Conserved Protein Domain Family
Chibby

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pfam14645: Chibby 
Chibby family
This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.
Statistics
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PSSM-Id: 464233
Aligned: 21 rows
Threshold Bit Score: 93.9132
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ETN60570       2 PIFQ-KKFAPKLIPPRTRRLNIGCPP-PSPADDVDD-----FRTITLNLV-DRQLCF--IDGVWMngltrpsgdVGSSGA 71 
XP_005995419  17 TKLN-YDFKPRRAPLRQPTSLSTLYI-MDYQSRMHElg-ldYGFPTLQLD-DQRYAF--QEGMWV---------SEPRSL 81 
XP_016847245  17 DHFS-RRFWPRRPVLRQATSLSTFYL-LDYKTRQAElg-mdYGPPTTELC-KTKFVF--KDGEWQ---------SENGPP 81 
XP_007671292  97 DHFSrRRFSPRRPPLRRISFMSTFYL-LDHRTRQAElg-lsYGPPRTRLS-RQTLIF--LEGRWV---------NDGEAA 162
XP_023374534  83 DHFS-RRFSPRRPPLRRISSMSTFYL-LDHRTRQAElg-lsYGAPRTRLS-DEAFVF--RGGRWV---------MEGQLA 147
EFX74391       2 PLFR-SKFQPKKCPARKTSTVSNLRRnMDALQLEREfs-iqIDKVKLDLGeNQQFEFnsENAKWV---------SISTAP 70 
OWR45304       2 PLFS-NKFSPKSIPVRRQDTSVIKNE-FGSDYASREls-idINPLKLKLG-DIELSF--EEGQWI---------PASGRA 66 
XP_001994431   2 PLFN-KKFESKPIPARINRCNIGFPV-INEDIED-------FRSISLSLG-NKELRF--ADGIWM----------HSARK 59 
EDS36001       2 PIFT-KKFAPKVAPPRTQRLNIGCPP--------HQedlddFRTIRLNLV-DKQLCF--VDGVWMsa-----lrGAGGGT 64 
EFN70831       2 PLFS-NKFSPKKTPTRKASVFLANKN-LSPKRIEKElg-peVGPIRLRLG-DQEAVF--EAGLWI---------PESGRV 66 
ETN60570      72 GGasvtgstaaaashaTTDDMLRMRRRLKTVEQENNLLQVKLDVLVDLLTENMIELNGIKNQ 133
XP_005995419  82 SGf-------------DKRVSRDSQETTRLLREENFFLKVKVELLLDMLTETTLKLLLLEDQ 130
XP_016847245  82 KMpllql----ysppdKESPNKALKKANKALLEENNYLKLQLELLMDMLTETTARLHSMEKR 139
XP_007671292 163 HSppl--------apaGGRSPARLAK-VQSLLEENNYLKLQQELLMDMLTEATARLQALEKK 215
XP_023374534 148 RSrpplp-----sptiAGWKAQVHRVKNQVLLEENNYLKLQQELLMDMLTETTARMHMLEKK 204
EFX74391      71 NA--------------KAKPSTLLQK----LEGENNYLKIQADLLLTMLTETALEAHLNSLD 114
OWR45304      67 GA--------------AHKENIRLKKELEQLEEENNMLRLKFEILLDMMTDKTVEAEQDMQR 114
XP_001994431  60 G---------------DVDDMLRLNKKFRALEEENNMCNLKIEVMLDLLAEQATEQATEQQA 106
EDS36001      65 SGagggpgggaaltstTIDDLLRMKRRIKALEQENNLYQVKLDVLLDLLTENVIELNTLKEQ 126
EFN70831      67 GG--------------TFKENEKLKKEVRRLEEENNLLKLKFDVLLDMLTQTTAEAHLQREE 114
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