Conserved Protein Domain Family
AMPD

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cd01319: AMPD 
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Statistics
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PSSM-Id: 238644
Aligned: 11 rows
Threshold Bit Score: 838.947
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the adenosine deaminase family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
NP_494973  256 FLNDTEKLTAMIVDGPL-KSFCFRRLSYLENKFQLHVLL-NELRELHEQKGVS--------------------------- 306  Caenorhabditis e...
EAA19931    97 EYLEAIQEIMTTAQDPAcKSFCYQRLKYLEQKFDFHIMF-NGPLELKETANIK--------------------------- 148  Plasmodium yoeli...
P50998     271 YYIDLEFLLSASSDGPS-KSFSFRRLQYLEGRWNMYMLL-NEYQELADTKKVP--------------------------- 321  fission yeast
EAA36130   381 YYLDLEAILSVSSDGPS-KSFAFRRLQYLEKRFDLYVLL-EGYDETADCKKVP--------------------------- 431  Neurospora crassa
P15274     299 YYLDLEKMISISSDGPA-KSFAYRRLQYLEARWNLYYLL-NEYQETSVSKRNP--------------------------- 349  baker's yeast
NP_910462  304 FFTDMHYILRVLAAGDI-RTVCYKRLNLLEQKFNLHLMV-NADRELLAQKAAP--------------------------- 354  Japanese rice
AAF65407   111 YYKDINNLMMLSSYGPA-KTFTFKRLQLLESKFNMHTLL-NDSLELFQQKTAP--------------------------- 161  Dictyostelium di...
NP_572931  193 FVNDMQVMCNMIADGPL-KSFCYRRLCYLSSKYQMHVLL-NELRELAAQKAVP--------------------------- 243  fruit fly
P23109     240 FLDDMNFLLALIAQGPV-KTYTHRRLKFLSSKFQVHQML-NEMDELKELKNNP--------------------------- 290  human
AAH44154   266 FAIDLSHVLAMIADGPT-KTYCHRRLNFLTSKFQLHEML-NEMAELKELKCVP--------------------------- 316  zebrafish
CAC14614  1004 FQKDTRMLRRLASADPTvAKYASKRLDMLESKYRLHAALtNDDEEDYTITTATataaenaegdsteararaaptsrrcvv 1083 Leishmania major
Feature 1                     # #                                                              
NP_494973  307 ---HRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTea--dtVVLNNNGTKVTMKEVFK------------------- 362  Caenorhabditis e...
EAA19931   149 ---HRDFYNIRKVDAHVHHSACMQQKSLLRFIREKYNTepd-tiVYVNENGKKIKLKELFDd------------------ 206  Plasmodium yoeli...
P50998     322 ---HRDFYNVRKVDTHVHHSALANQKHLLRFIKAKLRKcp--neKVIWRDGKFLTLQEVFD------------------- 377  fission yeast
EAA36130   432 ---HRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKIKKyp--deIVLYRDGKYLTLAEVFE------------------- 487  Neurospora crassa
P15274     350 ---HRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHsk--deKVIFRDGKLLTLDEVFR------------------- 405  baker's yeast
NP_910462  355 ---HRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKep--deVVIFRDGTYLTLKEVFE------------------- 410  Japanese rice
AAF65407   162 ---HRDFYNVRKVDTHVHHSSSMNQKHLLKFIKRKLKEnp--neIVIFRDDKYLTLAEVFK------------------- 217  Dictyostelium di...
NP_572931  244 ---HRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNna--neVVTVTNGQQMTLAQVFQ------------------- 299  fruit fly
P23109     291 ---HRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIda--drVVYSTKEKNLTLKELFA------------------- 346  human
AAH44154   317 ---HRDFYNVRKVDTHIHAAACMNQKHLLKFIQDSYQTea--drVVLEKGGKKFTLKQVFE------------------- 372  zebrafish
CAC14614  1084 qpaCGDAHNCVKVDVHCHMASGMTAKSLLQFMQRKIRDhpddvvGVDSKTGAPITLVEFFDevlgeqlkpkpsavaqgdn 1163 Leishmania major
Feature 1                                                                                      
NP_494973  363 ----------------------------KMGIDAYDLSVDmLDVHADRNTFHrfdkfNTKYNPVGESTLREIFIKTDNYV 414  Caenorhabditis e...
