Conserved Protein Domain Family
MFS_GLUT6_8_Class3_like

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cd17358: MFS_GLUT6_8_Class3_like 
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily
This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340916
Aligned: 40 rows
Threshold Bit Score: 366.515
Created: 16-Mar-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
chemical
Feature 1:chemical substrate binding pocket [chemical binding site]
Evidence:

cd17358 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd17358 is a member of the superfamily cl28910
cd17358 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #   #                                                              
Q9UGQ3        39 FLATFAAVLGNFSFGYALVYTSPVIPALersld--pdlhLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSA 116 human
NP_995620     11 YLAAISVNIISISYGAFCGWPSSSFLELssenspldtgpLTPTDQGWVASNICLGGLVGTFLFTWLADRIGRKLCLMWMA 90  fruit fly
NP_608766     26 FLVTLLLNIATFSHGLGVGWMSPVMRDLqtdes-pldfpVLVSQVSWIGSLVGIGSVMGNLIAGLLMDRIGRKMVLFFIA 104 fruit fly
NP_608761     19 LLVSLSATLITFCHGIALGWLSPMLPKLlspqetplsfyIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALA 98  fruit fly
NP_608767     21 LLTTLLINVISISHGIGIGWLSPTLRKLqsdsp-agfevKSEFEISWVGSMLGMGSVTGNILIGCLLGRLGSKRCLLLIA 99  fruit fly
NP_726368     59 ILATCAVLLLSAGCGMPIGFSAILLPQLmdnns--teipIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSV 136 fruit fly
NP_001097067  18 LLATVIVNIITFGHGVGVGWLSPTLTKIqtads-pldfeVNLAQISWLGSMLGLDSLCGNLTIAMLIERAGRKFCLYLMA 96  fruit fly
NP_608764     14 SVATALGNILCFNFGLMFGITPAHMTLYeseertplnqaTDPAGTAWLTGYLFLSAALGALVSGFLALKIGPKSVLLCSG 93  fruit fly
NP_001334690  20 FIATMTVHIMTLTHGIAVGWLSPSLRLLasdes-plgdpLTITQASWVGSLIGLGSLTGNIIFGLLLDRLGRKVCMYFLA 98  fruit fly
NP_611060     46 VIAVILANVGVFSTGMTLAMPTATLHQLkdtt---epvhLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLN 122 fruit fly
Feature 1                                                                        #  ##  #        
Q9UGQ3       117 VPSAAGYALMAGAhg------lwMLLLGRTLTGFAGGLTAACIPVYVSEiap-pgvRGALGATPQLMAVFGSLSLYALGL 189 human
NP_995620     91 LPNLLGWVIIPFArt------pmHLIIARFIGGAAGGGCFTVIPIYIAElas-dniRGILGVFLVLTCNFGLVLAFVLGY 163 fruit fly
NP_608766    105 IPYTTFWCLIYFVqs------veFLYIGRLMAGITGGACYVVLPTFISEiad-tnvRGRLGSIILLSVNTGVLAGYIVST 177 fruit fly
NP_608761     99 VPHTCIWFLFYFAqs------ieWLYVARVFAGLTGGGMFVVLPIFIGEiad-nsiRGRLCSFFTLTMNTGIMVGFVVSS 171 fruit fly
NP_608767    100 IPHSCFWILVYFAqs------veYLYVGRLLAGICGGGMYIVHPILLSEiad-aniRGTFSAMVMLSVNVGILVGYIIGT 172 fruit fly
NP_726368    137 IPLLLGWSTLAIAks------ikVVIFARFLCGFATGILGGPGQVYIAEtae-pnlRSLLIGAPYVAYSSGILMVYSLGS 209 fruit fly
NP_001097067  97 GPYACIWILIYCAsn------vyYLYAARFLCGFTGGAGYLVVPIFISEvad-sniRGALTSMVMLSVDLGILAGYILST 169 fruit fly
