Conserved Protein Domain Family
DD_CATIP
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cd22973: DD_CATIP 
dimerization/docking (D/D) domain found in ciliogenesis-associated TTC17-interacting protein (CATIP) and similar proteins
CATIP, also called C2orf62, plays a role in primary ciliogenesis by modulating actin polymerization. It interacts with TTC17. Mutations in CATIP may contribute to asthenozoospermia through its involvement in actin polymerization and the actin cytoskeleton. CATIP contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of cAMP-dependent protein kinase (PKA).
Links
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Statistics
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PSSM-Id: 438542
Aligned: 71 rows
Threshold Bit Score: 55.164
Created: 4-May-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative dimerputative AKAP
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the dimer structures of mammalian RIalpha and RIIalpha D/D domains
  • Comment:The Dimerization/Docking (D/D) domain of R subunits dimerizes to form an X-type four-helix bundle .
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  ##  ##  ##  ## #### ##  # #  
Q7Z7H3       316 SYLRQHPEAHALISDFLLFLLLRQPEDVVTFAAEFFGPFD 355 human
XP_025830962 391 QYLKDHQELKNILSDYLSRILIMKPTEVIDFTVDYFKQYA 430 emerald ash borer
KOC68582     213 EYLDDHPEIKQTISDYVQTLLVVKPQNVIDFTIQHFKVFA 252 Habropoda laboriosa
ERL95475     252 TYLKDHPEIQDMLSDYLNSVLLLKPENVMPFTVDYFMNFE 291 mountain pine beetle
XP_019871779 351 TYMSDHPEIKAIIADYMQHVLLLKPSKVVEFSCEYFKKLA 390 small hive beetle
XP_018576523 256 TYMADHPEIKELIADFVQNVLLLKPENILLFTKDYFQNLY 295 Asian longhorned beetle
VEN54252     143 TYMSDHPEVKDILGDYVNNIIMLKPGNVIAFTMNYFQNLF 182 cowpea weevil
XP_014599075 300 EYLTDHVEVKHLIADYTQTLLIVKPLHVVDFTIQYFKAFS 339 Polistes canadensis
XP_024945077  34 DYIDKHPQLKKLVANYVQALTVVKPVNILFFTIQYFKAFA 73  wheat stem sawfly
XP_030384475 365 SYLARHPELNELVQDYVNCLLTYKPTNVLEFSIKYFQSFE 404 Scaptodrosophila lebanonensis

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