EAA19931   207 ----------------------------ELKFSAHQATVDnLDVHALGNCFHrfdlfNEKYNPFGQKLLRDIFLKTDNYI 258  Plasmodium yoeli...
P50998     378 ----------------------------SLKLTSYDLSIDtLDMHAHTDTFHrfdkfNLKYNPIGESRLRTIFLKTDNDI 429  fission yeast
EAA36130   488 ----------------------------SLNLTAYDLSIDtLDMHAHTDSFHrfdkfNLKYNPIGESRLRTIFLKTDNFI 539  Neurospora crassa
P15274     406 ----------------------------SLHLTGYDLSIDtLDMHAHKDTFHrfdkfNLKYNPIGESRLREIFLKTNNYI 457  baker's yeast
NP_910462  411 ----------------------------SLDLTGYDLNVDlLDVHADKSTFHrfdkfNLKYNPCGQSRLREIFLKQDNLI 462  Japanese rice
AAF65407   218 ----------------------------SLNLDVDELSVDtLDVHADNNTFHrfdkfNLKYNPCGQSRLREIFLKTDNLI 269  Dictyostelium di...
NP_572931  300 ----------------------------SMNLTTYDLTVDmLDVHADRNTFHrfdkfNSKYNPIGESRLREVFLKTDNYL 351  fruit fly
P23109     347 ----------------------------KLKMHPYDLTVDsLDVHAGRQTFQrfdkfNDKYNPVGASELRDLYLKTDNYI 398  human
AAH44154   373 ----------------------------NLKMDPYDLTVDsLDVHAGRQTFHrfdkfNSKYNPVGANELREIYLKTDNYI 424  zebrafish
CAC14614  1164 stavrraapvfaaegdevvaaasakaarVAHLLAGMPVAA-LQVHAGKATFHrfdrfNHRFSPMGMTSLRSLFLKTENFM 1242 Leishmania major
Feature 1                                                                                      
NP_494973  415 GGKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNEWDnlAKWALTHDVWSPNARWLVQIPRLYDVYRAkNMVKNFDDM 494  Caenorhabditis e...
EAA19931   259 EGKYLAEITKQEINILEKSKYQHVEWRISIYGKDKNEWTklAKWVLNNNLTSVRVRWIIQIPRLYHIYKKrKLIYSFQNF 338  Plasmodium yoeli...
P50998     430 NGRYLAELTKEVFTDLRTQKYQMAEYRISIYGRNREEWDklAAWIIDNELFSPNVRWLIQVPRLYDVYKKsGIVETFEEV 509  fission yeast
EAA36130   540 NGRYLAEITKEVIADLESSKYQMVEWRVSIYGKSLDEWDklASWVVDNKLFSHNVRWLVQIPRLYDVYKAsGGVNTFEEI 619  Neurospora crassa
P15274     458 KGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDklASWVIDNKVISHNVRWLVQIPRLYDIYKKtGIVQSFQDI 537  baker's yeast
NP_910462  463 QGRFLAELTKEVFSDLEASKYQMAEYRISIYGRKKSEWDqmASWIVNNELYSENVVWLIQIPRIYNVYREmGTINSFQNL 542  Japanese rice
AAF65407   270 KGKYLAEISKEVFTDLESSKYQCAEYRLSIYGRKMSEWDtlASWIVDNDLFSTKVRWLIQVPRLYDVYRE-TSTTTFQDF 348  Dictyostelium di...