NP_608764     94 LLQISGWACIHFGyd------ivHIYASRLFAGVASGAAFVVLPIFINEiaesrekAARLTFTIELWRTLGILIGFVLGF 167 fruit fly
NP_001334690  99 IPNMIYWILIYSAqd------vtYLYAGRFLAGMSGGGCYVVLPIFIAEiad-nsvRGALSSMAMMYVSIGMMVGFTLAS 171 fruit fly
NP_611060    123 VLIILAWILLATPsesdqnaffwQLIVSRFMLGVGMGLASAPPGVYAAEisv-pktRGSLILGTSISVAGGITILYGIGY 201 fruit fly
Feature 1                                                                                        
Q9UGQ3       190 LLp--WRWLAVAGEAPVLIMILLLSFMPNSPRFLlsrGRDEEALRALAWLRGTDVDVHWEfeqiqdnvrrqss------- 260 human
NP_995620    164 YFn--YAQVSWIVSSLSFVFVGCFWFMPETPQHLakiNKIEEAEHSLRYYRNIKSNPAKElseelqlelqklkttektta 241 fruit fly
NP_608766    178 RVd--YFTSPPFIIGLPVCYFICNFLIPETPHHLvrkGKFEAAKRSFMFYKNIRKNDIKAedefeemkyllikeqte--- 252 fruit fly
NP_608761    172 HIa--YHVIPCAVVGLPVLYVLLATRYPEPPQQLirwKREEEAEKSLRYYRRCDGPNVSKeeerayqkhfdemrlaiqqq 249 fruit fly
NP_608767    173 HLp-yYSIPLMVLILPLWYLISVLLFIKESPMHLiriGKYSAAERSFRYYKNIKDSDNIHdqnrameefeimkialtkg- 250 fruit fly
NP_726368    210 MMy--WRSVAWCANVLPLLSMVSISFIPETPAWLlrnGHEKRALQALSFLRGSEISAQKElndmkqrlakervttk---- 283 fruit fly
NP_001097067 170 YLa--YHVVPFLAIILPVAYFIANIMLPETAPYLlkkSQLAAAENSFRYYRNQRSAICEQtskvnfeelrtavlsqqt-- 245 fruit fly
NP_608764    168 YVp--YAFVNIVGCAVSFVFTMTFPFVQESPHYYlrkNNMASLEKSLRWYRGIRDIDDREkpeylselnefhaelrs--- 242 fruit fly
NP_001334690 172 YLp--YYLMPCIIVALPVVFMLSVIGLSETPQYLlrrGRDDQAEKSFYFYKNLTPPTSSDkeasqhdaakiefdtfrlqv 249 fruit fly
NP_611060    202 CIrddFRLIALICCGYQLVALLCVLPLPESHCWLlskKRVTEAKRSLNYFRGFNKSDEIThpqvleefqllqkslqqr-- 279 fruit fly
Feature 1                                           ##   ##  ##                         #        
Q9UGQ3       261 ----------rvswaearaphvcRPITVALLMRLLQQLTGITPILVYLQSIFdstavllpPKDDAAIVGAVRLLSVLIAA 330 human
NP_995620    242 dgvddddaatgvtwsdfaegktrKAFLIGLGLISFNQLCGCFAMLNYTAVIFeqagsslpPTVAAIIVGVIQLMGTYAST 321 fruit fly
NP_608766    253 -------kaksfdyrdfitrpafKAYASAAVLLISNQFSASFCVTTYLADVFaashttlnLGMCTIIIGVLQIVGNYVTT 325 fruit fly
NP_608761    250 ---nndtddnglsmsdfltkrslKALATGLVLMVANIFTGTFAFNNYMSNIFdavhtqldPNTNTIIIGAVQILGTLASI 326 fruit fly
NP_608767    251 -----dalqdavtfkdfysrpalKAYGPALVLLIANQFSGLFTMVNYMSDIFansgstmdPDTCTIIIGAVQILGTYVTT 325 fruit fly
NP_726368    284 --------tnenifqlccqrvaiKPLVIVIVFSLLQMFSGTFIVIFYAVDMIsefgaefdSKQAAIATAVVRVICCMVFC 355 fruit fly
NP_001097067 246 ------rnatplsykdlttkpalKGFAASIVLSLGYQFSGVFSFINYMSDIFkasgsvvdVNTATIIIGLVQIVGVYTST 319 fruit fly
NP_608764    243 -------rdknvgstpmshgyiiRLTFVSFLLTVCAKLSGVFVELNYAADFLgrt--gysTETNYVVLASAQCAGALLAR 313 fruit fly
NP_001334690 250 ---lsggvtesiswrdfinvptlKIFGLIFVLIICNQLSGSFAIFNYTSHIFaelgnnldPNTSTIVVGAAQLVGIFSAV 326 fruit fly
NP_611060    280 -----ntavkesfwrnlhepevyKPLVILMSLFAFQQLTGIFVVIVFAVQISqeagieidPFMCAVLIGLARLITTCPMG 354 fruit fly
Feature 1                                                                                      ##
