Conserved Protein Domain Family
THUMP_THUMPD1_like

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cd11717: THUMP_THUMPD1_like 
THUMP domain-containing protein 1-like
This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.
Statistics
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PSSM-Id: 212586
Aligned: 95 rows
Threshold Bit Score: 66.0678
Created: 25-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGX49621      19 GIFATCDkgRESRCVAELYRLFeeyadklygpedagtadsadnqnpnepedkpdvddieaaiaaeisginakgkakdnri 98  Arthrobotrys ol...
YP_004290545  23 SIYDTYEqiDEIEGIDEIEGALtlrd---------------------------------------------------pel 51  Methanobacteriu...
O26994        14 NLLVTLRgqKGETAGEEIVGLEetemals---------------------------------------------ryegel 48  Methanothermoba...
NP_376355      5 KLILTVKnnKNNKCIIEILNRLylk----------------------------------------------------dln 32  Sulfolobus toko...
YP_255558      5 TLLLTAKknKDNICLMEILNRIlikd---------------------------------------------------ina 33  Sulfolobus acid...
YP_004408839  31 ALIATTApnKGSKCRLDLLNRLipc----------------------------------------------------dpd 58  Metallosphaera ...
YP_004519747  15 LLVTFKGh-KNETVGVELLGIEeiela-------------------------------------------------lqng 44  Methanobacteriu...
NP_342279      9 LVTTKPG--KGRKCINEILNRIli------------------------------------------------------kd 32  Sulfolobus solf...
YP_004457708   6 IITTLPG--KDKKCKAEILDRLli------------------------------------------------------kd 29  Acidianus hospi...
YP_001192109  10 LITTAPN--KGNKCRTDVLNRLip------------------------------------------------------yd 33  Metallosphaera ...
EGX49621      99 TSIKLdt---pCLIFFHtk---epVDPAELVGfifkdieetkrrqtRFTNRLTPIt--KTCKa-nITDLEETAHEVLKPH 169 Arthrobotrys ol...
YP_004290545  52 YIKESes---fDVVLVEl-----gTDSLEAAKllrn-------snpRIVSTVIPIr--RVVKt-dLREIGRNLKELAIKE 113 Methanobacteriu...
O26994        49 RVIESdf---pNVMMFDl-----nMDPLEAVNiikn-------sptTVISKVVPVe--AVVRt-rLDSILEKVIALVSEK 110 Methanothermoba...
NP_376355     33 SKAEEii---kNVILVYt-----sLTPIMAYGllis-------appSCLAKIYPVd--LVIHsvkEREIIDKITEFLKKN 95  Sulfolobus toko...
YP_255558     34 TAVEIv----kNVIILYs-----nLNPMEAYGllis-------gppSCVAKIFPIh--GVIDsisEAEVIRKSIDLCKNM 95  Sulfolobus acid...
YP_004408839  59 VLIEEpi---kNVLLVRs------NLPSLLCYgavi------sappACVRKVFPVd--AVTKs-eYKEIMKASVKILENK 120 Metallosphaera ...
YP_004519747  45 DPVYIeetefiNVVLVRvandpldAAMKLMDTq------------tTVISKIVPInevVRTR---PDYIVEKVIMLSGEK 109 Methanobacteriu...
NP_342279     33 IDARViey-vqNVAIVYsnl-dslVVYGLLFAsp-----------pSCAEKVYPFqliINSTn--EKEIVVNVINFIKNK 97  Sulfolobus solf...
YP_004457708  30 ENVQIdei-kqNVFLIYskl-splEAYGLIISap-----------pSCIGRIFTId--KISD---LSNIFEDAEKLLSSK 91  Acidianus hospi...
YP_001192109  34 VEVRIeep-ikNVLLVYskl-psvQCYGLVMSap-----------pACARKVYPVdqvTRAE---YREIITSSLAMLQGK 97  Metallosphaera ...
EGX49621     170 fhegqkgVKFAIRPNLRDhr-vLNRDEIIKSVARIVGPd--hKVDLKNYDLLIIVEVWRNICGVSVVR 234 Arthrobotrys oligospora ATC...
YP_004290545 114 me---pgDDFTVETSVIShk-tIESTDILEKVEDELKEin-mNFDETDPKWKIYVEVIGESTGLNILK 176 Methanobacterium sp. AL-21
O26994       111 ve---agETFRVICDLRGrryiRSAGELVEAVSEALMErf-pITESDEPDWIIQIEVVGDSTGVSVLR 174 Methanothermobacter thermau...
NP_376355     96 iq----fKTFYVDCYDRGi--kINCREVEIGIGIGLRGf--aSVDYKNPEKVIVVNVIKDSTYMSVIK 155 Sulfolobus tokodaii str. 7
YP_255558     96 l-----kNTFYVQCYSRGv--rVNCREIEIGIGIGLRGi--aKVDFKSPELIVFVNVVRDKSYISFLK 154 Sulfolobus acidocaldarius D...
YP_004408839 121 e------GNLYVECIKRSg--nLDCRTIEIAIGGLFSKk--lKIDSKNFHIKLTINILGDITALSLLK 178 Metallosphaera cuprina Ar-4
YP_004519747 110 tn---pkESFVVRCDLRGrkyiKSGEELIDTVSEEIVEklnlKLNEKNPDWVVQIEVVGEDTGVSVLR 174 Methanobacterium sp. SWAN-1
NP_342279     98 tk---dlKTFYVRCYNRGi--dVNCREIEMGVGIGLKGl--iNVDFKDPEVVLHVNVLKEFAGISLLR 158 Sulfolobus solfataricus P2
YP_004457708  92 k-----fKKFYVECINRGnk-qADCRSIEIGIGLRMKGk--lQVDYKNPDYILFVNLIGNKVYLSIMR 151 Acidianus hospitalis W1
YP_001192109  98 g------GSVYVECILRSg--nLDCRTLQMALGGYLRDk--fKIDSKNFNLKLSINVLGEICTISLLR 155 Metallosphaera sedula DSM 5348
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