2Q2E


Conserved Protein Domain Family
COG1389

?
COG1389: COG1389 
DNA topoisomerase VI, subunit B [Replication, recombination and repair]
Statistics
?
PSSM-Id: 440999
Aligned: 72 rows
Threshold Bit Score: 588.721
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2Q2E_B         3 TPIAEELAK---KQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILPDILVQVERT------GPD- 72 
AFH42740       8 VDTMTENVE---SFRQLSPSEFFYRNKEIAGFSSPSRALYQTVREFVENSLDATEVHGILPNVVISISREds---sNPN- 80 
BAJ50675       4 VETSVERGEn-iVYRAISPSEFFYKNRDIAGFSSPARSLYMSIRELVENSLDAAEMGRILPEVLIELGEEd----sERG- 77 
AFU59896      11 AAQQKPLTKgkvRYDKKAESEFFVDNSALAGFTT-ERILYMAVRELIENSLDSCETGHILPKISLSLKMSd----qAND- 84 
WP_012123231   5 RVQSERGEE---RFKAIGPAEFFFRNIELTGFDNYTRAIFQTVKEMLDNSLDATETHGILPRITIVIERLn----eAKAs 77 
WP_048062719   1 ----myMSDv--AFESLTPAEWFRRNKEIAGFSSPSRAMYQTVRELIENALDATENHGILPSIKASIRYVd----kDKD- 69 
WP_012310094   1 ------MGEk-vKLEEISAADFFYRNRSLAGFDNPVRATYTIIRELVENSLDAVELAGRSPKVLIVMREEreggeeSLP- 72 
WP_013336987   1 ----mgTNDi-vKFEALSPAEFFRRNREIAGFSNPTRAVYQTIRELVENSLDATETFKILPSIKIYIDYAd----qSRN- 70 
WP_014026830   1 ------MDH---ELKQITVAEFLYKEKQLWGFENPARALYQTIREYVENALDATDLYGILPNVTVIIEQDe----kDKS- 66 
WP_020962614   1 ------MSE---KYRGLSPAEFFHRNKEIAGFSNPSRALYQTVRELVENSLDATETHGILPYIDVEVRLHe----dRPE- 66 
2Q2E_B        73 ---------------YVTVIIEDNGPGIVREQIPKVFAKLLYGSRFhALKQSRGQQGIGISAAVLYAQMTAGRHTKILSK 137
AFH42740      81 ---------------YFTVSVEDNGIGIPSNIIPDAFGRILYSSKY-KFRQTRGMYGLGAKMAILYGQITTGKPFEIYSS 144
BAJ50675      78 ---------------VYRLRVVDNGVGVPGDKIPSAFATVLYGSKY-GFKQSRGTFGLGGTMALLYGQITTNKPAKIMSS 141
AFU59896      85 ---------------LWTITCEDNGIGVPLDKVPVAVCSFLTSGKY-VEKQQRGLFGVGLKMIAAFSTKDTIHPLKVWSK 148
WP_012123231  78 keeeekkeikgskdgIYRITVDDNGIGVPQDKIPYAFGRMLYSSKY-VERQTRGTYGLGVKAAVLYAQKTTGEPATVISS 156
WP_048062719  70 ---------------LYSIYVEDNGIGIPEEEIPNVFGQIFYSSKY-KIKQHRGIFGLGAKMVVLYAQSTSGMPVRVTSS 133
WP_012310094  73 ---------------WYRIRVADNGIGMDPEEIPLAFGRVFVSSKY-RLIQSRGTFGLGGTMALLYGQITTNMPFKITSA 136
WP_013336987  71 ---------------WVSIYVEDNGIGIPGDEIPNVFGRVFYSSKY-RIKQHRGIFGLGAKMVVLYAQSTTNTPILVRSA 134
WP_014026830  67 ---------------ICTVTVEDNGIGIPPQKIAEALGKPLVTSKF-KIRQSRGQFGLGAKAVTVYALSTTGSPIEAYSS 130
