Conserved Protein Domain Family
Rab3-GTPase_cat

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pfam13890: Rab3-GTPase_cat 
Rab3 GTPase-activating protein catalytic subunit
This family is the probable catalytic subunit of the GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). It is likely to convert active Rab3-GTP to the inactive form Rab3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. This complex interacts with DMXL2.
Statistics
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PSSM-Id: 464022
Aligned: 43 rows
Threshold Bit Score: 154.718
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002292469 1831 HNHNRVGARCP---VpDVLPLIETG-DQLYAPYLQRTMPVTDEEEEKQKKLLgVSRKDEDekrvsiQSriaisQRLQKPK 1906
CRZ25820      606 DSSGAEGRLKP---F-GTLRLIHYPdRLMYEPVTQTRVPVTEDMLEKHAEYL-ASLKDPE------ER-----VKAQLEP 669 
XP_001466186  810 EENVAATSLTA---S-PVRYLITNG-EVLCVPPPLPQPPTTADEVVKRAVEL-NSLDATAves-------asvEWLQTDA 876 
Q4DXS5        602 EASAADGECSAdgfLiSGKCLITNG-EPLVEPKALPTPPCTSDVMMMKAQEL-QNLGTESag--rhTR-----AWIQSEG 672  Trypanosoma c...
ERN17415      371 RLVLRLGADHP---S-ENLTMLETG-EPIYSPRTQEGPLFTEDLLKETEEIV-LRTGS---------------FGTGCSQ 429 
CBI26658      367 ELVLRLGAGRP---S-DNLMMLETG-EPIYVPVTQEGPLLTEDLIKETEEFV-LRTGS---------------VGAGCSQ 425 
KRH14372      373 ELVLRLGADHP---A-GDMTLLETG-EPVYSPITQEGPLLTEDLIRETEEFV-LRTGS---------------VGAGCSQ 431 
Q683D2        356 ELILRLGVYNQ---V-ENLTMLETG-EPVYSPITQEGPLLTEDLIRETEELV-LRTGS---------------MGAGCSQ 414  thale cress
XP_002963602  419 QVVPRYCVDRR---A-ENLIMLETG-EPIFSPVTQEGPVLTEELIKETEELV-LRTGS---------------FGAGCSQ 477 
EEC45430      911 QVRERKGARCP---M-KNINLLETG-DQLYAPYLQRPYPLTDDVITQRRMML-LKQKSSGkasstvLRrmevaHLLQKPK 984 
XP_002292469 1907 LLSDMSSFK---AANQGAV--FEDFVRWYgNPQNPLSEEVNGETarraaqyrsklppeeakvlalEEASEAIAilmSLR- 1980
CRZ25820      670 LFSDMEAFK---AANPGCC--FEDFVRWH-SPRDFIVNDENTGE---------------------GCLSSRMT---GEG- 718 
XP_001466186  877 LYNDMCFFLyvnKAHEGRIvrFPDFVQWH-SPRDFVASAGAESTtspsverp------srslsdnDYLSERMQ---RQQk 946 
Q4DXS5        673 LFNDMCLFLyfnRAQEGRVvrFPDFVQWH-SPRDFIPPLCDSKEkkd---------------dddAYLSERMR---RHSn 733  Trypanosoma c...
ERN17415      430 LFSDMQAFK---AANPGCI--LEDFIRWH-SPPDWTEGDTNNADknylee---------dgswkrGQLSTRMQ---KEG- 490 
CBI26658      426 LLSDMQAFK---AANPGSI--LEDFVRWH-SPPDWTDT-EPSDEfkdtfdg-------gdslsarGQLSSRMR---KEG- 487 
KRH14372      432 LLSDMQAFK---AANPGCI--LEDFVRWH-SPPDWTDN-EASTEdsdvfds-------geplsarGQLSRRMQ---KEG- 493 
Q683D2        415 LLSDMQAFK---AANPGCI--LEDFVRWH-SPPDWTENGNMSGDdss---------------pvrGQLSTRMQ---KEG- 469  thale cress
XP_002963602  478 LFSDMQAFK---AANPGCI--LEDFVRWY-SPLDWTEENPVGKGdep---------------slrGSLSTRMR---SEG- 532 
EEC45430      985 LLSDMQAFK---AANPNAI--FQDFVNWYgNPRDPLEEyeeslslalrp------gtsdtietklDKAKEGIYvlsMTR- 1052
XP_002292469 1981 -----------AFWEDSWDEAEP-CPAFEQEPLFDPYSTVEMVFHSFE 2016
CRZ25820      719 -----------NTWQQTWNRAQL-KPAYRQKLLFDDLKAANKIISDFE 754 
XP_001466186  947 ecgasggkgsaHVWWSLWRRATPrSRDDIVHGLFQPLEQATKILAWLA 994 
Q4DXS5        734 aen-----glvNIWWPLWERATPrSPEEIIAQSFVPHEQARLIIRWME 776  Trypanosoma cruzi
ERN17415      491 -----------NLWRELWENAKP-LPAVKQTPLFDEDLAVESILNYLE 526 
CBI26658      488 -----------NLWCELWKTAKP-LPAVKQAPLFDEDLAVEGILHFLD 523 
KRH14372      494 -----------NLWRELWETSKP-VPAVKQAPLFDEDLAVEGILNAFE 529 
Q683D2        470 -----------NLWRELWETAKP-LPAVKQAPLFDEDLAVEGILNYLE 505  thale cress
XP_002963602  533 -----------NLWQELWLSARP-VPAVMQAPLFDEELAGESTLEALE 568 
EEC45430     1053 -----------DFWTGTWKEAKP-LSASFQEPLFDATMTVEMMLDFLE 1088
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