Conserved Protein Domain Family
PTS_EIIC_2

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pfam13303: PTS_EIIC_2 
Phosphotransferase system, EIIC
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.
Statistics
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PSSM-Id: 433101
Aligned: 32 rows
Threshold Bit Score: 181.625
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ripcm:ACL_0491      27 SKTLNGMTFGIFGTIVVGAIIQTLGIITGID----------V--------------------------LNLRVAPVLTSL 70 
Q6LQ05              28 SAAMSGLADAAIATFLVEAIHKYVMGNLLGI----------G--------------------------YLAEFGNLVGGM 71  Photobact...
Q839R1              28 kKSLSALSGAACATFLPEAFLRYAVGGVFHL----------D--------------------------YVSQIGETMGSL 71  Enterococ...
Q2G165               1 MRAMGALANAAIATFLVEAFNKYVGGEVFGI----------K--------------------------FLEELGDAAGGL 44  Staphyloc...
Q8XP04              28 MKAMGALAGAACASFLVEAFHSSFFGNVLNI----------E--------------------------FLKKVGDANGSL 71  Clostridi...
wucgs:EUBELI_20512  32 IDALGAMAQGLFCSLLIGTILNTLGTQLHIGfltntvatvsG--------------------------VNYTVGGLASAM 85 
OLA07039            31 IDAMGAMALGLFASLLIGTIIKTLAENVGTTgl-------mAalasvtdtgelaakvaglstwnhfcwILWQIGNYATMV 103
Q5WEA3              19 IKAMGQMTFGLFATLIIGLIIKTAGEQFGI-----------A--------------------------AFLEIGELAMDL 61  Bacillus ...
CCY50188            18 iVAMNGMALGLFSTLIIGLIINQIGQAIPGSl--------gS--------------------------FLVSISPVAMAL 63 
CDC44356             1 ------MACGIFATLIMGMFLRQIANLFPSDf--------nS--------------------------TLIHLSGIATGL 40 
ripcm:ACL_0491      71 LGMGIGLSIGLSLKVDGLKLIMLSVAGGIGTLVKIDf------SMPGWFdpVKVSNNPITAYFVVIGAYFAIQAIF-RKK 143
Q6LQ05              72 GGVAAATLVMLRVGVQPVFAMVTGLA-------------------------MIHLG-ILEGFIVGYLFSFIAPLFKkYLA 125 Photobact...
Q839R1              72 GGLAAGALVPLAFGISPVFSIILGLS-------------------------LIKVS-LLPAFITAYLLSFVVEQMQkRIP 125 Enterococ...
Q2G165              45 GGVAAAGLTALAIGVSPVYALVIAAA-------------------------CGGM-DLLPGFFAGYMIGYVMKYTEkYVP 98  Staphyloc...
Q8XP04              72 GGVAAAILVPLALGVSPVYSVLIGLS-------------------------CSGLG-ILPGFIAGYLMSFVVKFLEeKLP 125 Clostridi...
wucgs:EUBELI_20512  86 SGPAMAVAIGYALKCPPLVLFSLITVGFASNA-------------------LGGAGGPLAVYFVAIIAAEAGKMIS--KE 144
OLA07039           104 TGVAMAAAIGYALDAPPLVLFSLCAVGQATNT-------------------LGGSGGPLAVLFVAIIACEVGKLVS--KE 162
Q5WEA3              62 YGAAIGAAVALALGAPSFVVLATIVCGTAGA----------------------VYGGPAGSFLAAVVAAETGKLVF--GS 117 Bacillus ...
CCY50188            64 TGPVIGIGIATSLESPKLVTLSSGVVGFIGAFGAVFangkiinSFGQLI--IKGSGDPLGAFIAVVIAAEVGRLVS--GK 139
CDC44356            41 TGIGIGVGVACQLQEAPLVILCAGIAGMLGGD-------------------AAGPSAFLCSFLAAFTAIELSRLFV--KK 99 
ripcm:ACL_0491     144 TAYDLFFIPIVGILSAVLVTYLISWPIDRFMEMIYSTIKFFMQLEPFVTSAFVALIFGILLTLPfISSAGVAIAVFSVPf 223
Q6LQ05             126 EGIDVILGVLILAPLARLVGFFISPALDLLMGTLANMITEATSLSPLIMGFLLGGLIKMVCTSP-LSSMALTAMLGLTG- 203 Photobact...
Q839R1             126 EGIDLLVVILVIPVAASLVAGFIQPVVLGVLEVIGGTILSAVDGNPYVMGAILGAIIPIVGMTP-LSSMVLTALIGLTG- 203 Enterococ...
Q2G165              99 DGVDLIGSIVILAPLARLIAVLLTPVVNSTLIRIGDIIQSSTNTNPIIMGIILGGIITVVGTAP-LSSMALTALLGLTG- 176 Staphyloc...
Q8XP04             126 SGLDLIVIIVVATPLTRIIGDFTAPVVDSTLLKIGQVLIASANSNPITMGIILGGIITVVATAP-LSSMALTAMLGLTG- 203 Clostridi...
wucgs:EUBELI_20512 145 TKIDILVTPLVTIGVGTGVAALIAPALGKAAMKIGELIMLATNLQPFLMGIAVSVLVGIALTLP-ISSAAICAAFGLTG- 222
OLA07039           163 TKIDILVTPAVTIIVGVGCAMVLAPIFKTICDSLGTFIGWATNLQPFFMGIIISVVVGVVLTLP-ISSAAICAAVGISGg 241
Q5WEA3             118 TKVDILVTPIVTIMSGFAVAWLLGPAISFVMESISGAIAWATDQQPLMMSIVVAILMGWALTAP-ISSAAIGLMLGLEG- 195 Bacillus ...