NP_572931  352 NGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYklAKWAIDNDVYSSNIRWLIQIPRLFDIFKSnKMMKSFQEI 431  fruit fly
P23109     399 NGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSklSSWFVCNRIHCPNMTWMIQVPRIYDVFRSkNFLPHFGKM 478  human
AAH44154   425 NGEYFARLIKEVAHDLEESKYQHAEPRLSIYGRAPEEWEslSKWFIMQKLHSPNMRWMIQVPRIYDIFRSkKIIANFAKM 504  zebrafish
CAC14614  1243 QGRYFAELIRIAFKQNELEGGTFTENRLSIYGRHKDEWDrlSRWLVFHGLSHRTNSWMIQVPRLFHLYQRsGQLRSFQEM 1322 Leishmania major
Feature 1                                                                                      
NP_494973  495 LDNLFTPLFEVTNDPSSHPELHLFLQQISGIDSVDDESk-hEFVNFDRSTPCPpeYTDLENPPYNYYLFYMYRNICALNA 573  Caenorhabditis e...
EAA19931   339 LSNIFEPCFEAIKNPEQNKEIFLFLQQIVGWDSVDDESiisKYTLKGGVLPSPdkYISDTNPPYSYYAYYMYANIRALND 418  Plasmodium yoeli...
P50998     510 VRNVFEPLFEVTKDPRTHPKLHVFLQRVIGFDSVDDESk--PERRTFRKFPYPkhWDINLNPPYSYWLYYMYANMTSLNS 587  fission yeast
EAA36130   620 VRNIFEPLFEVTKDPSSHPKLHIFLQRVIGLDSVDDESk--VERRLFRKFPVPkiWDGKQNPPYSYWIYYLYANMASLNH 697  Neurospora crassa
P15274     538 CKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESk--VDRRFHRKYPKPslWEAPQNPPYSYYLYYLYSNVASLNQ 615  baker's yeast
NP_910462  543 LDNIFLPLFEVTVDPASHPQLHVFLQQVVGLDLVDDESk--PERRPTKHMPTPeqWTNVFNPAYAYYVYYCYANLYTLNK 620  Japanese rice
AAF65407   349 LNNVFHPLFEVTKDPSSHPKLHLFLQQVVGIDCVDDESk--FEKKFTEKFPVPgeWSSEHNPPYTYYLYYLYANLYTLNQ 426  Dictyostelium di...
NP_572931  432 LNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESk-pENPLFDNDVPRPeeWTYEENPPYAYYIYYMYANMTVLNK 510  fruit fly
P23109     479 LENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESk-hSGHMFSSKSPKPqeWTLEKNPSYTYYAYYMYANIMVLNS 557  human
AAH44154   505 LENIFLPLFQATVNPQKHKEMHVFLKHVTGFNSVDDESk-hSDHIFNYKSPKPeeWTSEENPPYTYYLFHMYANIMVLNN 583  zebrafish
CAC14614  1323 LTNIFEPLWHASLHPDKYPYLHFFLSHVSGFDSVDNESd--REPDQTIDIPPAq-WTSAENPPFAYYMFYMWINITTLNL 1399 Leishmania major
Feature 1                    #  #                  #                                           
NP_494973  574 FRRARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPvLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEY 653  Caenorhabditis e...
EAA19931   419 FMIARKLRPLTFRPHCGEVGNISHLASMFLLANRINHGIALRKSPvLLYLYYLKQIGLAMSPLSNNALFLSIEKNPFKQF 498  Plasmodium yoeli...
P50998     588 WRKIRGFNTFVLRPHCGEAGDTDHLASAFLLSHGINHGILLRKVPfLQYLWYLDQIPIAMSPLSNNALFLAYDKNPFLTY 667  fission yeast
EAA36130   698 WRKRRGFNTFVLRPHCGEAGDSEHLAVAALCCHSISHGLLLRKVPvLQYVFYLEKIGIAMSPLSNNALFLAYERNPMHQY 777  Neurospora crassa
P15274     616 WRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPfVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRY 695  baker's yeast
NP_910462  621 LRESKGMTTIKLRPHCGEAGDIDHLAAAFLTSHNIAHGVNLKKSPvLQYLYYLAQIGLAMSPLSNNSLFIDYHRNPFPTF 700  Japanese rice
AAF65407   427 FREEKGLNILTLRPHSGEAGEVDHMGAAFYLAHGINHGINLRKTPvLQYLYYLTQIGIAMSPLSNNSLFLTYNRNPFPAF 506  Dictyostelium di...
