Conserved Protein Domain Family
DUF4780

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pfam16012: DUF4780 
Domain of unknown function (DUF4780)
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 132 and 144 amino acids in length. There is a single completely conserved residue W that may be functionally important.
Statistics
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PSSM-Id: 464972
Aligned: 37 rows
Threshold Bit Score: 131.336
Created: 26-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012548400         553 PELKVAVTLEGYPTDKLEAPHMKLMKRAFKDfvhkDAKMKRFDclMQPHFHDVYLANGALIYICNCIESKDYLLEVLPKL 632 
XP_002002305         210 lrvmnqarlkSHLDE-----RFLQMSDSIKQ----QLASQKYV---------CIT-----TNICSNSSEYNYF------- 259 
XP_016036974          85 ECVRIGLAAES-AGTSLTSEQMTMIKEAIID------VTVEQSgsQKPQFEGCVARRGWLLVTCSNSSTSEWFKQNFCHI 157 
XP_001999397         269 PNLNVAILPGDYPSELWTTEQLEAVKKSICD----LVQRQGEGc-VKPSFAGCIFRNGWLSVHGNDAASVNWLMAMDTRL 343 
EDX16273              67 VAIKVQVVPEGYRKVVLSSENLSQLEDALLE----EIVLSGWD--SPIKFGGIHFRVGHLIVDCRNATTAEWLQLSVPSL 140 
EDW04833             133 KKVKVAVLPVSFPRVMLSHGDLSVLEEAIID----EVIASDGD--VAVSFVGIHFRVGFLVIKCSDETSADWLRIATSRL 206 
WGS:AANI:GJ17224-PA  459 NEMTVSLMPVGYPNEKLSHQEKLDLEEAILQ----EVVAAGATaaAPLRFSSIHFKAGFLKVDCSNQATADWLVHTAEHI 534 
XP_001987554         362 NELTVCLVPVGYPNESLTHQDKLDLQEAILH----EVVMAGPQtaAPLRFSNISFKPGFLKVNCANQVAADWLLQTGSRL 437 
XP_011143405         138 DLREIAVVPVDYPDKKLDANEVALIRRLIKL----RILGLANGt-KTPTFKAAWEWEGTLIFGCNDEHTRDWLKSFMSEI 212 
EFN70505             181 GFVTLALTLEGYPDKRLGVGECSIIRKLIRE----RILELSEDt-KAPTFSGSWERDGALVFTCVDEQSGDWLKNLSSDL 255 
XP_012548400         633 ILATGLRLSVRDIK--DLVRYTRVVFRLPKEIaHKASEEVLNALKKSYSGLKIECWKYYS----SVIGKQRREFGLDPES 706 
XP_002002305         260 -VYSCHWLDekfqrhsaalacrrfsgdyaqvletirkinnvyafnnlkivgsitnndrnyskafqefgidlkkeinnqdh 338 
XP_016036974         158 QSKVTTKLKLMDES--ELPRRNVVLGYFPDSL-TTSSQKVLEIIQAQNP-VSTAEWRVMNr--lTHGELLHLSMAVDNES 231 
XP_001999397         344 RPWAGASLKVLPES--EVPCNRVFVGLFPALY-STPVKYTLRLIDAHNEGLAVHEWRVLHr--lQSGPTMKLAVSIDAHS 418 
EDX16273             141 SKWSGISLEVKMCD--DLPSSHNITIFCPRTG-DKTTKWIMELIKKQND-LDTENSRLISr--kNEGGGSLLSLGIDDNS 214 
EDW04833             207 QSWKGVPLECKVGD--DIPSPHCITLFCPRSA-ARSTESLLVLLRNQNR-IETDTWKVISr--rNEGGGALLVIGIDELS 280 
WGS:AANI:GJ17224-PA  535 YSYKGRPVVPKLGD--PKSKFFYITIFLPRSE-GKSEEFLLGLIRSQNK-YNTDLWKVVSr--kAQAGGTLLVLSIDKTS 608 
XP_001987554         438 YSYNGRPVEAKLGSvkAPGQKIFISIFLPCSA-GKSDEFLLSLLKSQNQ-YNTNLWKLASr--kDHGGGAVLVLGIDKES 513 
XP_011143405         213 IVKEKVPVRALPAD--ELFGRHHVVVHVEDP--EMSVKESLEFLHRQNKELLVNEWVIACrk-sRDAVRSHFSALVSGRS 287 
EFN70505             256 -KLGENSLCVLSVD--ELPKRHRVMVHVEES--DVSAEEALKLLGKQNTGLATNDWIVIKesesRDATNTHFACLIRDPS 330 
XP_012548400         707 LLIIKSPEFKPTYEGHILEFR 727 
XP_002002305         339 invddlkelicealpnrmeca 359 
XP_016036974         232 HKKLIELNGTISFRFGRVKLC 252 
XP_001999397         419 AEVLKQMDYQLNYGFSRVHFR 439 
EDX16273             215 CAKIISGDHKLSFSLGDISvc 235 
EDW04833             281 KNVIVEKGHQVFFRYGTIPVs 301 
WGS:AANI:GJ17224-PA  609 ATDIAANDYAIFYRYGTVPVR 629 
XP_001987554         514 AADIAANDHSIFYRYGTVPVR 534 
XP_011143405         288 LKVLEGLSFKPFCGLSQVTVK 308 
EFN70505             331 LETLKACNFKPFCGLGQATVR 351 
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