Conserved Protein Domain Family
DLC-like_TCTEX1D4
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cd21461: DLC-like_TCTEX1D4 
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins
Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.
Links
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Statistics
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PSSM-Id: 412009
Aligned: 13 rows
Threshold Bit Score: 167.528
Created: 28-Jan-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5JR98       108 YRTEPVPGERWEAARAQRALEAALAAGLHDACYssdeaarLVRELCEQVHVRLRELsppRYKLVCSVVLGPragQGVHVV 187 human
XP_006006300 118 YKTQPDQGCKFDASRVQSILEAALATHLAEVRYnqvtssqLTQRLSEIIRSKVKEAtppRYRLVCQVILGQrkdQGVRIA 197 coelacanth
XP_018116330 124 YKTGPDNGCRFTPQRVQQVLEATLSSYLGDTKYspltcgqLSQSLAELIRSKVKDLipsRYKVVCNVILGQmgqQGIKVA 203 African clawed ...
XP_007898132 127 YKAQPDEGCKFDTGKVQKLLENMLSSYLADSKYspltsgqLAQGLSDFIRLKVKDVnapRYKLVCHVVLGQlsdQGLHIV 206 elephant shark
XP_005171408 117 YRTGPEPGCRFSARRTQQILQATLDAYLEGVCYsadscsqLCQMLADLVLSKLKDVnppRYKLVCQVVVGQsgdHGVRLA 196 zebrafish
XP_004936791 112 YRMRPEEGCRFNAGRVQRVLEGALAGVLGGTAYspqgstvLVQSLAELLRSRAKEVvppRYKLVCHVLLSQqgqQSMLVA 191 chicken
XP_007480320 105 LGPGPAPGARWEAAQVQQALEALLSGALGGAHYsaggagaLARGLCELVRRRIKELlppRYKLVCTVVVGQcagQGVRVA 184 gray short-tail...
RXM29270     126 YKTHPDEGFRFDACKVQHLLEATLAGFLSDTRYnpvtcgqLTQNLSDLIHSKAKDLnppRYKLVCHVILGQlnnQGLRVA 205 sterlet
XP_024292213 123 YKTEPEKGCLFKASKVQKLVQAMLDSYLDGASYnaasgshLSQILSDMVKNKVKEMsppRYKLVCQVVVGQnrnQGLRVA 202 Chinook salmon
XP_028834015 123 YCLEPEPGCAFNASQTQLILQATLDSYLNGAQYspnscsqLSQVLAEVVRAKVKDVcpsRYKLVCHVAVGQtgdNSFLMA 202 denticle herring
XP_012681175 119 YRMGPDPGNTFSTSRTQQILQATLDSYLDGARYnsntcsqLSLILADLVRGKIKDTcppRYKLVCQVVIGQnsnQSLAVA 198 Atlantic herring
KPP70723     138 YKTGPDDSCRFDANHIQQILQSTLDGFLGDALYsaaaggqLSRTLSERLRSQIRDIslpRYKLISFVVVGQcsnHDLQVA 217 Asian bonytongue
XP_008107745 121 YKTQPDEGCKFNSSQTQQLLESVLASYLRDAKYnptnsgqLAQNLSDLIRSRVKDLsppRYKLVCNVFLGQqakQDLHIA 200 green anole

Q5JR98       188 SRALWDvARDGLASVSYTNtSLFAVATVHGLYCE 221 human
XP_006006300 198 SRCLWDpENDNFATASYTNaSLFAVVTVHGLYYE 231 coelacanth
XP_018116330 204 SRSLWDpQNDNFASATYANsSLFAVALVHGVYYE 237 African clawed frog
XP_007898132 207 SRCLWDtSTDSYAAATYRNsSLFAVATVHGVYFE 240 elephant shark
XP_005171408 197 SQSLINpNTDNYTSAVFQNhSLFAVAVVHGVYYE 230 zebrafish
XP_004936791 192 SRALWDpESDSFASASFCNaSLFAVATVHGVYFE 225 chicken
XP_007480320 185 SRALWDaSSDGYASASVCAaAFFAVAVVHGVYCE 218 gray short-tailed opossum
RXM29270     206 SRCLWDsDKDNFAVATFQNtSLFAVAMVHGLYCE 239 sterlet
XP_024292213 203 SRCLWDsQHDDFAVAMFQNhSLFTLVIVHGVYCE 236 Chinook salmon
XP_028834015 203 SRCLHDsERDNFASAAFQNnSLFAVVVVHGLYFE 236 denticle herring
XP_012681175 199 SRGLLDsSRDDFAAATFQNnSLFTVAVVYGSYYE 232 Atlantic herring
KPP70723     218 SRCLWDtQTDSSAVAVFQNsSLFAVAIIYGVYFE 251 Asian bonytongue
XP_008107745 201 SRSLWDvENDNFASAAFTNtSMFAVATVHGLYFE 234 green anole
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