Conserved Protein Domain Family
Serendipity_A

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pfam05482: Serendipity_A 
Serendipity locus alpha protein (SRY-A)
The Drosophila serendipity alpha (sry alpha) gene is specifically transcribed at the blastoderm stage, from nuclear cycle 11 to the onset of gastrulation, in all somatic nuclei. SRY-A is required for the cellularization of the embryo and is involved in the localization of the actin filaments just prior to and during plasma membrane invagination. This family forms a different clade of the Vinculin superfamily with an evolutionary relationship that is functionally consistent with a role for sry alpha at the actin cortex during cellularization.
Statistics
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PSSM-Id: 368466
Aligned: 7 rows
Threshold Bit Score: 846.009
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q07964         1 MESLLRQLSICNELIA-QGpacpVGNIAWLNEFCATFLDFASELKAHLPEIAPRWgAPEGGNNIEVETIFLCLTQVVTCI 79  Drosophila pseu...
XP_001964546   1 MDSLLTQLNMCSELIA-EG----TCNMGWLNEFCATFLDFASELKGKLPDISPRW-PLESGDSLEVETIFLCLTQVVTCI 74 
P07666         1 MEQLLAQLHTCSELIA-EGys-sTGNIGWLNEFCATFLDFASDLKARLPEVAP------SGANLDVETIFLCLTQVVTCI 72  fruit fly
XP_002072934   1 MEQLLQQLNLCNELIEvKGe---KGNIKWLNRFCATFLKFASEFKIYLPEVAPKY-TTESSTDLHVETIFLCLTQVVTCI 76 
EDV93198       1 MDILFIKLNVCSDLIG-KGa---IGNIAWLNKFCAAFHEFASKFKMHLPDVAPKD-DMEGKIRIHVETLFLCFIQVVTCI 75 
XP_002056142   1 MDKLYLQLNVCTDIIA-KGatchTAKIAWLNEFCAAFHTFASKFKSYLIELAPKN-ELEGNIRIHVETIYLCFTQVITCI 78 
XP_001998873   1 MDKLFLQLNVCTELIE-K-----FTNIESLNRFCATFHKFASKLKNFL----PKT-DVDGYSKIHIETIYLCFTQIISCI 69 
Q07964        80 TQLERTINIESkfghettP-MTRLHFLDRIDWCVRRIYVSLSQLDLHQESGAadNLEDHTFVELMDLALDHLEAFMEGLG 158 Drosophila pseu...
XP_001964546  75 THLERAINVEA-------SqMSHHHFLDRMDWCLRRLLDSLTQLSLHQDEAK--KLEDQSFVELLDLALDHLENYLEKLN 145
P07666        73 THLERTISMEA-------PhMTRQHFLDRLDWCLRRLLVSLTQLEGNVTPVK--NLEDHSFVELMDLALDHLDDYMEKLA 143 fruit fly
XP_002072934  77 THLERIINIEEatt--ssYlMTRQHFVDRILWCIRRLFASLNELMEDETTL---DLEDLTFVELMDLALDQLESHREEMK 151
EDV93198      76 TQLERTINMENtlgkrvkLrLTRTHFVDRIEWCLRRLQASLYHLSEEAIASSgvKLEDLSFVEVLDVALDKLETFNEIVH 155
XP_002056142  79 TQLERTINIEGtlaagaqLlATRTHFLDRIDWCLRRLQASVYQLAEEAIASTpvKLEDLSFVELLDLALDKLETYSEIVP 158
XP_001998873  70 TQLERTINIEDsgg--spLlATRTHFRDRIEWCLRRLQASIYQLNEEAIASTpvKLEELSFVELLDLALDKLESYSDIVE 147
Q07964       159 NTTSNFLYIEEEndtNDACQLGSIINHIVRHALAFANVALEADKKALSELCETLLSECTTFLEGSAELNPGHRKLEALSL 238 Drosophila pseu...
XP_001964546 146 EKDNNCLGIEED---EEGYQLASIVNHIVRHALAFANVAIKSDKKALSALCETLLSECAIFHEDAGDPNNGHRKLEALSL 222
P07666       144 QQRNNSLHILEEsftEDTYQLASIVNHIVRHALAFANVAIHSDKKALTALCETLLAECATFHEEAGEPNSGHRKLEALSL 223 fruit fly
XP_002072934 152 PNGTYSILPVEAnekKDNYELSELASHIVRHALAFANVALEPDKRALTTLCETLLSECKAFRENVEDQTPEERKLEALNL 231
EDV93198     156 DVDT------ESrldSENPQLCIEVNHIVRHALAFANVALESDKKAMTVICETVLDECSVFEHNFDHHNLGERKLEALSI 229
XP_002056142 159 AQSQ-----AEQedsDEIDQLVDHVNHLIKHALAFANVALESDKKALSAIYETVLEESGIFEKNFKTHNPNERKLEALSL 233
XP_001998873 148 EEQD------DLfdaREHLQLVDQVNHIVRHALAFANVALESDKKALTAICETVLDECVTFEKNFENYNRNERKLEALSL 221
Q07964       239 ERALYGLETFLNEALLHSIFASLVELENTPINRLRHALQEQESESgltEKLVSDFDTNMDRIQQIGVLAIAFSQDVKTKT 318 Drosophila pseu...
