Conserved Protein Domain Family
GT29_ST8SIA5
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cd23990: GT29_ST8SIA5 
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467718
Aligned: 6 rows
Threshold Bit Score: 542.506
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              ###       
O15466        98 SEANQFKSTLSRCCNAPAFLfttqkntpLGTKLKYEVdtsgIYHINqeifRMFPKDMPYYrsqfKKCAVVGNGGILknSR 177 human
Q6KC02        67 EETDNFKMSLSRCCNAPSFLfttkrntpSGTKLRYEVdtsgILHISpeifKMFPDDMPFSksqfKKCAVIGNGGIIknSK 146 zebrafish
XP_014354418  95 TEAKAFKSYLSRCCNAPSFLfttqkntpLGTKLKYEVdssgTYNINseifKMFPKDMPYSrtqfKKCAVIGNGGILksSG 174 coelacanth
OCT98888      54 MEANVFKSSLLRCCNAPSFLfttqkntpLGSKLRYEVdtsgIFQINseifNIFPKDMPYYrsqfKKCAVVGNGGILkdSK 133 African clawed ...
NP_001279920  95 NKTEANTARLTNCCNAIQNFtvtqvntaLGANLTYDAqpkkQITITedifNLLPQEMPYSrsqfKKCAVVGNGGILkkSE 174 elephant shark
NP_001001747  98 TEANILKSTLSRCCNAPAFLfttqkntpLGTKLKYEVdtsgIFHINqeifKMFPKDMPYHrsqfKKCAVVGNGGILknSR 177 chicken

Feature 1                     ##                     #                                           
O15466       178 CGREINSaDFVFRCNlPPISEkytmDVGvKTDVVTVNPSIIterfhklekWRRPFYRVLQvyenASVLLPAFyntRNTDV 257 human
Q6KC02       147 CGREIDAsDFVFRCNiPPVSDlysqDVGsKTDLVTINPSIIterfqklekWRKPFYEVLQnyenSSVVLPAFyntRNTDV 226 zebrafish
XP_014354418 175 CGREIDSmDFVFRCNlPPISEkyvlDVGfKTDIVTINPSIIadrfhklekWRRPFYTALQayenASVVLPAFyntRNTDV 254 coelacanth
OCT98888     134 CGKDIDNtDFVFRCNlPPITQkyveDVGmKTDVVTINPSIIterfnklekWRRPFYEVVQgyenASLLLPAFyntRNTDV 213 African clawed ...
NP_001279920 175 CGKEINSaDFVFSCNlPPLSNeyarDVGhRTQLVTANPSIIkkrfqkldkWRRPFVELLQvyenTSVVMPAFyntRNTDV 254 elephant shark
NP_001001747 178 CGREIDSaDFVFRCNlPPISEkyltDVGvKTDVVTVNPSIIterfhklekWRKPFYDVLQvyenASVLLPAFyntRNTDV 257 chicken

Feature 1                                                  ###                 ##            ### 
O15466       258 SIRVKYVLDdfespQAVYYFhpQYLVNVSRYWlslgvrakriSTGLILVTAALElCEEVHLFGFWAFpmnpsglyITHHY 337 human
Q6KC02       227 SFRVKYMLDdfessRGVFFFhpQYLLNVQRFWavqgvrakrlSSGLMLVTAAMElCEEVHLYGFWAFpmnpsgifITHHY 306 zebrafish
XP_014354418 255 SFRVKYVLDdfesqQSVYFFhpQYLLNASRFWsnqgvrakrlSSGLMLVTAALElCHEVHLYGFWAFpmnpsgifITHHY 334 coelacanth
OCT98888     214 SIRVKYVLDdfesqQAVYYFhpQYLISVSHFWlmqgvhakriSSGLILVTAALElCEEVHLYGFWGFpmdpsgnfITHHY 293 African clawed ...
NP_001279920 255 SLRVRYALDdfsapQDLFYFhpRYLENVARFWgrqgvrakrpSSGLMLVTAAMElCQEVHLYGFWGFpmdpsgihITHHY 334 elephant shark
NP_001001747 258 SIRVKYVLDdfesqQAVYYFhpQYLINVSRYWlgqgvrakriSTGLILVTAALElCEEVHLFGFWAFpmnpsgifITHHY 337 chicken

Feature 1                  #                      
O15466       338 YDNVkprpgfHAMPSEIFNFLHLHsrGILRVHT 370 human
Q6KC02       307 YDNVkprpgfHAMPYEIFNFMHMHarGIVHVHT 339 zebrafish
XP_014354418 335 YDNVkprpgfHAMPSEIFKFLHMHskGVLRVHT 367 coelacanth
OCT98888     294 YDNVkprpgfHAMPSEIFNFIHMHskGILRVHT 326 African clawed frog
NP_001279920 335 YDNVkprpgfHSMPNEIFTFLHMHsrGVLQVHT 367 elephant shark
NP_001001747 338 YDNVkprpgfHAMPSEIFNFLHMHskGILRVHT 370 chicken

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