6TC0


Conserved Protein Domain Family
MMS19_C

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pfam12460: MMS19_C 
RNAPII transcription regulator C-terminal
MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.
Statistics
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PSSM-Id: 463594
Aligned: 85 rows
Threshold Bit Score: 208.268
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TC0_C        560 CLQALSAVSTHPSIVKETLPLLLQHLCQANKG------------------NMVteSSEVVA--VCQSLQQVAEk-----c 614 
EPB91135      557 TLATINKLCVPPAIYEATEQELLTKFLYICSH------------------NQD--KRYALE--IISTLLTLVRtk----d 610 
EPB86737      542 TLDEIQVLGAHPAVFKIIIQSILEKVDFACRHi----------------gKNN--INFVHD--MALTLLKIYKa------ 595 
3_pfamImport    1 VLLAITELCHESCIFQATIFLLIDLCVEKIDSkeggirfremdgdiarqrRVD--C-------LLDAVAKIVEinaadqt 71  
NP_001334591  537 CVAALASVSSQPSVVQESSPVLLQVLTSAHTG------------------CCG--FSVEEViaVCISLQRIAVh-----a 591 
XP_023197233  586 CLSALAAVSVRASVVMESAPILLDVLGSAHAD------------------PDR--FSVDEVvcACLSLQRIAEr-----v 640 
Q0V9L1        547 CLEALAAVSTHQSILKETVPILLDYIGRVHNG------------------EGE--TNAENVvsICRSLHRVAVq-----c 601  tropical claw...
XP_004343013  537 LWVILTEISNTPPLLRRTAPLFLNQLQTLLASavampmdtsttsspsaaaSSS--PEQVEFevVLESVANIVAkga-sqq 613 
XP_002588594  550 VLNTLAAVSTHPTIVRCTIPKLLSHLQALIES------------------CPD--QATQEAiaTLDCVYKVVEk-----t 604 
EDO37103      429 MLNTLSAVCTEEGVVRHVVPIILDHGEYLVTGkd---------------lERG--VLHGKIseTLKCLNSIVKgt----l 487 
6TC0_C        615 QQDPESYWYFHK-TAVPCLFAL--AVQASmpEKESs-----VLRkvllEDEVLAALASVIGTATTHLSPE-LAAQSVTCI 685 
EPB91135      611 SDKQPDIKLCSE-TLLPKLFTS--VISAVmdETADpt--qvIIL----SDEVSEIINLIILAVVKNLGTS-YQQEYATQA 680 
EPB86737      596 ASKDCEIVVYGRnALLPTVLIE--CMKSVsgNEGN------WYL----DDTLIEMFAMIAAITTRLSSSS-EQQTSINDM 662 
3_pfamImport   72 SMEFCAQASLTN-SVIFRLLTA--VETSAayATSFadgeqcGLV----DDAKLGACIRIFRAVMQNVSAT-TQQRLVDAV 143 
NP_001334591  592 RDNEAIGQFFHD-IIIPRLLGL--TLQAAlqSKDSgh--isPLT----DEAVLSAIVPVISTACAALKPE-SASRMAAQA 661 
XP_023197233  641 QDGEDTSRCFHD-VIVPRLLSL--ALQAAlqNDGSsgr-rsPLV----EEEVLSSMVPVISTAFSRLQT--FAEQTASRA 710 
Q0V9L1        602 QLDSEALQFYHE-IVLPSLLSL--TVQAAtqDSGTsc---nVLL----RDDVLTAMVPVITAACTHLTPE-LASKSVSQV 670  tropical claw...
