1NYS,5HLY


Conserved Protein Domain Family
TGF_beta_INHBA
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cd19404: TGF_beta_INHBA 
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.
Links
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Statistics
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PSSM-Id: 381674
Aligned: 8 rows
Threshold Bit Score: 220.566
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
polypeptidehomodimer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:1NYS; Homo sapiens INHBA in complex with activin receptor, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #            # #   #                                                  # 
1NYS_B         9 NICCKKQFFVSFKDIGWNDWIIAPsGYHANYCEGECPSHIAgtsgsslSFHSTVINHYRMRGHSPFaNLKSCCVPTKLRP 88  human
5HLY_A       276 NICCKKQFFVSFKDIGWNDWIIAPsGYHANYCEGECPSHIAgtsgsslSFHSTVINHYRXRGHSPFaNLKSCCVPTKLRP 355 human
P27092       317 NICCKKQFFVSFKDIGWSDWIIAPtGYHANYCEEECPSHIAgtsgsslSFHSTVINHYRMRGHSPFaNLKSCCVPTKLRP 396 chicken
P08476       319 NICCKKQFFVSFKDIGWNDWIIAPsGYHANYCEGECPSHIAgtsgsslSFHSTVINHYRMRGHSPFaNLKSCCVPTKLRP 398 human
XP_006012178 279 SICCKKQFYVNFKDIGWNDWIIAPsGYHANYCEGECPSHIAgtsgsslSFHSTVINHYRIRGYSPFaSIKSCCVPTKLRA 358 coelacanth
XP_007896296 187 NICCRKQFYVNFRDIGWSDWIIAPiGYYGNYCEGECPSHIAgtsgsslSFHSAVINHYRIRGYSPFnNIKSCCVPTKLRA 266 elephant shark
AAX68505     298 RVCCKRQFYVNFKDIGWSDWIIAPsGYHANYCEGDCPSHVAsitgsalSFHSTVINHYRMRGYSPFnNIKSCCVPTRLRA 377 zebrafish
BAA12693     306 SICCKKQFYVSFKDIGWSDWVIAPpGYTANYCEGDCPMYITgtsgsgpSFHAAVINQYRMRGYSPFtSVKSCCVPTKLRA 385 Japanese firebe...

Feature 1         ### #     # # #      #     
1NYS_B        89 MSMLYYDDGQNIIKKDIQNMIVEECGCS 116 human
5HLY_A       356 XSXLYYDDGQNIIKKDIQNXIVEECGCS 383 human
P27092       397 MSMLYYDDGQNIIKKDIQNMIVEECGCS 424 chicken
P08476       399 MSMLYYDDGQNIIKKDIQNMIVEECGCS 426 human
XP_006012178 359 MSMLYYDDEQNIVKKDISSMTVEECGCS 386 coelacanth
XP_007896296 267 MSMLYYDDEHNIVKKDIQNMIAEECGCS 294 elephant shark
AAX68505     378 MSMLYYNEEQKIIKKDIQNMIVDECGCS 405 zebrafish
BAA12693     386 MSMLYYDDGQNIIKKDIQNMVVEECGCS 413 Japanese firebelly newt

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