Conserved Protein Domain Family
7tmA_Octopamine_R

?
cd15063: 7tmA_Octopamine_R 
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors
G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.
Statistics
?
PSSM-Id: 320191
Aligned: 5 rows
Threshold Bit Score: 280.151
Created: 13-Nov-2008
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                 #   
NP_732541  21 LISLAVLEFINVLVIGGNCLVIAAVFCSNKlrsvTNFFIVNLAVADLLVGLAVLPFSATWEVfk-vWIFGdlwCRIWLAV 99  fruit fly
O77408     29 VLSSVLLCAVVLLVLVGNTLVVAAVATSRKlrtvTNVFIVNLACADLLLGVLVLPFSAVNEIkd-vWIFGhvwCQVWLAV 107 great pond snail
Q93126     34 LISLLALAFLNLMVVAGNLLVVMAVFVHSKlrtvTNLFIVSLACADLLVGMLVLPFSATLEVld-vWLYGdvwCSVWLAV 112 Balanus amphitrite
NP_491954  59 FSIISVLTVLVVVVVLGNALVIAAVLLRRRlrsaTGLLILSLALADLLVGTVILPFSIANEVldqyWIFGetwCTIWLTL 138 nematode
EEC06898   41 LVTFLILGLINVLVIFGNLLVMVAVLCSTKlrtvTNYFVVSLAVADLSVGIIVLPYSIVLEVle-vWIFGhtwCQIWLAV 119 black-legged tick
Feature 1     ##  ##                                                                          
NP_732541 100 DVWMCTASILNLCAISLDRYVAVTRPvtypsimSTKKAKSLIAGIWVLSFFICFPPLVGWkdqkaviqptypkgnhtlyy 179 fruit fly
O77408    108 DVWLCTASILNLCCISLDRYLAITRPirypglmSAKRAKTLVAGVWLFSFVICCPPLIGWndggdgimdyngttatpipv 187 great pond snail
Q93126    113 DVWMCTSSILNLCAISLDRYLAVSQPisypslmSTRRAKQLIAAVWVLSFVICFPPLVGWndrpgtlig----------- 181 Balanus amphitrite
NP_491954 139 DIWMCTASIYNLVAISIDRYIAIIKPlnypmlvTKFRARCTVAIVWIGSFLICSPSFFLAssikd--------------- 203 nematode
EEC06898  120 DVWLCTSSILNLCAISVDRYLAITRPvryrslmSSKRAKLLIVAVWVIAFVICFPPLVGWndgte--------------- 184 black-legged tick
Feature 1                                                                                     
NP_732541 180 tttmsssedgqlgldsikdqgeaslppspphigngnaynpydpgfapidgsaeiriaaidstststtatttttasssstt 259 fruit fly
O77408    188 tttqtpvtgrd-----------------------------------------------------------------dvlc 202 great pond snail
Q93126        --------------------------------------------------------------------------------     Balanus amphitrite
NP_491954     --------------------------------------------------------------------------------     nematode
EEC06898      --------------------------------------------------------------------------------     black-legged tick
Feature 1                                  #       #  ##  #                                   
NP_732541 260 etemdldllnappqnrpqtisgscpwKCELt-nDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAvrttrainqgfkttkg 338 fruit fly
O77408    203 dngfnystnsnmnttctysgdsslstTCELt-nSRGYRIYAALGSFFIPMLVMVFFYLQIYRAAvktisayakgelktky 281 great pond snail
Q93126    182 -----------------srgssacrlTCELt-nERGYVIYSALGSFFLPSTVMLFFYGRIYRTAvsttraiaqgfrttke 243 Balanus amphitrite
NP_491954 204 ---------------------ketpcRCTPanaGRVYVVFSASSSFYIPMIIVVFVYFRIYVAAraatksiysgmmsvta 262 nematode
EEC06898  185 ----------------------nlsaQCVLi-nNKGYVIYSALGSFYIPMLFMLFFNYRIYRAAiqtgralergfittks 241 black-legged tick
Feature 1                                                                                     
NP_732541 339 skgigsrfeeqrltlrihrgrgsnqqdsmhsngstqsttttlgtpsperlskyatrrlhhhdkikisvsypssenisel- 417 fruit fly
O77408    282 svrengsktnsvtlrihrggrgpstgssvyrhgstyggsaagaatregcgdkdaaggrrfgrqemdshlpvrkcrssdas 361 great pond snail
Q93126    244 deegrltlrihrgrsvtqraeqaaaggarahgqvrltlsepgarrqnkpsfvvh-------------------------- 297 Balanus amphitrite
NP_491954 263 aankkqnpksyllnhpdvinkdslpmlrvhrgssvvaqitpnkpyntcrqngnsidatangtsqitaaatkarkfandsa 342 nematode
EEC06898  242 gkikgrtqeqrltlrvhrgndsglnvkrgsehvgaetcidgivtgrrrpglkks-------------------------- 295 black-legged tick
Feature 1                                                                                     
NP_732541 418 --------------------------------------------------------aghgdvgherrqsgnalfavhyng 441 fruit fly
O77408    362 lvtltglkceiidngnakhgpiselikgrgksffwrkekkrsvggeresfenstrngrstraklcggrclaietdicssg 441 great pond snail
Q93126        --------------------------------------------------------------------------------     Balanus amphitrite
NP_491954 343 ktlvnrgavgatqqapigar--------------fkrhgrdsessvdsmngtnsysatphksgneelgsliensrssstd 408 nematode
EEC06898      --------------------------------------------------------------------------------     black-legged tick
Feature 1                                                                                     
NP_732541 442 tngrestesqlyrqqqqhgvasscylqvgkglpelarrqsntseaggsghsrpankkmgrrnikaqvkrfRMETKAAKTL 521 fruit fly
O77408    442 ecsprtkrikeharatqhnslpvtpslssqneetdavfvrgtsnseykprrsrlsahkpghamrlhmqkfNREKKAAKTL 521 great pond snail
Q93126    298 -credsraknqyeiytvvegdsrpgrrvpqpqrpakklssasqsseddsrpprfisrvsrrnvrhqarrfRMETKAAKTV 376 Balanus amphitrite
NP_491954 409 snekteqltnqtddnfsmsnnnnngdekeafdesllseskkkskslaskfnhlmrrgqkkrtagayekrlSLEIKAAKTV 488 nematode
EEC06898  296 -rdepsasarssgkksrasqadveratrsappsfkskrgsvrnsgrngtsggskssrsskrsqrwqakrfRTEAKATKTV 374 black-legged tick
Feature 1               #  ##  #              #   #   #                     
NP_732541 522 AIIVGMFIFCWCPFFTMYIIRpfcqdcvDPLLFSVLFWLGYCNSAVNPMIYALFSkdFRFAF 583 fruit fly
O77408    522 AIIVGAFIMCWMPFFTIYLVGafcenciSPIVFSVAFWLGYCNSAMNPCVYALFSrdFRFAF 583 great pond snail
Q93126    377 GIIVGLFILCWLPFFVCYLVRgfcadcvPPLLFSVFFWLGYCNSAVNPCVYALCSrdFRFAF 438 Balanus amphitrite
NP_491954 489 AIVTGCFIFCWLGFALVYGLEik----lNDVVWSIVFWLGYLNSALNPVIYTVFNreFRICF 546 nematode
EEC06898  375 GTIVGGFICCWLPFFTVYLVRafcehciPNLLFSVFFWLGYCNSALNPLIYALVSkdFRLAF 436 black-legged tick

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap