6CES


Conserved Protein Domain Family
IML1

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pfam12257: IML1 
Vacuolar membrane-associated protein Iml1
Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy.
Statistics
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PSSM-Id: 463510
Aligned: 99 rows
Threshold Bit Score: 326.384
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CES_D        101 ELTFKDQYIGRGDMWRLK-KSLVSTCAYITQKVEFAG-IRAQAGELWVKNEKVMCGYIS-EDTRVVFRSTSAMVYIFIQM 177 
CCU74755      198 ELSFKDEYLARSDMWRLTvSELSGNTVYHGQKVLFMGsIKAQVTAIHRDNRKVQSAYFA-IDTKPIFRSCSARYTLFIQM 276 
XP_012743365  187 EMSFKDEYLSRSDMWRLTlAKLSNKTVYKGQKLVFMGtIKAQITSVYVSGRKVQSAFFS-TNTKPIFRSESARYVLFIQM 265 
XP_001590504  116 EMSFKDQYLARSDMWRLTvGEMVDKAVYKGQKILFMGtIKAQVTSVYIGGRKVESAFFS-ATTKPIFRSESARYVLFIQM 194 
EPE35742      204 ELSFKDEYLSRSDMWRLAvGELADKTVFKGQKIIFLGsIKAQVTSIYIAGRKVQSALYS-ANTKPVFRSESARYVLFIQM 282 
XP_007680848   59 ELSFRDTHLSRADMWRIL-HRLERTVVYKGQQIHYLGrAVCEIRAVYISGSEVESALVVqAKTRPIFRSGSARYTILVQI 137 
EME40916      100 ELFFREQFLSRADMWQLM-GRVQETVVYQGQIVNYLGtAVGEIQQVYIAGQEVESAICShPYTKAIFRSGSARYTLLIEV 178 
EGP84331        1 ELMFRDQYLSRADMWQLL-GRVQDTVLYRGQVLNYLGnATAEVKHIYISGNEVESGFCShPQTKAIFRSASARYTILVEI 79  
EME78791       96 ELLFREQYLNSADMWQLM-KRVQHTVVYKGQVMKYLGsITAEVRSVWIAGKELDSAFCShPETKAIFRSASARFTLLIEV 174 
XP_011113948  166 EISFRDQYLSRSDMWRLAaNELAGHCIYSSRRINFVGsIKAQIHGIWIRGQKVQSAYFS-SKTRPIFRSSSARFVLFAQM 244 
6CES_D        178 SCEMWDFDIY--GDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTF------YDAksvdefpein---rasirqdh 246 
CCU74755      277 SREMWDFDYEgsGEIMFNQVINGFLPGLFKRWAALKFEHLVSIVLFARVE------YDTgitqglasethsdsyytgiqp 350 
XP_012743365  266 SKEMWDFDSEgsGEIVFTKVVNGFLPALFKRWVALKAKHLVSIVLFTRVE------YDMgltndmegsg--dsyytgyft 337 
XP_001590504  195 SREMWDFDSEgsGEIMFNKVVNGFLPALFKKWVQLKVKHLVSIVLFTRVE------YDTglaselarsshdtayhtgvqt 268 
EPE35742      283 SREMWDFDSEgsGEIMFNKVVNGFLPALFKKWVALKAKHLVSIVLFTRVE------YDTgiaselaaathdvsyhtgmqa 356 
XP_007680848  138 SLEMLQYWRD--GDLMHERLISGYLTELFRRWNEQKVRHHVTIVLFGREVlpvvdvV----------------------- 192 
EME40916      179 SQEMLENWSN--GDLMYERLLDGFLPELFQRWDKLKVKHQVAVVLFGRTQsv--iaA----------------------- 231 
EGP84331       80 SQEMLSSWSN--GELMYERLLNGFLPDLFNRWKTLKVRHQVSVILFGRSKva--ngN----------------------- 132 
EME78791      175 SREMLEGWSQ--GELMYERLIYGFLWDLFHRWERAKVKHHVSVVLFGRSLva--pgE----------------------- 227 
XP_011113948  245 SKEMWHFENEgkGDILFNKMINGFLPELFKRWKRLNAHHLVSIVLFTRIV------YDGetkigamdtg---denialtt 315 