WP_020962614  67 ---------------WVTLRVADNGIGIPAHEIPNVFGRVFYGSKY-VVRQTRGVFGLGVKMAVLYAQMTTGKPIYVKSS 130
2Q2E_B       138 TSPTAPAHYYELMINTSTNEPDILVDEVRDW-----FRPHGTQIELEMRAAYV-KG----RrQSIYEYLKATAIVNPHAR 207
AFH42740     145 TSRSNKIFYYKLSVDIRKNEPIVFEEGAWEKk----TSWHGTIAKVTIEGDWNkRT----R-DYISVYVKRTAIIAPYAD 215
BAJ50675     142 T-DGKTLHIYELMIDVVENRPRIISSEKKPSp----GGWRGTSVEFSLEADYP-GA----R-AKILDYIKHTAIVNPHAS 210
AFU59896     149 SHEEGSEYYFELRTDISTNKPIVLAKRPAKGeesriVGDSGFRVEAVLHAKLSpITrnniK-AKINEYISQTSIVNPYAI 227
WP_012123231 157 PIKDKMTYRFKVSTNISTNEPDVKERGSWTKs----GDWHGTRVSVIIEGNWR-RA----R-SKVVEYVRRTAIVAPYAD 226
WP_048062719 134 MKGSQYIYTYEISIDTVKNKPVIHSHVRVENk----YGWHGTAVKVVLEGNWQ-YA----K-SRIEEYFTRTAMITPYAE 203
WP_012310094 137 R-EGEPAYELTMMIDIRKNEPIILDRKIKg-----vSRRSFTIVESTFEGNYP-RA----K-RKIIDYLQQTAIVVPYIS 204
WP_013336987 135 PLKSDVIYEYQLMIDITKNEPVIVSQRTLENk----YAWHGTAIKVVLEGDWP-KA----K-RRVEEYLRRTAMVAPYAE 204
WP_014026830 131 PLDSERVYYVKFSIDLSTNEPAIYALGSWRKs----TKWHGTRIRARIRCNWS-YA----R-SRILKYFEMLAIVTPYAD 200
WP_020962614 131 TRDSDVVGEYLLYIDISRNIPHVQKMRIKKKn----KNWHGTIVRLTLEGAWL-QS----K-KRIEDYIRRTALISPYAT 200
2Q2E_B       208 ITLIDP------------DGN-EEVFERATDKMPEPAEEILPHPEGIELGTLMKMLHY--TERQKLAPFLRYSFCKIGLL 272
AFH42740     216 ITLIMPkfngeqegngeeESE-IVCYKRVTDKLPVPPKETKPHPLGIDLEMLKMSISE--SKNKTIKDFLMKNFQRIGEK 292
BAJ50675     211 LTFIDS------------KGR-LYHYPRMVEKVPEPPRETLPHPVGVDVEMMSRMLLE--TKARNLLTFLTTSFQKIGPK 275
AFU59896     228 IEYETD------------EGK--VTFDRRTEVMPQPAKEVLPHPADMDLQTLKKAIMNfmNNKTTLQGVLAASFQKMSSE 293
WP_012123231 227 ITLITP------------DGT-LIRYPRRTKEMPKPPKEVKPHPLGIDIETMKRIAQL--TTAKTLLQMLTTEFQAVGAK 291
WP_048062719 204 IILIEP------------NNE-VLRFNRITTIMPKPPVEGLPHPSSIDLESLKQLISR--NSDIPLIDFLKENFDGIGDE 268
WP_012310094 205 IAFMDP------------EGH-LYIFPRSTEKIPPRPKEALFHPKGVDLELLQRLLSS--TRTRSLESFLMTHFQRVGKK 269
WP_013336987 205 FVLRGP------------DEDdAIKIPRITTKMPDPPEEGLPHPKSVDVELIKQLIQR--DPSMPLLEFLVENFDGVGET 270
WP_014026830 201 IVFIEP------------DGT-IHHYPRIVEKMPRPPKEVKPHPASLEKGELQMLLKR--TTARTIKEFLISTFQRVGEK 265
WP_020962614 201 IRYRSP------------DGE--LLFERVSKELPEPPQIGKYHPKGVDIEILKDLIRRsnNNDMTLAGFLEKYFEGVGEK 266
2Q2E_B       273 TAEEICKAAGLDPEIDPHALGRHEARKLIEAFEKV----KIMAPPTDCLSPIGEDLIYRGLEK----------------- 331
