Conserved Protein Domain Family
GET2

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pfam08690: GET2 
GET complex subunit GET2
This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.
Statistics
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PSSM-Id: 400847
Aligned: 31 rows
Threshold Bit Score: 178.75
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011274764   3 SEAEKRQKLRERRAAKIKNG--ASRLGKITGDYSEAQKDAetirTNPLSspet-----------------ksptPEPSIG 63 
EHK49016      16 rAAEQARLRKERREAKIKAGg-SARLERITGAGGRVTGDSgt-------------------------------tTPSGPD 63 
XP_013958705  17 rAAEQARLRKERREAKIKAGg-SARLERITGVGGRVTGDSqp-------------------------------tAPSAPA 64 
Q2GVT9        15 raAEQARQRKARREAKIKAGa-ENRLNRITGLGGGVPRDPap-------------------------------aPAASKT 62  Chaetomium glob...
CCE41938      11 SEEEKRRILRERRQAKMAKGkaSDRLNNILTQGASVKTSTv---TSVLDkpe--------------------paAATALP 67 
A5DSM4        10 TEAEKRKLLRERRLAKMAQGkaSDRLNTILSQGSSVKSVSppavTSVLEnkatkstdtatvtdsstnatsvspsAAKATP 89  Lodderomyces el...
C5MBE2        12 SAEEKRRLLRERRQAKMAKGqaTDRLNNILSQGSSVKTTGv---KSVLDepq--------------------ptAT---- 64  Candida tropica...
EMG49598      12 SAAEKKRLLRERRQAKMAKGqaTDRLNNILSQGSSVKASGv---KSVLDeek--------------------psIP---- 64 
C4YCC3         5 SAEEKRKLLRERRQAKMAQGkaTDRLNNILSQGSSVKSSNv---TSVLDkpe--------------------kaTTTVMD 61  Clavispora lusi...
C4R3U0         5 TEAEKRQLLREKRKAKLSQGggLDRLKKITGENNSKLSTDvp-------------------------------tKEPTAD 53  Komagataella ph...
XP_011274764  64 KETPISKSSGASkrisqsfDHE-DP--EVEDisnfepikesskessRANQPSDQLDEAQ-----QFEqMLQQMLGSvphQ 135
EHK49016      64 ASSTAPAAT----------EHH-DP--AEVDisehffapkktsrkpIDGVFSP--SPEPslseaQLRqMMLGLDRP---E 125
XP_013958705  65 TLSKASTSD----------EHAtDP--AEVDisehffvpkktsrkpLDGVFSP--SPEPslseaQLRqMMLGLDRS---D 127
Q2GVT9        63 ATATTTPSAPVSta---aaQHA-DP--DEVDisehfyqp---------qttarvpPPDSnlsdtQLRqMMLGFDQP---G 124 Chaetomium glob...
CCE41938      68 TALTHDD--------------D-DP--DIQDisti---------tasdPPLGEK-DPQV-----EMNeMFKSIFQQ---Q 112
A5DSM4        90 TSTGVSSAISDF---------D-DP--EIQDisdvavnnsgvlalgNLSGLDSN-NPSQp----NLDeMFQKIMQQ---Q 149 Lodderomyces el...
C5MBE2        65 ------SSAIHD---------E-DP--DIQDiseias------pppptPPIGEG-SPE------NIDdIFQKMLQQ---Q 110 Candida tropica...
EMG49598      65 ---------EHD---------D-DP--DIQDiaeiai------ppaptPPIGEE-PPQ------DIDsIFHKMLNQ---H 107
C4YCC3        62 LPSRETQSPTPL--------HD-DP--EVPDitsl----------------lkekENEAp----DMEaMLQQILGG---S 107 Clavispora lusi...
C4R3U0        54 ATTTATELPTQGlet-rinAHD-DPvsEIPD------------------PLNEGFDGKEp----DLDqLIASMF-----N 104 Komagataella ph...
XP_011274764 136 HQGDSNNSTDAPQGTPdfD-IFSKLLSGDANGQGNpfgslgsmgalqqtqaqknqsqgydpahpDVNLEQIEYQKQLSEY 214
EHK49016     126 QAGP-PGGNPAGMNLPpgM-EDDPIMKMMSQMMSSgsipgfgg--------------adgapnpFGNMQMPQQQAPVELP 189
XP_013958705 128 QPSPVPGAT--GPALPpgM-EDDPIMKMMSQMMSSgsipgfgg--------------adgasnpFANMNLPQQQAAVQLP 190
Q2GVT9       125 TATPPMPGMPGMPSPPpgM-EDDPMMRMMMQMLGGggnnpfgggm---------pgmpfppsttPGSGAQPFPPQPQQSA 194 Chaetomium glob...
CCE41938     113 QQSSQDDAN-----------PMAEIFKMLGDPNSVddq-----------------------niqSPNSAQSQYEQQLNQY 158
A5DSM4       150 SQHNCDNDNNGEN-----N-PMAEMLKMFNSMGGGdnngglggfdsm------fsgspnspppeSISPEMMKYQADLAKY 217 Lodderomyces el...