6CES_D        247 kGRF--------YEDFYKVVVQNERREEWTSLLVTIKKLFIQYP--VLVRLEq------------------------aEG 292 
CCU74755      351 sGSRr------pYKDFYRVVVYEMSSGSWTTILYQLKLEFKFFRkdILTHHLksyipgskkt-------sgkisngasSP 417 
XP_012743365  338 tGSRk------pYKDFYRVVVSEMASGEWTTILYQLKVEFHFFRhdISMFRLnkygskqpt--------rdfsmgsvpGT 403 
XP_001590504  269 dGNKk------pYKDFYRVVVSEMASGEWTTILYQLKREFKFFRkdISMHRIelvtasgap--------fsatnkgtlGT 334 
EPE35742      357 eGNKk------pYKDFYRVVVSEMASGSWTTILYQLKREFKFFRrdISLHRIklvnalsst--------tgdssrgvlGT 422 
XP_007680848  193 -GEQga-----eSRDFFHLIATDAMSSQWSDVRRQLKRAFNGTSl----------------------------------- 231 
EME40916      232 -GKRdsqqsellSKDFYHVMVSDMTSTTWQRILRKLKAAFNDYRl----------------------------------- 275 
EGP84331      133 -GKHdsye-sghGEDFFHVLVSEIVSSNWPLIIRKLKQAFNDRTl----------------------------------- 175 
EME78791      228 -QKRmsas-ekqNDDFFYVLASELPSSSWAEIVKKLKEAFNDLTl----------------------------------- 270 
XP_011113948  316 yGKPv------qYRDFFRVVVTHRESEDWTVILHQLKKEFSVFLrdILVQPTkvppdtpieqpispgtaadpddpfpeSY 389 
6CES_D        293 FPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQ 372 
CCU74755      418 RIEAESSLAMYGNLLEAINLSCSQFSYENIDRDLMRTGVSILFITPCAGLFEVDFQILKMTAEMLSENSISIELVCLPRM 497 
XP_012743365  404 RVEAEPTFAVHGNLLEAINLASSQFSSDYIDRDLIRTGISIVIITPCAGLFEVDYEKLKATTDSLIGSGIAIDLVCLPKI 483 
XP_001590504  335 RIEAEPSLAMHGNVLEAIDLASTQFAHDYIDRDLVRTGISIVVVTPCAGLFEVDYETLRKTTESLIGNGIGIDLVCLPKM 414 
EPE35742      423 RIEAEPSLAIHGNVLEAINLACSQFAHDYIDRDLMRTGISVVVITPSPGLFEVDYKMLSMTTENLIGNGIGIDLVCLPKM 502 
XP_007680848  232 --PRLVSLAASGNMLQALHVSAMDFANDNIDPQLSSTGSSIIAVTAGAGLFETTHTALKNITHLLMGNSIGVDIVSLSPK 309 
EME40916      276 --PRAVSLAAESNLLEAIHLTAMDYADDQIDAHLLSTGCSIIAVTAGAGLFDADHKLLKQTTDLLVGNSIGVDVVALTPK 353 
EGP84331      176 --SRAVSLAAESNMLEAIHLTALDFSDDQTDTHLMSTGTSIIAVTAGTGLFDADHTLLKQTTDLLIGNSIGVDIVALSPR 253 
EME78791      271 --SRAVSLASASNMLEAIHLTAMDYADFYTDAHVMSTGTSIVAVTAGTGLFDANHELLKQTTDLLVGNSIGVDIVALSPK 348 
XP_011113948  390 AICGEPSNSIQGNILEAINLACNQFSRDHVDRDLVRTGISIIIITPGTGYFEVDYEMLQMTTENLVANGIGIDLVCLSRP 469 
6CES_D        373 PLHAVPLFK 381 
CCU74755      498 PLHLTPLFR 506 
XP_012743365  484 PLHSVPLLR 492 
XP_001590504  415 PLHSVPLFR 423 
EPE35742      503 PLHSVPLFR 511 
XP_007680848  310 PLHPVPLFS 318 
EME40916      354 PLHPVPLFQ 362 
EGP84331      254 PLTPVPLFK 262 
EME78791      349 PLHPVPLFK 357 
XP_011113948  470 PLHSTPLFR 478 
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