Conserved Protein Domain Family
SET_SMYD5
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cd10521: SET_SMYD5 
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins
SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.
Links
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Statistics
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PSSM-Id: 380919
Aligned: 17 rows
Threshold Bit Score: 393.982
Created: 25-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 binds H3K36M peptide and SAM.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ###                #                                                  
Q6GMV2        22 SVEVRFVSsaKGKGLFATQlIRKGETIFVErPLVAAQFLWNALyryracdhclralekaeenaqrltgkpgqvlphpelc 101 human
XP_013390066   3 HVEIRVDKl-KGRSLFAVKdFKKGDILFEEtPLVCSQFEWNALykylacdhcmkslenaedmsrrlaanpslvlpfpqcc 81  Lingula anatina
OWF55049       8 NVEIRQIDlsKGKGLFASKdFKKGDILFEErPIVSSQFLWNEFykytaceyclksletaeeqcqrltenpgvnlpypecc 87  Yesso scallop
EDO34962       7 GFIVKETDseRGRALFASRdFKEGDTIFEEdPLVCSQFLWNAAysytacdhcmrsletaqdmarrlssnptlelpysaec 86  starlet sea ane...
XP_011665824   6 IVNVRFIDelKGRGLFASRdIAAGTVLFEEkPLVCAQFLWNECyhyeaceycmrsmenaeemarrlsanpslvlpcmecc 85  purple sea urchin
XP_002735533  13 EIEVRIADdrKGKGVFAKQrFRKNDVIFREkPIVCAQFLWNEYykysacdhcmksletaeemarrlsaisslvlpypqcc 92  Saccoglossus ko...
KFM65223       7 RVEVRVIDeeKGKGLFALRkFSPGDVIFEErPLVCAQFLWNQAygylacdycmrpletaeenvrrltgmqelhlpypecc 86  Stegodyphus mim...
ESN95592       4 CYEIRITQakKGRGMFSRRfIKAGEEIFLEsPMVSVQFAWNETckykacqqclrsmetaeqmyrrltnkphftlpksnlc 83  Helobdella robusta
KJE96973      68 HVQVRVEDarKGRGLFATQaFKKGDIVFTEaPLVCAQFLWNEAygykachqcmrslespgemaarlatapttvvaagsav 147 Capsaspora owcz...
EDV22754      14 PVEVKYINnaRGKGLFATNcFNEGDEIFKEnPLVCAQFLWNEFykyeaceyclrsledaetmarrlsgnpnvvlphkeyc 93  Trichoplax adha...

Feature 1                                                                                        
Q6GMV2       102 tvrk---------------dlhqncphcqvmycsaecrlaateqyhqvlcpgpsqddplHPLNKLQEAWRSIHYPPETaS 166 human
XP_013390066  82 kvkk---------------eehtvcphckvlycsdgcrdsawhlyhrvlcqgasvadpnHPTEKLKDAWRNMHYPPETsS 146 Lingula anatina
OWF55049      88 eakp---------------tqyvmcpqcqvvyccdecrmaawteyhrtlcmgpsrqdgeHPLARLGEAWRNTHYPPETsS 152 Yesso scallop
EDO34962      87 cavtk------------agepisycpqcnvaycsencrikaldqyhrilclgtstpdpnHPLVKLQETWKNIHYPPETaN 154 starlet sea ane...
XP_011665824  86 kaek---------------qnfvhcphcrisyccsecreqawnqyhqvlclsqhppdpnHPLVILQEVWKTMHYPPETtS 150 purple sea urchin
XP_002735533  93 evkk---------------dehvscpacqtqycstkckedaeklyhrvlcmgqhpadpeHPIAKLQDIWRNMHFPPETaS 157 Saccoglossus ko...
KFM65223      87 atkk---------------edyvecpycevsycnsdcraqaweqyhqvlctsslfgntqHPLDQLQDAWRQMHYPPETaS 151 Stegodyphus mim...
ESN95592      84 evt-----------------pdrhvccpdcgapyccrecyeeatalhhkvlctgkdgkdHPTSHLIETWKTMHYPPETfN 146 Helobdella robusta
KJE96973     148 akprtpfelpfmdqcnltiatqqdivtcetcslvfcnaacrdaameshhrilctrndadHPLQLLQSAWKSIHYPPETtS 227 Capsaspora owcz...
EDV22754      94 styam-------------enyvkcprcqvtmycsstclekavkeyhrslccgsnncrpdHSLNRLRETWRNIHYPPETsS 160 Trichoplax adha...

