3VPY


Conserved Protein Domain Family
FHA_DDL-like
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cd22719: FHA_DDL-like 
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forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins
DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438771
Aligned: 8 rows
Threshold Bit Score: 237.002
Created: 7-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
  • Comment:based on structures of other FHA domains with bound phosphopeptide
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 ###                 ## #               
3VPY_A         2 LLFNEPPEARKPSERWRLYVFKDGEplnEPLCLHRqSCYLFGRERRi----aDIPTDHPSCSKQHAVIQYREXEKEKPd- 76  thale cress
Q8W4D8       181 LLFNEPPEARKPSERWRLYVFKDGEplnEPLCLHRqSCYLFGRERRi----aDIPTDHPSCSKQHAVIQYREMEKEKPd- 255 thale cress
PNW78796     295 LKHVPPAEARKPDKRWRLYIFKNDQlqdEPYHIHRmDHYLFGRDLTv----aDIVTAHPSCSKQHAVLQFRLTEKAGGag 370 Chlamydomonas r...
PSC74318     240 LLHQEPPEARKPTARWRLYVFKGEQqleEPLHIHRmSAYLFGRERRi----aDIPTDHPSCSKQHAVLQYRLTEKEGAd- 314 Micractinium co...
XP_024403755 218 LAFTEPPEARKPSMRWRLYVFKDGEpmnEPLYIHRqTCYLFGRERKv----aDVPTDHPSCSKQHAVIQYRLTEIEGPd- 292 Physcomitrella ...
XP_024544443 185 LQFTEPPEARQPSVRWRLYVFKDGApleDPLFIHRqSCYLFGRERKv----aDIPIDHPSCSKQHAVIQYRLIEKEVD-- 258 Selaginella moe...
XP_005824788  57 LKFVEPMEARMPDKKWRLYEFKGDEq-lRILHLHRcSCYIFGRDRSlehfpgFVATDHPSCSKQHAVIQFRQHEKDDGv- 134 Guillardia thet...
XP_003057334 160 LVYVEPPEKTKPSLKWRLYVFKNGEltgEPLHIHRqSYYLFGRERKv----vDVPTDHPSCSKQHAVIQYRERTKWDDd- 234 Micromonas pusi...

Feature 1                               # ##                                    
3VPY_A        77 --------GXXGKQVKPYIXDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHE 131 thale cress
Q8W4D8       256 --------GMMGKQVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHE 310 thale cress
PNW78796     371 gfdeyglaVGPAAAVRPYLLDLGSINGTFLNGEKVEPLRYYELLEKDVVRFGQSSREYVLLHD 433 Chlamydomonas reinhardtii
PSC74318     315 --------GMMKAAVRPYMMDLGSTNGTFINGDRLEAEQYYELLEKDVIKFGNSSREYVLLKE 369 Micractinium conductrix
XP_024403755 293 --------GMMESKVRPYIMDLGSTNGTHLNNTRIESRRYYELREKDTLKFGNSSREYVLLHE 347 Physcomitrella patens
XP_024544443 259 --------GLMSKKIRPYVMDLGSTNKTFLNGEAVEPQRYYELFEKDTLKFGNSSREYVLLHE 313 Selaginella moellendorffii
XP_005824788 135 --------GGVILSVRPYLMDLKTTNGTQLNGERIDDMRYYELKERDNIKFGNSSRDYVLLHE 189 Guillardia theta CCMP2712
XP_003057334 235 -------eGADVKVAVPYIMDLNSTNGTHLNGDRIEPQRYYELLEKDTIKFGMSTREYVLLNE 290 Micromonas pusilla CCMP1545

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