Conserved Protein Domain Family
7tmA_OXER1

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cd15200: 7tmA_OXER1 
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.
Statistics
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PSSM-Id: 320328
Aligned: 5 rows
Threshold Bit Score: 399.529
Created: 4-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###########################                                                    
Q8TDS5        93 AFLAPILALEFVLGLVGNSLALFIFCIHTRpwtsNTVFLVSLVAADFLLISNLPLRVDYYLlhetWRFGaaaCKVNLFML 172 human
EMP29970      11 VTIASVLGVEIVIGLVGNGIALSIFCSYRNlwpsSTMYLFSLVIADFFLIINLPFRIHYYMknevWVFTetfCSVNLFML 90  green seaturtle
XP_007476953  14 AFLAPVLTLECIVGLVGNGFAFFIFCVHIRpwksNTIFLLCLVIADFLLIINLPFRIDYYVngqkWNFGpgaCKANLFMM 93  gray short-tail...
XP_006265225  13 KILVPVLGIEYVMGIIGNGIALIIFCFNRNfwksSTMYLLSLVVADFFLITSLPFRMHYYTrnevWTFSkrfCQVNLFML 92  American alligator
XP_004700112  76 AFMAPVLAIEFVLGLLGNGVALLIFCFRLRpwtsNTVLLVCLVVADFFLVANLPLRVDYYLceemWRFGataCQVNLFMI 155 small Madagasca...
Feature 1                                                                                        
Q8TDS5       173 STNRTASVVFLTAIALNRYLKVVQPHHVLSRAsvGAAARVAGGLWVGILLLNGHLLLstf----sgPSCLSYrvgt-kps 247 human
EMP29970      91 SMNRTASIVFLTAIAMDRYFKVVHPHHELSKIstSCAAKVAIALWIIVILVNSHVFTldhn-qsknSACQSYnphl-epq 168 green seaturtle
XP_007476953  94 STNRTASIIFLTAVALNRYLKVVWPHHTLSRAsaRSAAQVSVGLWVLILLMNMPLLLqdhqpvysnFSCLSFtins-tgs 172 gray short-tail...
XP_006265225  93 SMNRTASIVFLTVIAVDRYFKVVHPHHQLSKLsiPCAAKIAALIWILCILLNIHIFTlhvv--qdnTTCRGYdhpkadis 170 American alligator
XP_004700112 156 SANRTASVVFLSTVALNRYLKVVHPHRALSQAsvGTAAWVAAGLWGGILLLNCHLLLsss----agSTCLSYqlgt-nss 230 small Madagasca...
Feature 1                                                                                        
Q8TDS5       248 aSLRWHQALYLLEFFLPLALILFAIVSIGLTirnrglggqAGPQRAMRVLAMVVAVYTICFLPSIIFGMASmvafwls-a 326 human
EMP29970     169 aAATWHTILFFLEFFLPLGIIMFCIFNIILKlkqrklakrNKVQRSVKVLTVIVLVYTVCFLPTILIAAVGlvtlkvs-- 246 green seaturtle
XP_007476953 173 iPQRWHHILYVLEFFLPLGIILFSIFSIIITirrrkldkqAGTRRAVLVLGVIVTVYISCFLPSIVFAIASilaqrvs-n 251 gray short-tail...
XP_006265225 171 lVDHWHRMLIFIEFFISLGIIFFCIFRVLFKlkqkemargKRIQRTMKLLIIIVLVYSVCFSPVILFALAVlivwkvspq 250 American alligator
XP_004700112 231 aSDRWHELLFGLEFLLTLGLVLFAVASIRRTvqrrglggqAGPRRALRVLAVVVAVYAICFLPALVFGTATiaafelg-s 309 small Madagasca...
Feature 1                                                
Q8TDS5       327 crsldlCTQLFHGSLAFTYLNSVLDPVLYCFSSpnFLHQS 366 human
EMP29970     247 pehigtIDQLLRASFAFTYLNSALDPVLYCFSSqvFLNRC 286 green seaturtle
XP_007476953 252 cqtlnlCTELFHGALAFTYLNSTLDPMLYLFSSpsFLHQS 291 gray short-tailed opossum
XP_006265225 251 slsykvMNQLFHASFAFTYLNSALDPVLYCFSSvtLQNRF 290 American alligator
XP_004700112 310 crifdlCAQLFHGSLAFTYLNSALDPVLYCFSSpsFLRQI 349 small Madagascar hedgehog

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