NP_572931  511 FRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPvLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEY 590  fruit fly
P23109     558 LRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPvLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDF 637  human
AAH44154   584 LRKERGLNTFLFRPHCGEAGSITHLVSAFLTADNISHGLNLKKSPvLQYLYYLAQVPIAMSPLSNNSLFLEYSKNPLREF 663  zebrafish
CAC14614  1400 YRAARGFNTFQFRPHAGESGDPDHMADVFLLADGIGHGINLDKRPvMQYLYYLTQIPLAITPMSNNTLFCRYKDHPLPNF 1479 Leishmania major
Feature 1                 ##                                                                   
NP_494973  654 LQKGLNVSLSTDDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYkeegvl-gndih 732  Caenorhabditis e...
EAA19931   499 FKIGLNVSLSTDDPLMFHFTTEPLLEEYSVCAHVWRLTTMDLCEIARNSIIQSGYEPSFKRHWLGKGGeknspnftsipe 578  Plasmodium yoeli...
P50998     668 FKRGLNVSLSTDDPLQFAFTREPLIEEYAVAAQIYKLSAVDMCELARNSVLQSGFERQLKERWLGVDFqd--------id 739  fission yeast
EAA36130   778 FKRGLNVSLSTDDPLQFAFTKEPLIEEYAVAAQIYKLSPVDMCELAKNSVKQSGYERSIKEQWLGKNFdlpgaq-gntmv 856  Neurospora crassa
P15274     696 FKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFdksgve-gndvv 774  baker's yeast
NP_910462  701 FLRGLNVSLSTDDPLQIHLTKEPLVEEYSIAASLWKLSSCDLCEIARNSVYQSGFSHRLKSHWIGRNYykrghd-gndih 779  Japanese rice
AAF65407   507 FARGLNVSISTDDPLQFHYTKEPLMEEYSIATQVWRLSVCDICEIARNSVLQSGFEHNVKSHWLGPDYansgg---ndik 583  Dictyostelium di...
NP_572931  591 LARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYyedgim-gndit 669  fruit fly
P23109     638 LQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYleegpa-gndir 716  human
AAH44154   664 LQKGLCVSLSTDDPLQFHYTKEALMEEYAIAAQLWKLSTCDTCEIARNSVLQSGLSHQEKKYFLGEKYlddgpe-gndir 742  zebrafish
CAC14614  1480 LYRGLHVAIGTDCPLIFHRTEQPLLEEYGTAEALWNLSAADICELAANSVRASGFPASRKREWLGPLYhlrsva-gndva 1558 Leishmania major
Feature 1                          
NP_494973  733 RTNVPDIRVSFRheALVDEL 752  Caenorhabditis elegans
EAA19931   579 KTNIPKTRMSYRkkTWNEEN 598  Plasmodium yoelii yoelii
P50998     740 RTNVPIIRLAYRalTLTQEI 759  fission yeast
EAA36130   857 KTNVPDRREEFRyrTLLEER 876  Neurospora crassa
P15274     775 RTNVPDIRINYRydTLSTEL 794  baker's yeast
NP_910462  780 QTNVPHIRIEFRhtIWKEEM 799  Japanese rice
AAF65407   584 KTNISDIRVCFRneTLIEEL 603  Dictyostelium discoideum
NP_572931  670 RTNVPEIRVAYRyeTLLDEL 689  fruit fly
P23109     717 RTNVAQIRMAYRyeTWCYEL 736  human
AAH44154   743 KTNVAQIRMAYRheTLCNEL 762  zebrafish
CAC14614  1559 RSHVPQTRCAFRyeAYMEEV 1578 Leishmania major

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