2RAW


Conserved Protein Domain Family
Nbl1_Borealin_N

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pfam10444: Nbl1_Borealin_N 
Nbl1 / Borealin N terminal
Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.
Statistics
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PSSM-Id: 463095
Aligned: 67 rows
Threshold Bit Score: 37.5396
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RAW_B         2 KLASFLKDFDRE-VEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFAL 58 
XP_011276378   8 EKNKLTTRFEKQ-AAERKQSLEEELQKLTKTFINKIERRSQRIPKKFMDLKIKDVLDV 64 
Q6CAD3        81 QRAQHTNRLGINtVTNRIERLKSQYQFAAQAVRAKIEIRKTRVPKRYWNKTLREVQAL 138 Yarrowia lipolytica
XP_011121874 182 EKDRLIENIRYE-VERRAKALRQRYTLQAEMLRQGIELRVGRIPYKMRNMKMGDLYDQ 238
XP_001938254  12 AKANMLANLQIE-IDSRTEKLRAQCDAQCASMQSRLERRVNRIPVVTRQTTLLQLLKA 68 
EMF17743      23 QKRALVDNLQLE-ITERALRLRTQYAAQAQGLRARLDLRVNRIPHALRKRNMQELMDE 79 
EON61948      38 QKQALIDNLQLE-ITERARKLRAQYALHAQSLRSRLEMRVNRIPQSLRSTNIMELIDK 94 
XP_007582062  19 QKQALMDNLQLE-ITDRARKLRSQYGLLAQGLRSRLEMRVNRIPTALRKTNIMDLVEK 75 
CCT62164      50 QKQAMIDNMQLE-ITERARRLRAQYNYMATTVRSRIEMRLNRVPMSMRNMKMGDLLQK 106
Q3E7Y6        13 LRSAILHRMQLE-LETTEKLIENIKEETLKKLNLLQQPDATSAPQS--KELIREVLEQ 67  Saccharomyces cerevisiae S288C
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