Feature 1                                                                                        
Q6GMV2       167 IMLMARMVATVKQAKDKdrw---irlFSQFCNKTANEEEEIVHKLLGDKFKGQLElLRRLFTEALYEEavsqWFTPDGFR 243 human
XP_013390066 147 IMLIARMIALVKQCDKKdqi---lskFAEFCKSTVNEEEHIAHKLLGKEFQEQLEiLRSLVCEAFYDEhvqqWFTPEGFR 223 Lingula anatina
OWF55049     153 IMLLAKMIAMVKQVDDKssv---isaFSQFVNLPVNKEEEIAHKLLGENFKQPLElLRQMLTESLFEEnvqqWYTPEGFR 229 Yesso scallop
EDO34962     155 IMLIARIMATILQATNSdvk---kgsFSHFCSNVVNKEQQIAHKLLGLHFQEQLDmIRILLSEAMYDDrleqWFTPEGFS 231 starlet sea ane...
XP_011665824 151 IMLIAKMIASIKQAKSKeei---lasFNQFCHVPQNEERQLSHKLLGKQFEGQYEaLQPLLLNALHEEsvaqWFTPGGLR 227 purple sea urchin
XP_002735533 158 IMLIAKMIAKIKQAPDKsea---vaaFSQFRRATVNEEADITHKLLGEEFQGDIDmLLPFLNEALKEEtvshWFTSEGIR 234 Saccoglossus ko...
KFM65223     152 IMLIARMIATVKQAKDKaga---ahlFSQFCHKTRSKNGDIAHRLLGKQFQAEVEhLRQLMIEGLQDEdllqWFTIEGFR 228 Stegodyphus mim...
ESN95592     147 IMLAARLIATVKQKSDPlerkefvdkLSTFCRSLTNDENNIIHKLLGNQFQHQIEvLREILKESFYEEsikeWFEPDGFK 226 Helobdella robusta
KJE96973     228 IMLLARIIAMLRQGLDKnskd-aftaFQQFYRCYADAEGHFIHKFLDKKYDKQLAfIQELFKTALYDDripeLFTTHGFR 306 Capsaspora owcz...
EDV22754     161 IMLIAKMIAMIEQADDPmdv---lklFSQFSRVTANNEAHVAHKLFGKQFVEQIEiLRLELINTLPSSkiteWYTPGGFR 237 Trichoplax adha...

Feature 1                            #   #   #          #######                        #####     
Q6GMV2       244 SLFALVGtNGQGIGTSSLSQWVHACDTLE-LKPQDREQLDAFIDQLYk-DIEAATGEFLNCEGSGLFvLQSCCNHSCvPN 321 human
XP_013390066 224 SLFALIGtNGQGVGTSSLSVWVHNCDALE-LSDEERQTLDAFIDQLYv-DIEKESGTFLNCEGSGLYtFQSACNHSCqPN 301 Lingula anatina
OWF55049     230 SLFALVGmNGQGIGSSAISVWVKNCEKLS-LSDEEKQKLDGFIDQMYe-DLDRVSGTFLDCEGSGLYrLQSTCNHSClPN 307 Yesso scallop
EDO34962     232 SLFALVGtNGQGIGTSSLSLYVHNIDSYPaLSDDERQAIDIFLNQLYe-EMERVSGQFLNCEGAGLYaLQSSCNHSCaPN 310 starlet sea ane...
XP_011665824 228 SLFALIGmNGQGVGSSSLSVYVHNCDELD-LEAEERQNLDQFIDQLYv-EMEKESGAFLNCEGSALYkLQSCCNHSCvPN 305 purple sea urchin
XP_002735533 235 SLFALIGtNGQGVGTSSLSVYVHNCDALD-LNTDDRQRLDLFIDQLYv-DIEKESGSFLNCEGSALYsLQSCCNHSCvPN 312 Saccoglossus ko...
KFM65223     229 SLIALVGtNGQGIGTSAFGVWVKNCDSLD-LPYEEKEKLNTFIHELYe-SIEKETGSFLNNEGSGLYpLQSACNHSClPN 306 Stegodyphus mim...
ESN95592     227 SLLALIGtNGQGIGTSSFSVWATNCEKKI-ADENLHKELSDLIDELYddLNNIAGPEFLDCEGSGLYlLQSACNHSCvPN 305 Helobdella robusta
KJE96973     307 SLLALVGmNGQGVGTTALDMYLVAVERLN-LSESDAKTRDQFVEKLLd-DIDEHSGEFDACEGSALYcLQSCCNHNCqPN 384 Capsaspora owcz...
EDV22754     238 SLLAMIGtNGQGIASSSFSQYARNVDAAK-FEKQEEDYINSFLDQLYa-DMNEESGDFLDCEGSGLYlLQSCCNHDCsPN 315 Trichoplax adha...

Feature 1          #             #          #######                  #####      
Q6GMV2       322 AETSFPENNfLLHVTALEDIKpGEEICISYLDCCQrersrHSRHKILRENYLFVCSCPKCLAE 384 human
XP_013390066 302 AEVTFPHNNfTLQMVAVQDIKaGEEICISYLDECDrersrHSRQKALRENYLFNCNCSLCQSQ 364 Lingula anatina
OWF55049     308 AEITFPHNNhRLALVATEDIQiGEEICICYLSECDigrsrHSRQKLLRENYLFHCGCARCLAE 370 Yesso scallop
EDO34962     311 AEVTFPKNNsTLVLKALHPIKnGEEICISYLEECQrersrHSRLKYLRENYIFDCTCTKCELQ 373 starlet sea anemone
XP_011665824 306 AEISFLHNNsTLSLVALTDITeGQEVLISYLDECCkersrHSRQKELRENYLFMCDCPKCRLQ 368 purple sea urchin
XP_002735533 313 AEVTFPDNDaAVSVMALQDIQeNEEICISYLGECDigrsrHSRQKILRENYLFNCNCMKCQSQ 375 Saccoglossus kowalevskii
KFM65223     307 AEATFPYNNfTLVMEAIKEIQpGEEIIVCYLDECNrnrsrHSRIKLLRENYLFTCTCPKCESQ 369 Stegodyphus mimosarum
ESN95592     306 AQVTFPHNNhILSLKAVKDIEpDQEIFISYLDECDrtrsrHSRHRLLRENYLFICNCPLCVSQ 368 Helobdella robusta
KJE96973     385 AVPTFTENNaTLHMRAERDISaGDEICISYLTPEQrhmrrSRRMATLRENYLFMCACAKCEVQ 447 Capsaspora owczarzaki ATCC 30864
EDV22754     316 VEINFLDNNaTLTVKAIRNISeGQELCISYIDSDIkn--wKKRQAILMENYLFECTCNRCMVE 376 Trichoplax adhaerens

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