Conserved Protein Domain Family
HMG-box_SoxG_SOX15
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cd22035: HMG-box_SoxG_SOX15 
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 15 (SOX15) and similar proteins
SOX-15, also called SOX-12, SOX-20, SOX-26, or SOX-27, is a crucial transcription factor involved in the regulation of embryonic development and in cell fate determination. It binds to the 5'-AACAAT-3' sequence. SOX-15 can be a tumor suppressor in multiple cancer types. SOX-5 is the only member of group G SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438844
Aligned: 4 rows
Threshold Bit Score: 159.861
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure evidence that Homo sapiens SOX-2 binds DNA
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # ## #####   #  ##      ######  ##  #  ##      #          #           ####
O60248        42 GTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPR 121 human
P43267        40 GGLPLEKVKRPMNAFMVWSSVQRRQMAQQNPKMHNSEISKRLGAQWKLLGDEEKRPFVEEAKRLRARHLRDYPDYKYRPR 119 house mouse
XP_028559641  35 PEDPLEKVKRPMNAFMVWSSAQRRKMAQEHPKMHNSEISKRLGAAWKLLPDAEKRPFVDEAKRLRALHMKDYPDYKYRPR 114 Common wall lizard
XP_029768920  10 GGDPPDKVKRPMNAFMVWSSGQRRRLAQEHPKMHNSEISKRLGAAWRRLPEAEKRPFVEEAKRLRARHMRDYPDYKYRPR 89  Three-toed box ...

Feature 1        ##  
O60248       122 RKAK 125 human
P43267       120 RKSK 123 house mouse
XP_028559641 115 RKGG 118 Common wall lizard
XP_029768920  90 RKGR 93  Three-toed box turtle

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