1IRU


Conserved Protein Domain Family
proteasome_alpha_type_7

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cd03755: proteasome_alpha_type_7 
Click on image for an interactive view with Cn3D
proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated alpha-beta-beta-alpha cylinder with a central cavity. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily. Their N-terminal threonine residues are exposed as a nucleophile in peptide bond hydrolysis. Mammals have 7 alpha and 7 beta proteasome subunits while archaea have one of each.
Statistics
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PSSM-Id: 239724
Aligned: 20 rows
Threshold Bit Score: 339.339
Created: 12-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Molecular Biology Databases
 
active sitealpha subunit
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

cd03755 is part of a hierarchy of related CD models.
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cd03755 is a member of the superfamily cl00467
Sub-family Hierarchy
cd01901Ntn_hydrolasecd01906proteasome_protease_HslVcd01911proteasome_alphacd03749proteasome_alpha_type_1cd03750proteasome_alpha_type_2cd03751proteasome_alpha_type_3cd03752proteasome_alpha_type_4cd03753proteasome_alpha_type_5cd03754proteasome_alpha_type_6cd03755proteasome_alpha_type_7cd03756proteasome_alpha_archealcd01912proteasome_betacd03757proteasome_beta_type_1cd03758proteasome_beta_type_2cd03759proteasome_beta_type_3cd03760proteasome_beta_type_4cd03761proteasome_beta_type_5cd03762proteasome_beta_type_6cd03763proteasome_beta_type_7cd03764proteasome_beta_archealcd03765proteasome_beta_bacterialcd01913protease_HslVcd01935Ntn_CGH_likecd00542Ntn_PVAcd01902Ntn_CGHcd01903Ntn_AC_NAAAcd03747Ntn_PGA_likecd01936Ntn_CAcd03748Ntn_PGA
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #               # #             #                    
1IRU_R      3 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQder-tvRKICALDDNVCMAFAGLTADAR 81  cattle
P34120      6 YDRAITVFSPDGHLFQVEYAMEAVRKGTVAVGVRGKDVIVLGVEKKATAKLQdar-siRKIVKLDDHICLTFAGLTADSR 84  Dictyostelium disc...
Q10329      4 YDRALSVFSPDGRLLQVEYGQEAVRRGTTAIALRGNECIVIGVERKNVPKLQnvs-nfQKIAMVDNHVCLAFAGLNADAR 82  fission yeast
Q9NDA2      3 YDRAITVFSPDGHLFQVEYAQEAVRKGLCAVGVKGKDSIIFAVEKKSVQKLQdsr-ttRKIYKLDEHIYLASAGLSADAR 81  Trypanosoma brucei...
P22769      5 YDRAVTIFSPDGHLLQVEYAQEAVRKGSTAVGVRGANCVVLGVEKKSVAQLQedr-kvRKICMLDNHVVMAFAGLTADAR 83  fruit fly
NP_705423   3 YDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQnpk-ttEKLIKLDEHNCLAFAGLNADAR 81  Plasmodium falcipa...
XP_326295   5 YDRALSVFSPDGHVFQVEYAGEAVKRGTCAVGVKGKDVVVLGCEKRSAMKLQdtritpSKIGLVDKHVCLAFAGLNADAR 84  Neurospora crassa