XP_004343013  614 QEVALRPSTLAE-TILLPVLSLafSLSAEpgTLGGv-----VST----NQSVVETLARIVRNIVCAASVQdCSSQLSTAV 683 
XP_002588594  605 VINDANVEYFVD-TIVLNLMSM--ALSAAvnTSDEn-----LLH----DTSLLEIVAKVLRAVARSLPNS-TGKGIVNST 671 
EDO37103      488 QSSTVEPNYYTE-VVIYRIIDL--CTQSAlqESPDc-----PMA----TPEALALVCSIVRQVISHLAVN-EAEDVLHII 554 
6TC0_C        686 VPLFLdgntsflpenSFPDqFQPFQDGssg--------------qrrLVALLTAFVCSLPRNvEI-P--QLNRLMRELLK 748 
EPB91135      681 FRYFKekdld-tlglKATPnFCPLSAQaska-------------qaaCTQLFATVVASLRKNaTV-PiqSNESFLDNIVS 745 
EPB86737      663 FKLFV------------QGdVSPLDQNiqidslpifghitstssaidITLLFTAIISNCCKTvQL-PipSLSGFMTNLIQ 729 
3_pfamImport  144 VPAFL--------------------RThsskp-----------asvqLVPLFSAVINSAAREvTL-P--DTSLVINRLLE 189 
NP_001334591  662 VSLFLdgdtsflpenAFPSqIQPLQSQadsr------------gpsqLVCLLMACVCSLPRSvEI-P--DMDRLLVQLED 726 
XP_023197233  711 VSLFLdgdvsflpdnSFPPrVQLLQQQedssw-----------cqtqLVCLLMACVCSLPRSvAL-S--QEERLLSELEE 776 
Q0V9L1        671 VALFLdgdvslfsenNLPSnFQPFQVNgpte------------lqnhLVSLLMAFVCSLPRNvEI-P--HLRRLLQHLLS 735  tropical claw...
XP_004343013  684 QTAFAal------tdPTTSpIRSVDVNaat---------------srKILVASAVLCCGPRElVLsLqsDFAAMLPKITL 742 
XP_002588594  672 VQAFLqgnla-aislNTSAsFEPLDVSspwq-------------qtqTVQLLSAIVCSVARNvDI-P--SISELAQKLLT 734 
EDO37103      555 VSNFIegkt--plsaRAEQkFAPLEPSspwq-------------qsqLVTVLMAAVCSARREvRI-P--RQKELVPRLQV 616 
6TC0_C        749 q--SCGHSC-PFS------------STAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLASESsrd------------ 801 
EPB91135      746 ---EALKSThEKQ------------ILAFSRIIASIINKWKDDDSFQAYLDVLKSRLEQLVLAKSqa------------- 797 
EPB86737      730 ---TATQTPsEMR------------KLALSKIAASIINKWLNDELLSHVKNLVSESILPTLETATdtdn---------kr 785 
3_pfamImport  190 laqSGGAATiPETvphrlqsvyteaAQSAAKSLASIVNKMPDGA-------ELDALVDSLLSQKLavvisdstetfgvrv 262 
NP_001334591  727 ---LSCTSPhLFS------------YTFASKCIAGLVNKRPAGAALNAVLDRVLKRVSLELEETSsthr----------t 781 
XP_023197233  777 ---LSCSCRhPFS------------YTSAAKCFAGLVNKKPQGPSLDRLIQGVIKRVSSELDRPSsplr----------t 831 
Q0V9L1        736 ---LSLSGCsPFA------------YSSASKCFAGLINKCPQGDLLDDILQVTAQRIDVGLVDEPsrt------------ 788  tropical claw...
XP_004343013  743 ---LALHSPdADT------------RRYCCMMAGAIINHLEDQDLSKHVETALLPQLEQLLRAACtaapataa-qdqqqr 806 
XP_002588594  735 ---LSCASDhEPT------------SLAAAKSLSGVVNKWDQGEQLQTFLQETRDCLEQILSKTEdeka---------rc 790 
EDO37103      617 ---LASGCNhRKT------------TVAASKCLGGIINKMAQGDDLTADLHSLKGQLQNHMDGNEeqr-----------w 670 
6TC0_C        802 qaFTLLLWVTKALVLRYHPLSACLTTRLMG-------LL----SDPELGCA-----------------AADGFSLLMSDC 853 
EPB91135      798 -aLSIYIWLAKALVTRAHKKSVDMIDFLIS-------LI----PDAVVGKH-----------------ASSGFDILVGDD 848 
EPB86737      786 stFVILVWIIKALIIRGHRYGFELLDSVIK-------QC----GSPELGKY-----------------AADSFITLLHQD 837 
3_pfamImport  263 aaLKIYVWVAKALVIRGHKVHAPVCLRFLC-------NFltpgNQRKHGDVnmdqegnglefsamrmeVAKAFKLLVSEY 335 
NP_001334591  782 qaFTLLIWVAKALLLRYHPLSTALTDKLFS-------LL----SDSALGSL-----------------VADGFCVLMNDS 833 
XP_023197233  832 qaFTLLIWVAKALLLRYHPLFSALTDKLFT-------LL----DDALLGPM-----------------AADSFSLLMSDS 883 
Q0V9L1        789 raITLLVWVTKALVLRYHPLSGQLTNKMIG-------LL----SDKQLGPS-----------------VANMFSLLVSDS 840  tropical claw...