XP_001964546 223 ERALYSLESFLNEALLHLLFVSWNELENNPVKKLKDVLKTDSDDA---QELISAFDTNMDRIQQIGVLAIAFSQDIKTKT 299
P07666       224 ERALYALESFLNEALLHLLFVSLIDLENASVEKLKDALQRDPAGA---QELISAFDTNMDRIQQIGVLAIAFSQDIKTKT 300 fruit fly
XP_002072934 232 ERALYSLEGLLNEALLRLV--CLLDVEETSVKKLKQILGECNDNSt-vDQLICDFDIKMDRIQQIGVFAIAFSQDVKTKT 308
EDV93198     230 QRALYSLETYLNEALLRLIFTSFSDADEISVNRLKNVLQKCEISKd-vEKRICDFDINMDRIQQIGVFAIAFASDVKTKT 308
XP_002056142 234 QRALYSLETYLNEALLHLIFTSMFDTEKASIKRLRNVLQSCESSGa-vDGLVSDFDINVDRIQQIGIFAIAFTQDVKTKT 312
XP_001998873 222 QRALYSVETYLNEALLRLIFNSL--GETSYISELKNALQQSESSAd-vEKLICDFDINVDRIQQIGVFAIAFTPDVKTKT 298
Q07964       319 IVRSCLASLESLDACIVPALQ----SSA--LHHADILEHHFNDEMLIFRNLIHDIIDSRSLVNNYLDMLAESLHihiagk 392 Drosophila pseu...
XP_001964546 300 IVRSCLASLESLDACIVPALQvqhsPAS--EKYADILEQHFNEELLIFKNVIHEIIDSSSLINNFLDMLGESVH------ 371
P07666       301 IVRSCLASLESLDACIVPALQlpesTSS--AHHAEVLQEHFNQELLIFRNVIHEIIDSCSLINNYLDMLGERIH------ 372 fruit fly
XP_002072934 309 IVRSCLASLESLDACIVPAFKlqrsATSttLHHANILEHHFNEELRIFWNVLHEIIDSQSLVNNYLDMLVQKIHg----- 383
EDV93198     309 IIRSCLASLESLDSCIVPAFQlqtsTSA--SYHANILEHHFKEELMVFRNVIHEIINSRALIDIYLDMLAESIDga--ek 384
XP_002056142 313 IIRSCLASLESLDACIVPAFQlqttSSA--SYHADILEHHFRQELMVFRNVIHEIIDSRALINNYLDVLAESIDna--ek 388
XP_001998873 299 IIRSCLASLESLDACIVPAFQfqatTSA--LYHANILENHFKEELLMFRNVVHEIIDSRALISNYLDILDESIDna--at 374
Q07964       393 SVPREYLL-IVQMGSVLAEHFRLPVNYSAL--SDDGKRVHKDLILILRECLAAVSLATPVDPKRIVKRLKILYSVLAKLR 469 Drosophila pseu...
XP_001964546 372 IQEKSHLKlIIQMGNVLVEHFRLPVNYGGL--SKDGKRVYNDFIVILRECHAIINLKIPVDPKRIVKRLKILYSILAKLR 449
P07666       373 VQDKSHLKlIVQRGGVVVDHFRLPVNYSGL--SEDGKRVHKDLILILRECQAVVNLDVPVDPKRIVKRLKILYSVLAKLR 450 fruit fly
XP_002072934 384 ATTKEHHK-VVQMANVLLEHFGLAVNYDAL--DEVGKRLYNDFQLILRECKAILKHPIAIDPKRILKRFKILYSILAKLR 460
EDV93198     385 LYQKQRLLqVAQMGNVLFQHFHLKVNYQELcaDECGKRLHQDFVVILGECQAILELTVPVDPKRVLKRFKILYSVLAKLR 464
XP_002056142 389 LYPKGYLLqVAQMGNVIYQHFQLRANNQELiaDEEGKRLHQDFLAILHECQAVLEISVHVDLKRIIKRLKILYSILAKLR 468
XP_001998873 375 LYPKGHLLkVSQMGNVLFEHFQLKVNYQELteDVEGKRLHQDFIAILRECQAVLEISIQVDLKRIIKRLKILYSVLAKLR 454
Q07964       470 DVIDKNVHDSVFNLssr-rqiTNATRTLLRSCKSKSKR--QRSYVKQSQDSVVPDPhnytsSIANSISNDGDLISFQLTE 546 Drosophila pseu...
XP_001964546 450 DIINKDNQEADESFlspkpiaCNATRTIARNSRSNSRR--QRTSIKQKTETFIQEE-----SLADSKWNESDLISFQITE 522
P07666       451 DLICRDNLEPDSSVaseaqvpSSATRTFVRSSRSFGKR--HRSFVKQTGNCSVFGPq---dSLAESGHSESDLISFQITE 525 fruit fly
XP_002072934 461 DVLGKSKDTEVFN------------GSCLESNQSASKR--QRSFFKPHQ-----SRqqnvtTTLNSANNDSELLSFQLTE 521
EDV93198     465 DVCGGSIREGSVCp-------NQNSHMISKNLKHNSIR--QQTFVKPGKEFTHDKSsnnksS--NSLLHESDLISFQITE 533
XP_002056142 469 DVCDKLVYERAMS---------NNEKSMTTSTK---LR--QHSFANPEIGHTIANCnrtdsS--DSLSHESDLISFQLTE 532
XP_001998873 455 DVCDRLVYQRSVC---------KNEKSMTTSTQ---LRnaSQSFTNPERGNTIVNr----sS--TSLNQESDLLSFHLTE 516
Q07964       547 ILRIN 551 Drosophila pseudoobscura pseudoobscura
XP_001964546 523 ILKLN 527
P07666       526 ILRLD 530 fruit fly
XP_002072934 522 ILRIg 526
EDV93198     534 ILQIN 538
XP_002056142 533 ILRIT 537
XP_001998873 517 ILRIT 521
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