AFH42740     293 KAEEILKIAGIDFDRNPKNLNDKEIEALYKSIKSV----DFISPSPDPLSPIGEELIKIGLKQ----------------- 351
BAJ50675     276 TAKEVLELAGLKPETSPRKLSHEQVTALVDAFKRYd---KFRPPDPTPLSPVGKDFLEAGIRR----------------- 335
AFU59896     294 KAKDIIAKAGLEN-KPADKYSENELIEIVKVCKHM----PFQQANTDHLSPIGEEILTTGMTSeytivttkevvpaaegs 368
WP_012123231 292 TAKAILSMAGLEPDLEPKKLTEEQIKALVNAMKEYgttkRYKAPSKEALSPIGEKLIKIGLKS----------------- 354
WP_048062719 269 TVREFMKTVGIRASKHVKRLSESELRLLAEKMRQFn---GWRRPRADWLSPIGEKILANGILH----------------- 328
WP_012310094 270 TASEVLKIAGLPPDKRPSDLKDEDIRRLYEALRSYk---EFLPPDPSVLSPLGEELFESGIKK----------------- 329
WP_013336987 271 IAKTFLDFVGLPPDMPVGKLVNDELVNFVTKMREFn---GWRRPRADWLSPIGEDILAEGVKF----------------- 330
WP_014026830 266 SALNVLKLAGIDPSKPPQSLTDEEIERLHKALRSY----KFPAPSSEALAPIGAELIEAGLKA----------------- 324
WP_020962614 267 IAQEFLTWAGFQPDTKVKELKLADLEKLATAMKNFp---KWRRPRPLTLSPLGPELLKKGVKS----------------- 326
2Q2E_B       332 -------------ETTVDFIATSTRKPAVYS-GNPFVVEVGMAYGGNLPKE--------------EKISIMRFANRVPLL 383
AFH42740     352 -------------VLNPEFVDAITRKPKSYG-GHPFIVEAGIAYGGKLSENldeiardsikgqsgPFIALLRYANKIPLL 417
BAJ50675     336 -------------IFNPDFVYVVQREPSSYS-GHPFIVEAAVAYGGTIPVT--------------ETIMLFRFANKIPLL 387
AFU59896     369 gapevqkpqitvkVLKPS-LTAYASRTCVIN-NRPTIVECGIAYGGDI-----------------PSFKLYRFANKIPLL 429
WP_012123231 355 -------------MLNPEFVTAVSRRPSSYS-GHPFVVEVGIAYGGEIPPS--------------DAPVLLRYANKTPLL 406
WP_048062719 329 -------------VLKPEAVFVTTRKPSSYS-GHPFIVEAAIAWGGSIMPV--------------DKPILYRYANKVPLL 380
WP_012310094 330 -------------ELQPEFVKAIQRPPSVYE-AHPFIVEVAIAYGGLIKPT--------------GDIQLYRYANKIPLL 381
WP_013336987 331 -------------ILRPEVVFTVTRKPSSYM-GNPFIVEAALAWGGSIEPS--------------DKPIIYRFANKVPLI 382
WP_014026830 325 -------------ILKPEFVVAVTRKPRMHSgGHPFIVEVGIAYGGAIEPR--------------EQPLLLRYANRIPLI 377
WP_020962614 327 -------------ILKPEFATAVIRPPSSYG-GHAFIVEAAIAYGGEIPPQ--------------DNVLLLRFANKMPLL 378
2Q2E_B       384 YQQGGCVTTHAV--EDIKWKQ-YGLNQPg-------------gGIPVGPVILLIHVASINVPFTSESKDAIADIPVIKEE 447
AFH42740     418 YDEKADLIWSVVnpDDFNWKNtYKLD-------------------PSDIVVVLVHIASTKVPYKGVGKESIAQVEEIRKE 478
BAJ50675     388 YDERADVAWKVVe-EKIDWSN-YKVPK------------------PA-PLAVFTSICSTKVPYKTVGKEAIADRPEIERE 446