Q9UGQ3       331 LTMDLaGRKVLLFVSAAIMFAANLTLGlyihfgprplspnstagleseswgdlaqplaapagyltLVPLLATMLFIMGYA 410 human
NP_995620    322 VLVERlGRKILLLVSAVGIGLGQSAMGtysyfqml----------------------gcpvasfsWVPIAGFSFMLFLAA 379 fruit fly
NP_608766    326 LLCDKyGRRILMLTSTLGASVCLTAFGtftffaea-----------------------adlssvdWLPLVILSCFVFLCN 382 fruit fly
NP_608761    327 YLVDRyGRKILLIVSCAGSGIGTSAFGlyafyaeeq--------------------kvdlsafsaWLPVTLMAFIIFIAN 386 fruit fly
NP_608767    326 LLCDIcGRKLLMLVSTGGVAISLTAFGfftkyaes-----------------------hnigeysWIPLLLMSMDIFLGN 382 fruit fly
NP_726368    356 VVLIFvRRRRIMIVSGIGSGLFCLVLSvyqyarfd-----------------------qpkmsydVFVGAGCLLGYIIFN 412 fruit fly
NP_001097067 320 ILVDIvGRRVLMLISTMGVGIGCIAFGcftylaki-----------------------ydlsdfnWLPLVLMIIICYVAN 376 fruit fly
NP_608764    314 LVGPRlPRKLLLCLSSLFAAAAVIALAlfkayghlw---------------------llgnwadrYLPIILLAIQLALVS 372 fruit fly
NP_001334690 327 VLVDRlGRRVLLLTSMGGMGLGELAIAllkcfasd-----------------------eflnqngWLPLVIMCLVACIAS 383 fruit fly
NP_611060    355 YILEWwGRRRAGIISTLGMSVCMFLLAghsqie--------------------------ilkevpYLPVVAIVGFIVLST 408 fruit fly
Feature 1          ##   #                      ##  #                                             
Q9UGQ3       411 VGWGPITWLLMSEVLPlRARGVASGLCVLASWLTAFVLTKSFlpv--vstFGLQVPFFFFAAICLVSLVFTGCCVPETKG 488 human
NP_995620    380 VGLLSLPFLVVSEIMPqKIRSTAIMILMSTLWLISTCAVKLMpvf--tesLGMHGTVFMFASLSFLAAIFIAIFVPETKG 457 fruit fly
NP_608766    383 IGLVGCLFVVLVELFPaKIRSVSVSTFVVILSSTVFLTLKIFpic--mavWGTSVTMWSCSGITFFSFLYFCFFLEETNG 460 fruit fly
NP_608761    387 VGVISVTMVVLVEILPqKIRAVATSFCLGCLSFFAFASLKTFplm--mfhLGLAATMWFCAAVSVICLFYVVVCLEETKG 464 fruit fly
NP_608767    383 IGLVGCFFVSLVEMFPvKIRAKAASMAIVVCSIFVFLMLNIFpic--mkqWGISATMWSCAGVTALSSLYFTYFMKETKG 460 fruit fly
NP_726368    413 TALMVMPGIMIGELFPaRIRGRTAGGVFASMNVALFIFAKKFpal--qamLKMRGVFLVFGVSSFLLTAFMCLFQPETKG 490 fruit fly
NP_001097067 377 IGLIGIFFLVLVELFPvKIRSLATSLSVIFLSLLVFGTLKLFplm--lhyWGISFTMWFSAASALLTFFYFWLFLQETKG 454 fruit fly
NP_608764    373 FGLYPLAAVVSSEVLPtKLHDLLYSLASAVSWLLLFGMIEAFnavkatiaPGLLLYLWVFAGASIFVGLISLPLLPETRN 452 fruit fly
NP_001334690 384 LGVIALIFIIIIELLPaKIRSIGTSLSMATFSGFIFVALKIYptm--iydQGLAATMFMSAGMCLFGFIVLGLFLPETKG 461 fruit fly
NP_611060    409 LGLYTLPFFMISELFPqKVRGPASGLTVAVGMFISFVVLKTYpgi--keyLGMSNCFIIFGVMALFALIFVYLALPETRR 486 fruit fly
Feature 1             
Q9UGQ3       489 RSLEQ 493 human
NP_995620    458 KSVDA 462 fruit fly
NP_608766    461 KSLLA 465 fruit fly
NP_608761    465 RSMYD 469 fruit fly
NP_608767    461 KSMLD 465 fruit fly
NP_726368    491 RSLEH 495 fruit fly
NP_001097067 455 KSMIE 459 fruit fly
NP_608764    453 RRPSA 457 fruit fly
NP_001334690 462 KLMTH 466 fruit fly
NP_611060    487 RTLLE 491 fruit fly

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