1KQQ,1C20


Conserved Protein Domain Family
ARID_Dri-like
?
cd16881: ARID_Dri-like 
Click on image for an interactive view with Cn3D
ARID/BRIGHT DNA binding domain of dead ringer (Dri) from Drosophila melanogaster and similar proteins
Dri, also termed retained (retn), is a nuclear protein with a sequence-specific DNA-binding domain termed AT-rich DNA-interacting domain (ARID, also known as BRIGHT). It is a founding member of the ARID family. Sequence comparison shows that DRI belongs to the "extended" or e-ARID subfamily, which exhibits an extended region of similarity either side of the ARID. Dri plays an important role in embryogenesis. It functions as an essential transcription factor involved in aspects of dorsal/ventral and anterior/posterior axis patterning, as well as myogenesis and hindgut development.
Links
?
Statistics
?
PSSM-Id: 350645
Aligned: 10 rows
Threshold Bit Score: 257.132
Created: 15-Jan-2015
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
DNA binding
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1KQQ; Drosophila melanogaster Dead Ringer binds DNA through its ARID domain, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #######                         # ##  # 
1KQQ_A         6 FEEQFKQ-VRQLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIA-RGGLVDVINKKLWQEIIK 83  fruit fly
1C20_A         4 FEEQFKQ-VRQLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIA-RGGLVDVINKKLWQEIIK 81  fruit fly
JAB58473     203 FEEQFKQ-VRQLYEINDDPKRKEFLDDLFLFMQKRGTPINRLPIMAKSVLDLYELYNLVIA-RGGLVDVINKKLWQEIIK 280 Corethrella app...
NP_001286775  20 ERDSDLG-DDLLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIA-RGGLVDVINKKLWQEIIK 97  Drosophila mela...
XP_013414420 166 HWTFEEQ-FKQLYELSDDSKRKEFLDELFDYMQKRGTPVNRIPIMAKQTLDLYELFRLVVS-KGGLVEVINKKLWREITK 243 Lingula anatina
CCD77794      36 QWTFEEQ-FKQLYVISDDPKRKEFLDELFVYMQRRGTPVNRIPIMAKQVLDLYELFQLVVA-RGGLVEVINKKLWREITK 113 Schistosoma man...
EKC30576     170 FEEQFKQaFSQLYELSDDPKRKEFLDDLFQFMQKRGTPVNRIPIMAKQTLDLYELSRLLVVsKGGLVEVINKKLWREITK 249 Pacific oyster
XP_006815896 121 EWTFEEQ-FKQLYELSDDPKRKEFLDNLFSYMQKRGTPVNRIPIMAKQTLDLYELFKLVVS-KGGLVEVINKKLWREITK 198 Saccoglossus ko...
ELU13411      10 FKQCFSFfVLQLYELSDEPKRREFLDDLFSFMQKRGTPVNRIPIMAKQTLDLYELFRLVVS-KGGLVEVINKKLWREITK 88  Capitella teleta
XP_008196290 139 TWSFEEQ-FKQLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIA-RGGLVDVINKKLWQEIIK 216 Tribolium casta...

Feature 1              #### ### #                             ##
1KQQ_A        84 GLHLPSSITSAALTLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNR 130 fruit fly
1C20_A        82 GLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNR 128 fruit fly
JAB58473     281 GLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSSPSELQAAIDGNR 327 Corethrella appendiculata
NP_001286775  98 GLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNR 144 Drosophila melanogaster
XP_013414420 244 GLNLPSSITSAAFTLRTQYMKYLYPFECEKLKLSTPSELQAAIDGNR 290 Lingula anatina
CCD77794     114 GLNLPSSITSAAFTLRTQYMKYLYPYECETLGLSSPNELQAAIDGNR 160 Schistosoma mansoni
EKC30576     250 GLNLPSSITSAAFTLRTQYMKYLYPYECEKLKLSTPQELQAAIDGNR 296 Pacific oyster
XP_006815896 199 GLSLPSSITSAAFTLRTQYMKYLYPYECEKLKMSSPAELQAAIDGNR 245 Saccoglossus kowalevskii
ELU13411      89 GLNLPSSITSAAFTLRTQYMKYLYPYECEKLKLSNPSELQSAIDGNR 135 Capitella teleta
XP_008196290 217 GLHLPSSITSAAFTLRTQYMKYLYPYECEKRRLSTPAELQAAIDGNR 263 Tribolium castaneum

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap