Conserved Protein Domain Family
17beta-HSD1_like_SDR_c

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cd05356: 17beta-HSD1_like_SDR_c 
17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
This subgroup includes various 17-beta-hydroxysteroid dehydrogenases and 3-ketoacyl-CoA reductase, these are members of the SDR family, and contain the canonical active site tetrad and glycine-rich NAD-binding motif of the classical SDRs. 3-ketoacyl-CoA reductase (KAR, aka 17beta-HSD type 12, encoded by HSD17B12) acts in fatty acid elongation; 17beta- hydroxysteroid dehydrogenases are isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. 17beta-estradiol dehydrogenase (aka 17beta-HSD type 1, encoded by HSD17B1) converts estrone to estradiol. Estradiol is the predominant female sex hormone. 17beta-HSD type 3 (aka testosterone 17-beta-dehydrogenase 3, encoded by HSD17B3) catalyses the reduction of androstenedione to testosterone, it also accepts estrogens as substrates. This subgroup also contains a putative steroid dehydrogenase let-767 from Caenorhabditis elegans, mutation in which results in hypersensitivity to cholesterol limitation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.
Statistics
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PSSM-Id: 187614
Aligned: 31 rows
Threshold Bit Score: 196.67
Created: 31-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active siteputative NAD(P)
Feature 1:active site [active site]
Evidence:

cd05356 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd05356 is a member of the superfamily cl21454
Sub-family Hierarchy
cd02266SDRcd05226SDR_e_acd05229SDR_a3cd05242SDR_a8cd05243SDR_a5cd05244BVR-B_like_SDR_acd05245SDR_a2cd05250CC3_like_SDR_acd05259PCBER_SDR_acd05262SDR_a7cd05265SDR_a1cd05266SDR_a4cd05267SDR_a6cd05271NDUFA9_like_SDR_acd08946SDR_ecd05193AR_like_SDR_ecd05227AR_SDR_ecd05228AR_FR_like_1_SDR_ecd08958FR_SDR_ecd05230UGD_SDR_ecd05232UDP_G4E_4_SDR_ecd05234UDP_G4E_2_SDR_ecd05235SDR_e1cd05236FAR-N_SDR_ecd05237UDP_invert_4-6DH_SDR_ecd05238Gne_like_SDR_ecd05239GDP_FS_SDR_ecd05240UDP_G4E_3_SDR_ecd052413b-HSD-like_SDR_ecd098113b-HSD_HSDB1_like_SDR_ecd098123b-HSD_like_1_SDR_ecd098133b-HSD-NSDHL-like_SDR_ecd05246dTDP_GD_SDR_ecd05247UDP_G4E_1_SDR_ecd05248ADP_GME_SDR_ecd05252CDP_GD_SDR_ecd05253UDP_GE_SDE_ecd05254dTDP_HR_like_SDR_ecd05255SQD1_like_SDR_ecd05256UDP_AE_SDR_ecd05257Arna_like_SDR_ecd05258CDP_TE_SDR_ecd05260GDP_MD_SDR_ecd05261CAPF_like_SDR_ecd05263MupV_like_SDR_ecd05264UDP_G4E_5_SDR_ecd05272TDH_SDR_ecd05273GME-like_SDR_ecd08957WbmH_like_SDR_ecd08947NmrA_TMR_like_SDR_acd05231NmrA_TMR_like_1_SDR_acd05251NmrA_like_SDR_acd05269TMR_SDR_acd089485beta-POR_like_SDR_acd05233SDR_ccd05322SDH_SDR_c_likecd05323ADH_SDR_c_likecd05324carb_red_PTCR-like_SDR_ccd05325carb_red_sniffer_like_SDR_ccd05326secoisolariciresinol-DH_like_SDR_ccd05327retinol-DH_like_SDR_c_likecd09807retinol-DH_like_SDR_ccd09808DHRS-12_like_SDR_c-likecd09809human_WWOX_like_SDR_c-likecd09810LPOR_like_SDR_c_likecd053283alpha_HSD_SDR_ccd05329TR_SDR_ccd05330cyclohexanol_reductase_SDR_ccd05331DH-DHB-DH_SDR_ccd0533211beta-HSD1_like_SDR_ccd05333BKR_SDR_ccd05334DHPR_SDR_c_likecd05337BKR_1_SDR_ccd05338DHRS1_HSDL2-like_SDR_ccd09762HSDL2_SDR_ccd09763DHRS1-like_SDR_ccd0533917beta-HSDXI-like_SDR_ccd05340Ycik_SDR_ccd053413beta-17beta-HSD_like_SDR_ccd05343Mgc4172-like_SDR_ccd05344BKR_like_SDR_likecd05345BKR_3_SDR_ccd05346SDR_c5cd05347Ga5DH-like_SDR_ccd05348BphB-like_SDR_ccd05349BKR_2_SDR_ccd05350SDR_c6cd05351XR_like_SDR_ccd05352MDH-like_SDR_ccd05353hydroxyacyl-CoA-like_DH_SDR_c-likecd05354SDR_c7cd05355SDR_c1cd0535617beta-HSD1_like_SDR_ccd05357PR_SDR_ccd05358GlcDH_SDR_ccd05359ChcA_like_SDR_ccd05360SDR_c3cd05361haloalcohol_DH_SDR_c-likecd05362THN_reductase-like_SDR_ccd05363SDH_SDR_ccd05364SDR_c11cd053657_alpha_HSDH_SDR_ccd05366meso-BDH-like_SDR_ccd05367SPR-like_SDR_ccd05368DHRS6_like_SDR_ccd05369TER_DECR_SDR_acd05370SDR_c2cd05371HSD10-like_SDR_ccd05372ENR_SDRcd05373SDR_c10cd0537417beta-HSD-like_SDR_ccd09805type2_17beta_HSD-like_SDR_ccd09806type1_17beta-HSD-like_SDR_ccd08929SDR_c4cd08930SDR_c8cd08931SDR_c9cd08932HetN_like_SDR_ccd08933RDH_SDR_ccd08934CAD_SDR_ccd08935mannonate_red_SDR_ccd08936CR_SDR_ccd08937DHB_DH-like_SDR_ccd08939KDSR-like_SDR_ccd08940HBDH_SDR_ccd089413KS_SDR_ccd08942RhlG_SDR_ccd08943R1PA_ADH_SDR_ccd08944SDR_c12cd08945PKR_SDR_ccd09761A3DFK9-like_SDR_ccd11730Tthb094_like_SDR_ccd11731Lin1944_like_SDR_ccd05274KR_FAS_SDR_xcd08952KR_1_SDR_xcd08953KR_2_SDR_xcd08954KR_1_FAS_SDR_xcd08955KR_2_FAS_SDR_xcd08956KR_3_FAS_SDR_xcd08928KR_fFAS_like_SDR_c_likecd08950KR_fFAS_SDR_c_likecd08951DR_C-13_KR_SDR_c_like
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
Q5XG41      54 GKWAVVTGATDGIGKAYAEELARRGMSIVLISRSp--eKLDEAAKHIKETfk-veTKIIAADFg----kPTEIYERIeag 126  African clawed frog
XP_804590   45 GDWAIVTGATEGIGYAMAMELARRGFNVCVVARTr--sKLDAVVAEIEKKgv--qGKAVVFDFst---aDAQAYKRLfae 117  Trypanosoma cruz...
XP_649970   50 NTYAIITGAAGGIGKAFAEKFAKEGFNLIVIARRe--eILKQMKQEFEEKyq-inVKVIANDLis--idENNQWNKIene 124  Entamoeba histol...
AAG28906   917 GSWAIITGPTDGIGKAFAFQLAQKGLNLILVARNp--dKLKDVSDSIRSKysqtqILTVVMDFsg---dIDEGVKRIkes 991  thale cress
A8N6B4      63 GAWAVVTGATDGIGKEFAMQLGKAGFNVLLVARNp--aTLAATAGEIEQKyk-vqTGTFSIDFaa---aTEEKYTALgev 136  Coprinopsis cine...
A8Q1U2      49 GSWALVTGATDGIGREFAMQLAARGFNIVAVSRTa--eKLAILSKEIESTmpgikTCYYAMDFls---aGNAEYEGLeql 123  Malassezia globo...
Q4P622      75 ASWAVVTGATDGIGREFALQLARKGFNIVLVSRSp--eKLGSVAAEIEAAtpgvrTKTQAIDFal---gDERQYEGLeht 149  Ustilago maydis 521
Q5KC11      75 ETWAVVTGCTSGIGLEFARQLAAKKFNIILVGRRq--sALTDLSKEIESKyd-vhTKSVTVDVstpgsaRDDALTQLell 151  Cryptococcus neo...
Q10130      88 HRWTVVSGGTDGIGKAYTLELAKRGLRKFVLIGRnp-kKLDSVKSEIEEKhsdaqIKTFVFDF------GSGDFSSLrdy 160  nematode
Q11177     503 DTWTVITGGTDGIGKAYIEELCKTRGLKKFYLIGrnidKLNNTKKELVEQhg-ceVMCHVHDF------EKDDLSALpkd 575  nematode
Feature 1                                                 #                             #      
Q5XG41     127 lrdlEIGVLVNNVGVSYe----YPEYFLEipdlentLDKMININIMSVCQMTRLVLPGMl--gRGKGVILNISSASGm-- 198  African clawed frog
XP_804590  118 lellEVAILVNNVGVNYp----YANYFDDadv--eeDMKMLKVNCEATLRMTRFIVPRLk--aKRSGGIVFLSSISAt-- 187  Trypanosoma cruz...
XP_649970  125 lkgiDIGVLVNNVGMCQy----LPGKFGDvdi--kdINNMVSLNIRVLTMLTHIIIPMMle-rKEHGLIINMSSATSs-- 195  Entamoeba histol...
AAG28906   992 ieglDVGILINNAGMSYp----YAKYFHEvde--elINNLIKINVEGTTKVTQAVLPNMl--kRKKGAIINMGSGAAal- 1062 thale cress
A8N6B4     137 ltglDVGVLVNNVGKSHn----MPAYLVDtpr--deMRDIVEINVNATLRVTYAILPGMv--kNKRGLILNIGSFAGa-- 206  Coprinopsis cine...
A8Q1U2     124 irhlDIAVLVNNVGLSHt----MPVNFLEmdg--reLASICQVNIVATMQVTRVVAPHLv--rRGRGLILNLGSFSGq-- 193  Malassezia globo...
Q4P622     150 vkglNVGVLVNNVGKSHn----MPVTFTEtse--eeMEDIIEINVVSVLRVSKMIIPGMv--dRKRGLVLNLGSFAGq-- 219  Ustilago maydis 521
Q5KC11     152 aqnlDVGILINNVGASHs----MPVAFHEter--seMSRIIETNVTWTYLVTRSILPSMvarsKQKGAPKSLVITIGsls 225  Cryptococcus neo...
Q10130     161 isdiDVGFVVNSVGTGRdnlerYGDNPDE-------DTQILRVNGMGAAEFLSCVLPPMe--kSGGGQIVVLSSSQGv-- 229  nematode
Q11177     576 letlDVGILINCAGIAPh----IIGTLTElpe--glASKILRVNLMSAVKMTEMILPNMv--kKKRGIIVNISSMTGwrr 647  nematode
Feature 1                   #   #                                                              
Q5XG41     199 -----yPVPLLTVYSATKAFVDFFSRGLHAEYrnkGINVQSVLPFYVATKLAKir-----kPTWDKPSPETYVRSAVNTV 268  African clawed frog
XP_804590  188 -----mPSPLLSAYAGTKSLSLSFGEGLAYELqqfGVDVLTVTPSLVVSRMTQgvssrkpkETLFMVNAATMAHQTLNKL 262  Trypanosoma cruz...
XP_649970  196 -----vPFPMFQVYAASKAFIKQFNDSLYAEYk-gKIDCISYCPWYIKTEMTKir-----eSSIYVLEPEEFVEYCFLFF 264  Entamoeba histol...
AAG28906  1063 ----ipSYPFYSVYAGAKTYVDQFTKCLHVEYkksGIDVQCQVPLYVATKMTKir-----rASFLVASPEGYAKAALRFV 1133 thale cress
A8N6B4     207 -----iPSPMLATYSGTKAFLSTFSSALGEEVkkdGIIVENVNTYFVVSKLSKir-----kSSLLIPTPAPYVRSVLSKV 276  Coprinopsis cine...
A8Q1U2     194 -----wSTPLLATYAGSKAFLIAWTQALGEEMrrsHVDVQLLNTYFVVSSMSKvr-----kPSMMVPTPKNFVRSALSRI 263  Malassezia globo...
Q4P622     220 -----vTTPMLATYAGSKAFLSGWSQALGEEVkrsNVDVSLLNTYFVVSNLSKir-----kSSAMIPTPKQYVTQVLKTL 289  Ustilago maydis 521
Q5KC11     226 ---griPSPLLASYSGTKAALATWTKALAEEVkpqGVIVELVQAAFVVSNMSKir-----kSSPFVPTPAPFVRSTLNSI 297  Cryptococcus neo...
Q10130     230 -----rPIPMLAAYCATKALMTFLCESIDREYs--TINVQTLIPALVATKMTYyt-----kGSTFVVTPENFCHQAVGSI 297  nematode
Q11177     648 frtsvlTRLAKLHYPSSPTPCQMNTEELEFVFs--VSFQCSLLPRSPRMKLKKrt-----iSSLSPLKTLPNKLSELSGL 720  nematode
Feature 1                                                
Q5XG41     269 Glq-------------tQTNGYLPHAIMGWi--sTSLVPVSV 295  African clawed frog
XP_804590  263 Gtv-------------tRTAGHINHALLNSc---LRILPESL 288  Trypanosoma cruzi strain CL Brener
XP_649970  265 Gqq-------------nHIDPYWFHYLMDIg---AWLYPTDT 290  Entamoeba histolytica HM-1:IMSS
AAG28906  1134 Gye-------------aQCTPYWPHALMGAv---VSALPESV 1159 thale cress
A8N6B4     277 Glacgaa----fsgrpnTSTPYWSHALLDYam-tLVGIPSLF 313  Coprinopsis cinerea okayama7#130
A8Q1U2     264 Grssga------lgrpfTLTPFPSHAWLDWa--vEHFVPRWW 297  Malassezia globosa CBS 7966
Q4P622     290 Grngga------vgrpyTATPWPGHALVDWa--tTFVLPRGW 323  Ustilago maydis 521
Q5KC11     298 Glprga------qgrphERTPFWSHAILDYvvgfAGYVSEMA 333  Cryptococcus neoformans var. neoformans B-3501A
Q10130     298 Glt-------------kKTAGCLNHELQMLg---FHLFPWTI 323  nematode
Q11177     721 IgksqravcnmmfrlplEHCSPFGFSKYFSs---LLLCSEFI 759  nematode

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