XP_004343013  807 aaLALWIWITKALFIRGHALGDRMVSLLLTdcvraplLAdvaaAPSSFAQQ-----------------AAESMHTILTDS 869 
XP_002588594  791 raVAVLVWLTKALVIRGHPSGSQFTKTLMA-------LF----EDEAIGRR-----------------AAEGFYVILSDS 842 
EDO37103      671 raVITWLWLTRALVTRSHPMAQEFVQKVLH-------LL----DDVSVGRV-----------------AADGFYVIVSDC 722 
6TC0_C        854 TdVLTRAGHADVRIMFRQRFFTDNVPALVQGFHAA-PQDv--KPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCP 930 
EPB91135      849 AlCLNKQCFANISFLYKQKFMTFALPKLLKNFNAStEDE---KLNFLIAIAYLLKNVPRSILVDELPPLVPLLIESMSFP 925 
EPB86737      838 ElILNKSSHAIVSILFKQRVFTHCFRKLMDGAESVdVRQpelQVNYLLALIHVLQNIPSQVATNELHRLMLPIIVALSSH 917 
3_pfamImport  336 PdVLNRKCGAYITFLYKQRMFDLVFPLLFPFVRAHaDKEi--GVPALVAFAQVIAHSPKAVYLSHLAQIFPLIVRALNTD 413 
NP_001334591  834 PdVLNRDCHADVRIMYRQRFFTENSSKLVQGFNSAeQAK---KSCYLKALSHIVNNLPREVQLTELPALLPLLLEALSCV 910 
XP_023197233  884 AdVLNRGCHADVRIMYRQRFFSENSAKLVQGFNAApQEK---KANYLKALSNIVNKLPKQVQVSELPALLSLLLEALTCP 960 
Q0V9L1        841 PdIINKACHADIRIMFRQRFFTENVPKLVQGFNSAnRDD---KPNYLKALSHVLNALPKQVLMPELPSLLSLLLEALSCP 917  tropical claw...
XP_004343013  870 EeVLSKRTRANFRIMYKQRLFTSKSALIVQGYAATdDEH---KQFYLTALSHMLQNVPKQVLLTELPSLLPLLFQSLSHA 946 
XP_002588594  843 PdVLSKESHANIRLMYKQRFFMENLPALVDGFNQAdDGR---KQSFLCAVSHLLTFIPRQVLLGALPPLVPLLVQSLLGE 919 
EDO37103      723 DdVMNQAMHADIKMMYKQRFFMETLPLLLKGFHDTrPEC---KYLYLCALSHLLQWIPKQVLLTEIPTLMPMLIQALSRD 799 
6TC0_C        931 DSVVQLSTLSCLQPLLLeAPQIMSL--HVDTLVTKFLNLS--SSYSMAvrIAALQCMHALT 987 
EPB91135      926 DTVLKLSTLDLFQFSLQeATDIMAK--HIITLLPAFTSLIgpAEKSMKvrISALKCIQLIS 984 
EPB86737      918 DSNLIKSTLTVAQDIVPnAQDLVVQ--HLGSFIHALLRLT--RFHSANvrIIALECLTSIA 974 
3_pfamImport  414 DRELGSAAIQTFKPLLL--DSVESSkpFLKDVFPGLLKQAq-FGSGAKdrYAALECLAKLA 471 
NP_001334591  911 DQGVQLSTLSCLQPVLLeSPAALNT--QLEALFTRLLALT--TSPAMKvrMASLRCVHALS 967 
XP_023197233  961 DEGVQLSTLSCLQPVLInPPQVLVL--QLEALVSRLLALI--GSPAMKirMASIRCVLALS 1017
Q0V9L1        918 DKVVQLSTLTCLEPLLQeAPETLKV--HIDGLISKLVSLT--LSPAMAvrITALKCILALT 974  tropical clawed frog
XP_004343013  947 NVGLRLSTINSVYLLLFdAPALLAS--HTPTLIKHMMALSt-SPDSMKlrIAALQCLGLMA 1004
XP_002588594  920 DPSLQVSTLEMFSSLVQeAPQVISK--NIDALIPQLLELSk-NGPTMKvrMAALKSVGSMT 977 
EDO37103      800 EPSLLLSTLQTLYSLVFdAPEVISR--QVTSLIPNFLELAk-CKASMKvrMEAIKCLGAMT 857 
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