2EE7


Conserved Protein Domain Family
CH_2
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pfam06294: CH_2 
CH-like domain in sperm protein
Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.
Links
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Statistics
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PSSM-Id: 461871
Aligned: 144 rows
Threshold Bit Score: 60.5228
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2EE7_A        20 LYLWVDNIPLSRPKRNLSRDFSDGVLVAEVIKFYFPKMVEMHNYVPANSLQQKLSNWGHLnRKVLKRLNFSVPDDVMRKI 99 
9_pfamImport   1 SLKGLQLIPNH--LKTPSQDFSNGFLVAEIFSRFYPEDFPMHSYGNGTSLPTKQSNWSQI-EKGLMKLQLSLVKEAVDGT 77 
XP_023184085  15 VIKWLQDLELSFHPRNLRRDLSNGYLVAEIFSRYYPHDISVYSYHNGVSFSSKQKNWSRI-QKFLKKKNLELSKEVIYGS 93 
XP_002709370  55 VLRWLQGLDLSFSPKNIKRDFSNGFLIAEIFSMYYPWDLQLSSFENGTSLKVKLDNWAQL-EKFLARKKFKLPKELIHGT 133
Q5XLA5        12 VLRWLLSLGLSVSPRNYRRDFSNGYLVAEILSRRFPAHIQPDAYRNGCSLAAKLSNWSQL-RRFLAKQEFDIAQELIEGT 90  chicken
EEN67679      16 VLKWLQSLDLTYSVKNVRRDFSNGFLVAEIFSWYYPQSIQMHSYDNGTSLPTKLGNWSQL-ERVFVKHSLDIPKELIDGT 94 
EKC20206       8 VLKWIQSLDLTWQIKQAKWDLTNGYLIAEIFSWYFPQDIQMHSYNNGTSLDSKLKNWSLL-KLFIKRHKLEIPEELIEGT 86 
EDO30183       8 ILKWIQSLDLSHPVKNTKRDFSNGCLVAEIFSWYYPQEIQMHSYDNGASLATKMGNWSQL-QTFFQRQGFGISKEVIDGT 86 
XP_002116934   8 VIKWLQSLDLSVSVKYPKRDFANGFLVAEIFSWYFPQEIHMHSYYNAPSLPKKIGNWSQL-ERLFKKHGIDIPKVLIDGT 86 
XP_014321220  55 ILRWLQSLDLTFFPRNINrDFSNGFLVAEIFAIYYPWDLSLSSFKNGTSLRVKLDNWAQL-EKFLAKKKIRLPRELIYGT 133 little brown bat

2EE7_A       100 AQCAPGVVELVL 111
9_pfamImport  78 IHCKPGAAEALV 89 
XP_023184085  94 IHCEPGAAEQLV 105
XP_002709370 134 IHCKAGVPEILI 145
Q5XLA5        91 IHCKPGAAESLL 102 chicken
EEN67679      95 IHCKPGAAELLV 106
EKC20206      87 IHCKEGAAPALC 98 
EDO30183      87 IHCKPGAAALLV 98 
XP_002116934  87 MHSKPGAAILLV 98 
XP_014321220 134 IHCKAGVPEILV 145 little brown bat
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