Conserved Protein Domain Family
LAS2

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pfam15792: LAS2 
Lung adenoma susceptibility protein 2
LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.
Statistics
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PSSM-Id: 464872
Aligned: 23 rows
Threshold Bit Score: 59.0259
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017199679 163 SLNTEQNPN---LQESSTTMGKDNLVTPVI-----YTYKNGKQC--GRLKNPKLVNRTNKCISESSLSFSKKSSLKDSSE 232
2_pfamImport   1 SLDIEKNPN---FQEPFFSVRKDNLVTPLV-----YANINGKRTkcYD-KIELLILKAKRNLEHSTEELPTSMK-NDGSP 70 
XP_013213015 160 SSAIKKHLN---FQDSCTSM--------------------------GD-KIELLILKAKKNLDQCTEELPKSVE-KDDSP 208
XP_023351633 321 LVNCQQNCElgqFQYENIP----------------FSGQSKKPF--SDDKIELLILKAKRSLEHSPEGLSSTMK-NDVNP 381
XP_007657748 318 RLDPERNKKv--LTAGCICDCE---CDQFQsesvsFSRQSTQPF--SDDKIELLILKAQRTLEHSSEVMSNTAK-NEGSP 389
XP_009250664 327 ELVNEYKCD---FEHS-QCQCEN----PLL-----PGQSTKPFS--GD-KIELLILKAKRNLEQCTEELPKSMK-KDDSP 389
XP_024091868 161 SLDIEKNPN---FQGPYTPVGNDNFVTPVI-----CTNINGKQC--GD-KIELLILKAKRNLEQCTEELPKSMK-KDDSP 228
XP_007626922 162 SSDIKKKPN---FHIDSTPKSKDNVVTCDV-----YSNVNGKKC--GRPGTLKPVNRNNKRVLESSLSIPKESSFKDSSN 231
XP_023368165 328 ELVNEYKRD---FEHSPQCQCKN----PLL-----PGQSAEPFS--GD-KIQLLILKAKRNLEQCTGQSPQPMK-KDDSP 391
XP_016850727   1 ------------------------------------------mpllkdDDVDILLHKAWKTLESSAEELTSALK-NDGSP 37  green anole
XP_017199679 233 HSAEK 237
2_pfamImport  71 CSLDK 75 
XP_013213015 209 CSLDK 213
XP_023351633 382 CSLDK 386
XP_007657748 390 CSLDI 394
XP_009250664 390 CSLDK 394
XP_024091868 229 CSLDK 233
XP_007626922 232 YGPEM 236
XP_023368165 392 CSLDK 396
XP_016850727  38 CTVDV 42  green anole
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