AAS21469    4 YDRAITIFSPDGHLFQVEYAQEAVEKGATAVAVRGDNVVVLGVEKKATQKLQedr-tvRKICSIDNHIALAFAGLTADAR 82  Oikopleura dioica
AAW42969    5 YDRALTVFSPDGHLFQVEYALEAVRRGTCAVGVRGKSCVVLGVEKKSTLQLQdpr-tvRKVAMLDDHVCVAFAGLTADGR 83  Cryptococcus neofo...
XP_626367  16 YDRAITVFSPDGHLLQVEYAMEAVRKGYGAIGVRGAECVVLAVERKAVAKLQdpr-saKKLLLVDDNTCLAFAGLHADAR 94  Cryptosporidium pa...
Feature 1                                                                                     
1IRU_R     82 IVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDfd-gtPRLYQTDPSGTYHAWKANA 160 cattle
P34120     85 VLISKALMECQSYRLTVEDSPSVEYISKFIAGIQQRYTQSGGVRPFGISTLIVGFDtd-gtPNLYQTDPSGSYSSWKAAA 163 Dictyostelium disc...
Q10329     83 ILIDKARVEAQNHKLNLADPVSIEYLTRYVAGVQQKYTQSGGVRPFGVSTLIAGFDvgdntPRVYQTEPAGIYNAWKATA 162 fission yeast
Q9NDA2     82 VVVNHAQLECQRFRLSYEDAIDVDLLVRYVARVQQRSTQSSGSRPYGVSTIIGGFNen-gqPQLWKTEPSGTSSAWNAAA 160 Trypanosoma brucei...
P22769     84 IMINRAQVECQSHRLNVEDPVTLEYITRFIAQLKQKYTQSNGRRPFGISCLIGGFDad-gsAHLFQTEPSGIFYEYKANA 162 fruit fly
NP_705423  82 VLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKnn-keICIYQTEPSGIYAAWKAQA 160 Plasmodium falcipa...
XP_326295  85 ILVDKARLEAQSHRLNLEDPVTIEYITKYVAGVQQRYTQSGGVRPFGISTLIVGFDngsdvPRLYQTEPSGIYSAWKANA 164 Neurospora crassa
AAS21469   83 VMIDRARTECQQHRLTVEDAVTVEYITRSLANLKQKYTQSNGRRPFGLSSLIVGFDphtnaAKLFTTDPSGTYSEWKANA 162 Oikopleura dioica
AAW42969   84 ILIDKARIECQSHRLTVEDPVSIEYITKHIAGIQQRYTQSGGVRPFGISALIVGFDphdtiPRLYSTEPSGIYSAWKACS 163 Cryptococcus neofo...
XP_626367  95 VLVNKIRLECQNFRLNIEDAPPVDYIARFTAQQQQKYTHRGGVRPFGVSTLIAGVHnd-gsPGLYQTDPSGIALEWKAQA 173 Cryptosporidium pa...
Feature 1       #                                                
1IRU_R    161 IGRGAKSVREFLEKNYtdeaietddlTIKLVIKALLEVVqsggkNIELAVM 211 cattle
P34120    164 IGRSSKSVGEFLEKNYtdvs---eeeSIKLAVRALLEIVesgnkNIEIAVI 211 Dictyostelium discoideum
Q10329    163 IGRASKAAREYLEKNWkegl--srdeTIHLAVSSLLEVVqtasgNIELAIM 211 fission yeast
Q9NDA2    161 IGRNDKVVLEFMEKNYqdgm--trdrCVHFAIKALLEAVesgskNIELLVL 209 Trypanosoma brucei brucei
P22769    163 TGRSAKVVREFFEKSYreeevanehgAVKLAIRALLEVAqsgqnNLEVAIM 213 fruit fly
NP_705423 161 IGKNAKIVQEFLEKNYqenm--eqkdCIFLALKAIFEVVelsskNVEVALL 209 Plasmodium falciparum 3D7
XP_326295 165 IGRSSKTVREFLERNYkddm--dreaTIRLTIKSLLEVVqtgakNIEIAIM 213 Neurospora crassa
AAS21469  163 IGRSSKTVREFLEKNYneegv-pendALKLVCQALLEVVqssskNIELAIM 212 Oikopleura dioica
AAW42969  164 IGRASKTVREFLEKNYvedl--ereqAIKLTVKSLLEVVqtgakNIEITVM 212 Cryptococcus neoformans var. neoformans JEC21
XP_626367 174 VGQNSKTVQEFLEKNYkhdm--akeeTINLAISALLEVVesgsrNMEIVVV 222 Cryptosporidium parvum Iowa II

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