Conserved Protein Domain Family
RING-H2_RNF44
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cd16680: RING-H2_RNF44 
RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins
RNF44 is an uncharacterized RING finger protein that shows high sequence similarity with RNF38, which is a nuclear E3 ubiquitin protein ligase that plays a role in regulating p53. RNF44 contains a coiled-coil motif, a KIL motif (Lys-X2-Ile/Leu-X2-Ile/Leu, X can be any amino acid), and a C3H2C2-type RING-H2 finger.
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Statistics
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PSSM-Id: 438342
Aligned: 3 rows
Threshold Bit Score: 137.891
Created: 24-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #  #              # #  #  #          #  #            
Q7L0R7       371 DSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKaNRTCPICRADASEVPREAE 432 human
Q08CG8       387 ENHQSEQTLCVVCFSDFESRQLLRVLPCNHEFHAKCVDKWLKtNRTCPICRADASEVHRDVE 448 zebrafish
XP_007910507 265 ENHQSEQTLCVVCFSDFESRQLLRVLPCNHEFHTKCVDKWLKtNRTCPICRADASEVHRDLE 326 elephant shark

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