AFU59896     430 YDEGSDVAREVV--SEVEINK-MGITKKeakeqfanpevksdrAVELLPLHIFFHICSTKIPYKTAGKESIASEGELKKY 506
WP_012123231 407 YNERNDVSWKVV--SELNWKN-YEVSF------------------PA-PLVVLVHVASTKVPFKDVSKDTIADVPEIEAE 464
WP_048062719 381 QDEGSDVIRHVI--DEVDWSQ-YKVKF------------------PA-PLAVVVHVCSTKIPYASAGKEAIADVPEIEKE 438
WP_012310094 382 YDASSDVSYQVI--KKIDWSI-YGIKNP-----------------EDEPIAFFIHIVSTKVPFKTVGKEFIANVPEVARE 441
WP_013336987 383 YDEGNDVVRKIV--DEIDWTQ-YKVKF------------------PA-SLAIVVHICSTKIPYASAGKEAIAEVPEIESE 440
WP_014026830 378 YDEKADVAWKVL--EEFNWKH-YGVNF------------------PA-PLVVLTHICSTKIPWKVGSKEAVAEREEIKEE 435
WP_020962614 379 YDEGVDVSRKIV--DSIDWSI-YKIKF------------------PA-PVAVVTHVCSTKIPFKGVGKEAIADVPELEHE 436
2Q2E_B       448 IDLAIKEVARKLKHYLSKQSNLKKRREKEIIITKVLPKLAAKVAHVLEKDVP--------DINPVVAKIMGNLLVH--RV 517
AFH42740     479 VEAAVQELARRLRKYIVKKRKREEAEEKFRIFLKYIPEVAQNLAVFYDGVSPeerkkiaqELESTLKAIAEKKVKIieEV 558
BAJ50675     447 LTMALRECGRNLKLYLSRIEKREAAAKRLSLYTKYLPMIAEFAAKTAGTSKP--------NIKPLLKKLGITETTAa-EK 517
AFU59896     507 MKYCLSELYRKVSAQIRKELRMKEAQSRLNLYKYYIPLIVSAISESIKVDPV--------KLEQAFTELAEKHVRIe-QL 577
WP_012123231 465 IRLALQEAARRLKRFIIKKRKEEELAEKVITFLKYVPEIARSLKVLSVDPETrkptvseeEIEEKLKKLIAKKLGVpeDK 544
WP_048062719 439 VRLAVREVARKLKVYLARKEKEQELLTKYAILRLYTDEVSSALSFVSGVDEN--------VIKGKLEELIKRKLGLdiRA 510
WP_012310094 442 IELGLRGCARELRIYLGRKRRKEMLLKRYELFRMYYELISWTLEEIIGERPP---------IENLIEKIKGSAGDEdeRE 512
WP_013336987 441 VRNAVREVARKLRLYITRKEKEQELLMKYAIFSMYGEEVANALSYVSKADLD--------ELRGSINALIREKLKI--RS 510
WP_014026830 436 LHLALQEAARKLRHYLIEKRREEELREKISTFLRYIPEVAQSIATILGEDGVtp-----dKVQRLLLDTLRRRMKGkeLQ 510
WP_020962614 437 LEIAIRDVARRLRIYLSKLEKMYEVKRKEVTIRKYMGEVSSSLAYVLNMDPN--------SISSLLEELLKKELEKkeVT 508
2Q2E_B       518 IKNngdgtvDVAIKVKNFGTSA 539
AFH42740     559 KEE------------------- 561
BAJ50675     518 YAE------------------- 520
AFU59896     578 VNNtpsstttaekedkitteri 599
WP_012123231 545 LPE----------VVIGIE--- 553
WP_048062719 511 GPP------AITSEVGNVAVA- 525
WP_012310094     ----------------------    
WP_013336987 511 LEE------LLTNTANNAENGS 526
WP_014026830 511 VFE---------QQVKNLSKVK 523
WP_020962614 509 VNA------------------- 511
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap