1CDZ,3QVG,3PC6,3PC8


Conserved Protein Domain Family
BRCT_XRCC1_rpt2
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cd17707: BRCT_XRCC1_rpt2 
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins
XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain.
Links
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Statistics
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PSSM-Id: 349340
Aligned: 24 rows
Threshold Bit Score: 144.331
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:3QVG: The C-terminal BRCT domain of XRCC1 forms a homodimer, contacts at 4 A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              #    #  #   # #           
1CDZ_A         1 ELPDFFQGKHFFLYGEFpg-dERRKLIRYVTAFNGELEDYMsd-rVQFVITAQEWDpSFEEALMDNPSLAFVRPRWIYSC 78  human
3QVG_B        11 ELPDFFEGKHFFLYGEFpg-dERRRLIRYVTAFNGELEDRMne-rVQFVITAQEWDpNFEEALMENPSLAFVRPRWIYSC 88  house mouse
KFM74411     570 ELPNLFKSRHFYLYGDFtf-qMQHDLKRYITAYNGVIEDYMsd-tVKYVITESKWDkNFEEALNENEDLIFVKPQWIFKC 647 Stegodyphus mim...
XP_012557734 337 SLPDFFSGNCFFVYGDMds-kDRRYLKRCIIAYAGTVEEYMke-sVNYVITNSDWDdNFKQALAENSSLKFVRPKWIFKC 414 Hydra vulgaris
XP_003386033 462 NLADFFSDCVFLLYGDFss-sDMRLLTRYIRAYNGTIENYMsd-kVTHVITQSEWDeNFDQAKSENSSLVFVGPDWIFAC 539 Amphimedon quee...
ELT92521     555 DLPNFFDAKHFFFYGTLda-vEEKKLRRCIIAYGGEMDDYMca-eTNYVISNSAWDeNFDDAVNENANLAFVKPPWIFMC 632 Capitella teleta
XP_002108457 507 SLPDYFSGMRFLIYGDFsy-dERRILIRYLTAYDGHVEEYMge-kVNIVVTDNEWDeKFDQAVADFPNLTFLRSEWIYEC 584 Trichoplax adha...
CDS42490     479 PLPDYFSGRKFFIFSRDldvnEGKTVYRLIIAFGGIIEPHMst-dVEFVVSRAAWCdEFDEALEVSSSLTFVKPEWIYAC 557 Echinococcus mu...
XP_018018970 594 LLPDIFSGEHFFIHRSCh---DPADVKRYIIAFNGHVSDYMss-cVNFIVADAKWDkTFDEVTQENQEVRFVKPSWIWRC 669 Hyalella azteca
XP_009862072 401 SLPNYFDSLGFCLVGEFsa-aVERMLRRHVTVFGGNVHDSIedndVTHVVTQGGWNtELKKRLKSNPSLQFVRPEWVFKC 479 vase tunicate

Feature 1               # ## # ##
1CDZ_A        79 NEKQKLLPHQLYGVVP 94  human
3QVG_B        89 NEKQKLLPHQLYGVVP 104 house mouse
KFM74411     648 HEQGKLLPYQPYIVIP 663 Stegodyphus mimosarum
XP_012557734 415 HEKQKFLPCDPYLVLP 430 Hydra vulgaris
XP_003386033 540 HKEQAIVSCEQFAIHS 555 Amphimedon queenslandica
ELT92521     633 DEKQKIVPYQKFVIVP 648 Capitella teleta
XP_002108457 585 HNQRKRLPFQKYLITP 600 Trichoplax adhaerens
CDS42490     558 DRAGKMVPFQRYQIVG 573 Echinococcus multilocularis
XP_018018970 670 VDASSRAPLEPHLITS 685 Hyalella azteca
XP_009862072 480 SKSASLLPCAAYAVPR 495 vase tunicate

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