C5MBE2       111 VQGKDGKVDPN-------D-PIVQIMNMFKDGSGAdgpqegd----------------vnanefSNDPVENKYQQDLQAY 166 Candida tropica...
EMG49598     108 TQGKISDDPN--------D-PLNQIMKMFNEGGAGanlpnd------------------stqafSDDPVEAKYQQDLQAY 160
C4YCC3       108 GAHTGPGNDGGAN-------FLQEMMKAMAEDPSG-----------------------------GSTAEESSYQSQLSQY 151 Clavispora lusi...
C4R3U0       105 KSAGHENPNSEEQGVPelMrRFSSILQGGDSGAAGlgaeagginpldllnslggsnigkaqeeyGSTPEEIEFNKKSIAY 184 Komagataella ph...
XP_011274764 215 NKIQNDKFKAKFMLFKFIISFg-LTIYFFgi--qgFYSSSV------------EIFRIHKLDS----GFSKIWLTLEILF 275
EHK49016     190 KSSSVTLWRVVHALVAIGMGLf-FILTTH------FTGSKIerer----malaHEQEVDDEMErrknLFFWTFATAEVLL 258
XP_013958705 191 KSSSVSFWRLIHALVALGLGLf-FVLTTN------FSGSKVerer----talaFEQEVDVEAErrknLFFWTFATAEVLL 259
Q2GVT9       195 TNRHATLWRLLHALIALALGLy-IAVYTP------FTGSKLsrdsaaaaaagsAEARADFGASps-qNYFWAFATAEALL 266 Chaetomium glob...
CCE41938     159 HMYQKQVWKFRFSVVRFLTIVt-FFFYHYcsi-psFTSSNH------------AYVRDLTEVYpl-sGFAQGFFTLEVAI 223
A5DSM4       218 HTYQEQLWQFRFLVVRILATIf-NFAYHFiti-psFTASNH------------AYVRDLSEVYpl-lGFMTIFTSIEVVI 282 Lodderomyces el...
C5MBE2       167 DTYQQKLWKSRFLVIRVVVTLf-NFFYHYlnv-psFHASNY------------SYVRDLAQDEfpvrNFFTWFAAFEVII 232 Candida tropica...
EMG49598     161 NTYQQKAWKFRFLVIRAMLTLf-NFFYHFvtl-psFQASNY------------TYVRDLSNDEdpvrNFFTWFATCEVVI 226
C4YCC3       152 HAYEQKQWKARFLVVRWIIHTl-NFVYHYiasgykLSASPY------------AFVRAQAVDShv-rTFFTAFLTVEVAV 217 Clavispora lusi...
C4R3U0       185 KKHQNEVLKAKILVVRLVLILslLFVYGRdfs-------------------lsLFTQTYAPNGs---SFMRVFLTLELIF 242 Komagataella ph...
XP_011274764 276 TSYYALHLNKIQDSHY----NYNSKILKILGYVPDMFLS--PYYKNKIRWFVKYQELIHLIIFDLSVIIFLFGILS 345
EHK49016     259 LSTRLFLDKKST--------NATGFIATAISYLPQP-------YRGYIEIGQRYIQIFTTVRTDILTCIFVLGVVS 319
XP_013958705 260 LSTRMFLDKRST--------NATGFVATAISYLPQP-------YRGYIEIGQRYFQIFSTVRTDILTCIFVLGVVS 320
Q2GVT9       267 LGTRHFVADRGRSRLQaaaaGGSGMLGMAVGFLPAG-------LRSKVELAMRYGEVLGSVRADVLVCVFVLGVAa 335 Chaetomium globosum...
CCE41938     224 IASYYFIL---TKNGLfhaaRQNNLVMKGVQ-IVSMFAPqvQQFAPILSRVLEYKELLGIFLVDLSIVVVLFGLLS 295
A5DSM4       283 IATYYLLF---TKLGLfhasNQKSFILKGIS-TLSMFVPqlLRYEPLVATFLGYKELLGIFVGDLSLVVVMFGLLS 354 Lodderomyces elongi...
C5MBE2       233 VLQYYTVF---HKLGLfhaaNQNSMIMKLMS-MGSMVLPqlNTYQPLVARFLGYYELFGIIFGDLSLVIVLFGLLS 304 Candida tropicalis ...
EMG49598     227 VATYYSVF---HSLGLfhaaNQNSIVLKLMS-MGSMVLPqlAAYQPLVARTFGYFELIGIIVGDLSLVIVLFGLLS 298
C4YCC3       218 ISAYFLVM----SQPKfkdfSRENLVSRILS-MASAVVPavGRYQPLVTRALVYWNGASIFVGDLMLMVFYFGITS 288 Clavispora lusitani...
C4R3U0       243 QTSLFFFI---SKNKNf---TDDSLISKLLN-IGGAFIP--ATYRNLLQTASKYQVLLSMFLFDLSIVVVVFAira 309 Komagataella phaffi...
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