYFLRILPDGTVDGTKDRsDQHIQLQLAAESiGEVYIKSTeTGQFLAMDTDGLLYGSQTPnEECLFLERL 89  cattle
1BAR_A     10 KPKLLYCSNgGYFLRILPDGTVDGTKDRsDQHIQLQLAAESiGEVYIKSTeTGQFLAMDTDGLLYGSQTPnEECLFLERL 89  cattle
1FMM_S      2 KPKLLYCSNgGYFLRIFPDGKVDGTRDRsDPYIQLQFYAESvGEVYIKSLeTGQYLAMDSDGQLYASQSPsEECLFLERL 81  eastern newt
2NTD_A     16 KPKLLYCSNgGHFLRILPDGTVDGTRDRsDQHIQLQLSAESvGEVYIKSTeTGQYLAMDTDGLLYGSQTPnEECLFLERL 95  human
3FJ8_A     16 KPKLLYCSNgGHFLRILPDGTVDGTRDRsDQHIQLQLSAESvGEVYIKSTeTGQYLAMDTDGLLYGSQTPnEECLFLERL 95  human
4QBC_A     16 KPKLLYCSNgGHFLRILPDGTVDGTRDRsDQHIQLQLSAESvGEVYIKSTeTGQYLAMDTDGLLYGSQTPnEECLFLERL 95  human
4QC4_A     16 KPKLLYCSNgGHFLRILPDGTVDGTRDRsDQHIQLQLSAESvGEVYIKSTeTGQYLAMDTDGLLYGSQTPnEECLFLERL 95  human
P19596     25 KPKLLYCSNgGHFLRILPDGKVDGTRDRsDQHIQLQLSAEDvGEVYIKSTaSGQYLAMDTNGLLYGSQLPgEECLFLERL 104 chicken
Q6GLR6     25 KPKLLYCNNgGYFLRILPEGVVDGTRDRnDLYITLKLSALSqGEVHIKTTeTGCYLAMDSSGQLYGTLTPnEECLFLETL 104 African clawed frog

Feature 1                          ####   #   # # ####        
1AXM_A     85 EENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPV 132 human
1AFC_A     90 EENHYNTYISKKHAEKHWFVGLKKNGRSKLGPRTHFGQKAILFLPLPV 137 cattle
1BAR_A     90 EENGYNTYISKKHAEKHWFVGLKKNGRSKLGPRTHFGQKAILFLPLPV 137 cattle
1FMM_S     82 EENNYNTYKSKVHADKDWFVGIKKNGKTKPGSRTHFGQKAILFLPLPV 129 eastern newt
2NTD_A     96 EENHYNTYISKKHAEKNWFVGLKKNGSVKRGPRTHYGQKAILFLCLPV 143 human
3FJ8_A     96 EENHYNTYISKKHAEKNWFVGLKKNGSIKRGPRTHYGQKAILFLPLPV 143 human
4QBC_A     96 EENHYNTYISKKHAEKNWFVGLKKNGSTKRGPRTHYGQKAILFLPLPV 143 human
4QC4_A     96 EENHYNTYISKKHAEKNWFVGLKKNGSSKRGPRTHYGQKAILFLPLPV 143 human
P19596    105 EENHYNTYISKKHADKNWFVGLKKNGNSKLGPRTHYGQKAILFLPLPV 152 chicken
Q6GLR6    105 EENHYNTYKSKKYADMNWFVGIKKNGASKKGSRTHYGQKAILFLPLPA 152 African clawed frog

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