CCY50188           140 TKIDIIVTPLVTIITGSLIAVLLGPRLLYAMKSIGSFIQMATNLAPFTMGLVISVVMGMLLTLP-ISSAAISIILGLSG- 217
CDC44356           100 TRFDLFLCPLTGFLCGELINLLLETPLSYFIQEFGNCVNWGAQQQPLLMGIIVAVLMSIAVIFP-IGTAALGVIAGLSG- 177
ripcm:ACL_0491     224 gvgnala------ipdpiaiAAMCAAAIGCSTQMV--GFSVQTLRKNNLGSIFTVGLASSMFQFKNVMRKPI-VWAPTLI 294
Q6LQ05             204 --------------------LPMGIAAMACVGGSFtnGYVFHTLKLGKSCNTVSVML-EPLTQAHIVTRNPVpIFMSNFI 262 Photobact...
Q839R1             204 --------------------VPMAVGALTCYGSSIvnAALFKKLKLGTASTPLAVAI-EPLTQVDIISSNPIpIYATNLF 262 Enterococ...
Q2G165             177 --------------------VPMAIGAMAAFSSAFmnGTLFHRLKLGDRKSTIAVSI-EPLSQADIVSANPIpIYITNFF 235 Staphyloc...
Q8XP04             204 --------------------APMAIGALSVFGSSFlnFVLFQKMKFGSKKDTISVAI-EPLTQADIITANPIpIYVTNFI 262 Clostridi...
wucgs:EUBELI_20512 223 --------------------LAGGAAVAGCCAQMV--GFAVMSFKENRWGGLVSQGIGTSMLQMGNIIKNPR-IWIAPIV 279
OLA07039           242 avlagvldgsismdvwnglaLAGGAATVGCCCNML--GFAVISYPDNGVGGLVAQGLGTSMLQVPNLMRKPI-LWIPPVL 318
Q5WEA3             196 --------------------AVACAAAIGCAGQMV--GFAVASFRENRFGGLLALGIGTSMLQMPNILKNPL-ILIPPTI 252 Bacillus ...
CCY50188           218 --------------------ISAGASAVGCCSQMI--GFAVITYHVNGLNGALANGLGTSMLQVPNILKKPV-IWIPPIV 274
CDC44356           178 --------------------PAAGAATIGCCCSMV--GMAVASYRENGFSGLLSIGTGTPLLLLPNILKNPF-LLLPPIL 234
ripcm:ACL_0491     295 ASFILAPLSYFIfdgyqwfiNLIpvGHQFSAvwaGMGTSGLVGILQPL-----------TITNFSLdGWLFVSSMILFPL 363
Q6LQ05             263 GGAFAGTIAAYF--------GII--NDAPGS---AAPIPGLLASIAFN--------------PPST-LFMAASAAAVAGL 314 Photobact...
Q839R1             263 SGMVSGIVVTFF--------GLK--VPVTGM---ATPWAGLLVTLGNN--------------AIQT-TLLAVAIITVVSL 314 Enterococ...
Q2G165             236 GGAIAGLIIAMS--------GLI--NDATGT---ATPIAGFLVMFGFN--------------HPTT-IVIYGVVMAIVGA 287 Staphyloc...
Q8XP04             263 GGALCGIIIVLM--------GLT--NMSPGT---ATPIAGFAVMFAYN--------------PAFK-VLIASLACVVVSA 314 Clostridi...
wucgs:EUBELI_20512 280 TSAITGPMATCLf-------KLQmnGTPVSS---GMGTCGLVGQIGVYsgwiadiangtKAAITGFdWAGMILISFILPA 349
OLA07039           319 TSAILGPVATCIf-------QLRnnGAAISS---GMGTAGLVGPIGIItgwsn--mpegYAVGAFD-WLGMILVCFVLPV 385
Q5WEA3             253 AGAVSAPIGTIWf-------GLI--NNAAGS---GMGTSGLVGPIMTFte---------mGYSGSL-FIQVILCYVIIPA 310 Bacillus ...
CCY50188           275 SSAILGPISSVVl-------KMI--NNPAGA---GMGTAGLVGPLMAWqsm------apNVSGAIL-LMEILAMHFVLPA 335
CDC44356           235 SSAILGPLGVLLg-------KMQ--NSPNGS---GLGTMGLMGQTTTWet-------mtAGEAPQMvFLKILLFHFILPG 295
ripcm:ACL_0491     364 VLVFWLDVVF-----IKLNWYTEN 382
Q6LQ05             315 LGGVIGVKIY-----RTFLQERVP 333 Photobacterium profundum
Q839R1             315 MFGFLGALVF-----KRYRIEavd 333 Enterococcus faecalis
Q2G165             288 LAGYLGSIVF-----KKYPIVTKQ 306 Staphylococcus aureus subsp. aureus NCTC 8325
Q8XP04             315 GSGYLGYLLFknykiHTVDEIRGN 338 Clostridium perfringens
wucgs:EUBELI_20512 350 VICPLI-NMLl----KKIGWVKDG 368
OLA07039           386 LLSWAIGKFM-----RKKGWIKEG 404
Q5WEA3             311 VCAFIVSEWM-----RRKGWIKWN 329 Bacillus clausii KSM-K16
CCY50188           336 IISLAVFKFM-----VSKKIVSPE 354
CDC44356           296 VLTLFIANGM-----RKLNLIKSQ 314
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